Difference between revisions of "Ampulla of Vater"

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===Microscopic===
 
===Microscopic===
 
Features:
 
Features:
*Similar to adenocarcinoma in colon.
+
*Dependent on subtype.
 +
 
 +
Notes:
 +
*May lack desmoplastic stroma.<ref>{{Ref Sternberg5|1640}}</ref>
 +
 
 +
Main subtypes:<ref name=pmid15549428/>
 +
*Intestinal ampullary carcinoma.
 +
*Pancreatobiliary ampullary carcinoma.
 +
 
 +
===IHC===
 +
Features:<ref name=pmid15549428>{{Cite journal  | last1 = Fischer | first1 = HP. | last2 = Zhou | first2 = H. | title = Pathogenesis of carcinoma of the papilla of Vater. | journal = J Hepatobiliary Pancreat Surg | volume = 11 | issue = 5 | pages = 301-9 | month =  | year = 2004 | doi = 10.1007/s00534-004-0898-3 | PMID = 15549428 }}</ref>
 +
*CK7 +ve.
 +
*CK20 +ve.
 +
*MUC2 +ve.
  
 
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===Sign out===

Revision as of 01:06, 13 September 2012

The Ampulla of Vater, also hepatopancreatic ampulla, is found in the duodenum.

Normal histology

Features:[1]

  • +/-Pancreatic heterotopia - common.
  • +/-Gastric heterotopia - not common.

Ampullary tumours

  • AKA tumours of the ampulla of Vater.
  • AKA tumours of the hepatopancreatic ampulla.

Ampullary adenoma

General

Microscopic

Features:

  • +/-Paneth cells - may be prominent.[2]

Ampullary carcinoma

General

Microscopic

Features:

  • Dependent on subtype.

Notes:

  • May lack desmoplastic stroma.[5]

Main subtypes:[6]

  • Intestinal ampullary carcinoma.
  • Pancreatobiliary ampullary carcinoma.

IHC

Features:[6]

  • CK7 +ve.
  • CK20 +ve.
  • MUC2 +ve.

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  • Separate CAP protocol.

See also

References

  1. Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 1639. ISBN 978-0781779425.
  2. Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 1640. ISBN 978-0781779425.
  3. Tran, TC.; Vitale, GC. (Dec 2004). "Ampullary tumors: endoscopic versus operative management.". Surg Innov 11 (4): 255-63. PMID 15756395.
  4. Soravia, C.; Berk, T.; Haber, G.; Cohen, Z.; Gallinger, S.. "Management of advanced duodenal polyposis in familial adenomatous polyposis.". J Gastrointest Surg 1 (5): 474-8. PMID 9834381.
  5. Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 1640. ISBN 978-0781779425.
  6. 6.0 6.1 Fischer, HP.; Zhou, H. (2004). "Pathogenesis of carcinoma of the papilla of Vater.". J Hepatobiliary Pancreat Surg 11 (5): 301-9. doi:10.1007/s00534-004-0898-3. PMID 15549428.