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Difference between revisions of "Alpha-1 antitrypsin deficiency"
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Alpha-1 antitrypsin deficiency (view source)
Revision as of 02:59, 26 October 2014
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Alpha-1 antitrypsin deficiency.PAS Diastase.jpg | |||
| Width = | |||
| Caption = Alpha-1 AT deficiency. [[PASD stain]]. | |||
| Synonyms = alpha1-antiprotease inhibitor deficiency | |||
| Micro = +/-pink globules in zone 1 (periportal), +/-fibrosis or [[cirrhosis]] | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = PASD +ve (pink globules in zone 1) - not seen in children | |||
| IHC = A1-AT +ve globules | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[liver]] - see ''[[medical liver disease]]'', [[lung]] - see ''[[emphysema]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon (1 in 2000-5000) | |||
| Bloodwork = | |||
| Rads = emphysematous changes (chest x-ray) | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Alpha-1 antitrypsin deficiency''', abbreviated '''A1-AT''', is a relatively common genetic condition that causes lung and liver pathology. | '''Alpha-1 antitrypsin deficiency''', abbreviated '''A1-AT''', is a relatively common genetic condition that causes lung and liver pathology. | ||