Adenoid cystic/basal cell carcinoma of the prostate
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| Adenoid cystic/basal cell carcinoma of the prostate | |
|---|---|
| Diagnosis in short | |
 Adenoid cystic/basal cell carcinoma of the prostate. H&E stain. | |
| LM DDx | adenoid cystic-like basal cell hyperplasia |
| IHC | BCLA2 +ve, Ki-67 >20, HER2 +ve |
| Grossing notes | prostate biopsy, prostate chips, radical prostatectomy |
| Staging | prostate cancer staging |
| Site | prostate gland |
|
| |
| Prevalence | very rare |
| Prognosis | usually good |
Adenoid cystic/basal cell carcinoma of the prostate, abbreviated ACBCC, is a rare from of prostate cancer that resembles adenoid cystic carcinoma and basal cell carcinoma.
It is also known as adenoid cystic carcinoma of the prostate.[1]
General
- Rare.
- Typically indolent - may be aggressive.[2]
Microscopic
Features:
- Adenoid cystic carcinoma-like and basal cell adenoma-like:
- Nests of cells that have round spaces filled by whispy blue mucin.
- Dense collagenous stroma.
DDx:
- Adenoid cystic-like basal cell hyperplasia[1] - BCL2 -ve, Ki-67 low.[3]
Images
ADBCC - intermed. mag.
ADBCC - intermed. mag.
ADBCC - high mag.
ADBCC - very high mag.
IHC
See also
References
- ↑ 1.0 1.1 1.2 McKenney, JK.; Amin, MB.; Srigley, JR.; Jimenez, RE.; Ro, JY.; Grignon, DJ.; Young, RH. (Oct 2004). "Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.". Am J Surg Pathol 28 (10): 1289-98. PMID 15371944.
- ↑ Iczkowski, KA.; Ferguson, KL.; Grier, DD.; Hossain, D.; Banerjee, SS.; McNeal, JE.; Bostwick, DG. (Dec 2003). "Adenoid cystic/basal cell carcinoma of the prostate: clinicopathologic findings in 19 cases.". Am J Surg Pathol 27 (12): 1523-9. PMID 14657711.
- ↑ 3.0 3.1 3.2 Yang, XJ.; McEntee, M.; Epstein, JI. (Dec 1998). "Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67.". Hum Pathol 29 (12): 1447-50. PMID 9865831.
- ↑ Iczkowski, KA.; Montironi, R. (Dec 2006). "Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu.". J Clin Pathol 59 (12): 1327-30. doi:10.1136/jcp.2005.035147. PMID 17142577.