Adenocarcinoma of the duodenum

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Adenocarcinoma of the duodenum is an uncommon epithelial derived malignancy of the duodenum. It is frequently associated with familial adenomatous polyposis.

It is also known as duodenal adenocarcinoma, duodenal carcinoma and carcinoma of the duodenum.


Risk factors:


  • Mass ulcerating or exophytic.




  • Similar to large bowel adenocarcinomas - see colorectal tumours article.
    • May be similar to gastric adenocarcinomas (gastric-type adenocarcinoma).[1]



  • SMAD4 -ve/+ve.[2]

See also


  1. Kushima, R.; Stolte, M.; Dirks, K.; Vieth, M.; Okabe, H.; Borchard, F.; Hattori, T. (Jun 2002). "Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands.". Virchows Arch 440 (6): 655-9. doi:10.1007/s00428-002-0615-z. PMID 12070607.
  2. Bläker, H.; Aulmann, S.; Helmchen, B.; Otto, HF.; Rieker, RJ.; Penzel, R. (2004). "Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings.". Pathol Res Pract 200 (1): 1-7. PMID 15157044.