Metaphyseal fibrous defect
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| Template:Metaphyseal fibrous defect | |
|---|---|
| Diagnosis in short | |
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| |
| Synonyms | nonossifying fibroma |
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| LM | spindle cells |
| LM DDx | giant cell tumor of bone |
| Syndromes | Jaffe-Campanacci syndrome |
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| Clinical history | Incidental |
| Radiology | Lucent defect in the metaphysis |
General
- Common
- Non-neoplastic
- Self-limited
- Skeletally immature individuals, children and adolescent
- Often small lesions discovered an radiographic incidentaloma
Gross
Firm, granular, brown to yellow to red
Microscopic
Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent.
Stains
IHC
Not relevant