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| Image = Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg | | Image = Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = Clear cell papillary renal cell | | Caption = Clear cell papillary renal cell tumour. [[H&E stain]]. | ||
| Synonyms = clear cell tubulopapillary renal cell carcinoma | | Synonyms = previously known as ''clear cell tubulopapillary renal cell carcinoma'' and ''clear cell papillary renal cell carcinoma'' | ||
| Micro = low ([[ISUP nucleolar grade|ISUP nucleolar]]) grade apical nuclei, clear cells, pseudopapillae, cystic and/or tubular architectures | | Micro = low ([[ISUP nucleolar grade|ISUP nucleolar]]) grade apical nuclei, clear cells, pseudopapillae, cystic and/or tubular architectures | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[clear cell renal cell carcinoma]], [[papillary renal cell carcinoma]],[[Xp11.2 translocation carcinoma]] | | LMDDx = [[clear cell renal cell carcinoma]], [[papillary renal cell carcinoma]], [[Xp11.2 translocation carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CK7 +ve, AMACR -ve, CD10 -ve, TFE3 -ve | | IHC = CK7 +ve, AMACR -ve, CD10 -ve, TFE3 -ve | ||
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| ClinDDx = other [[renal tumours]] | | ClinDDx = other [[renal tumours]] | ||
}} | }} | ||
'''Clear cell papillary renal cell | '''Clear cell papillary renal cell tumour''', abbreviated '''CCPRCT''', is a relatively common benign renal tumour. | ||
It is also known as '''clear cell tubulopapillary renal cell carcinoma''',<ref name=pmid21602815>{{Cite journal | last1 = Rohan | first1 = SM. | last2 = Xiao | first2 = Y. | last3 = Liang | first3 = Y. | last4 = Dudas | first4 = ME. | last5 = Al-Ahmadie | first5 = HA. | last6 = Fine | first6 = SW. | last7 = Gopalan | first7 = A. | last8 = Reuter | first8 = VE. | last9 = Rosenblum | first9 = MK. | title = Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1207-20 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.80 | PMID = 21602815 }}</ref> abbreviated '''CCTPRCC'''. | It was previously known as '''clear cell papillary renal cell carcinoma''', abbreviated '''CCPRCC''' | ||
It is also previously known as '''clear cell tubulopapillary renal cell carcinoma''',<ref name=pmid21602815>{{Cite journal | last1 = Rohan | first1 = SM. | last2 = Xiao | first2 = Y. | last3 = Liang | first3 = Y. | last4 = Dudas | first4 = ME. | last5 = Al-Ahmadie | first5 = HA. | last6 = Fine | first6 = SW. | last7 = Gopalan | first7 = A. | last8 = Reuter | first8 = VE. | last9 = Rosenblum | first9 = MK. | title = Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1207-20 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.80 | PMID = 21602815 }}</ref> abbreviated '''CCTPRCC'''. | |||
==General== | ==General== | ||
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</ref> seen in [[clear cell renal cell carcinoma]]. | </ref> seen in [[clear cell renal cell carcinoma]]. | ||
*Good prognosis. | *Good prognosis. | ||
**On the basis of 268 cases: it has | *Previously classified as ''carcinoma''. | ||
**The name ''clear cell papillary (cyst)adenoma'' | **On the basis of 268 cases: it has was suggested that ''clear cell papillary renal cell carcinoma'' be renamed ''clear cell papillary neoplasm of low malignant potential''.<ref name=pmid26426379>{{Cite journal | last1 = Diolombi | first1 = ML. | last2 = Cheng | first2 = L. | last3 = Argani | first3 = P. | last4 = Epstein | first4 = JI. | title = Do Clear Cell Papillary Renal Cell Carcinomas Have Malignant Potential? | journal = Am J Surg Pathol | volume = 39 | issue = 12 | pages = 1621-34 | month = Dec | year = 2015 | doi = 10.1097/PAS.0000000000000513 | PMID = 26426379 }}</ref> | ||
* | **The name ''clear cell papillary (cyst)adenoma'' was also proposed.<ref name=pmid33223139>{{cite journal |authors=Williamson SR |title=Clear cell papillary renal cell carcinoma: an update after 15 years |journal=Pathology |volume=53 |issue=1 |pages=109–119 |date=January 2021 |pmid=33223139 |doi=10.1016/j.pathol.2020.10.002 |url=}}</ref> | ||
*Relatively common - if one considers it a RCC: it is the fourth most common type.<ref name=pmid24182559>{{Cite journal | last1 = Zhou | first1 = H. | last2 = Zheng | first2 = S. | last3 = Truong | first3 = LD. | last4 = Ro | first4 = JY. | last5 = Ayala | first5 = AG. | last6 = Shen | first6 = SS. | title = Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. | journal = Hum Pathol | volume = | issue = | pages = | month = Oct | year = 2013 | doi = 10.1016/j.humpath.2013.08.004 | PMID = 24182559 }}</ref> | |||
**Most common (in order): [[clear cell RCC]], [[papillary RCC]], [[chromophobe RCC]], clear cell papillary RCC. | **Most common (in order): [[clear cell RCC]], [[papillary RCC]], [[chromophobe RCC]], clear cell papillary RCC. | ||
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===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Clear_cell_papillary_renal_cell_carcinoma_-_high_mag.jpg | | Image:Clear_cell_papillary_renal_cell_carcinoma_-_high_mag.jpg | CCPRCT - high mag. (WC/Nephron) | ||
Image:Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg | | Image:Clear_cell_papillary_renal_cell_carcinoma_-_very_high_mag.jpg | CCPRCT - very high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
www: | www: | ||
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<pre> | <pre> | ||
Left Kidney Mass, Core Biopsy: | Left Kidney Mass, Core Biopsy: | ||
- CLEAR CELL | - CLEAR CELL PAPILARY RENAL CELL TUMOUR, preliminary ISUP nucleolar grade 1 of 4, see comment. | ||
Comment: | Comment: | ||
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NEGATIVE: CD10. | NEGATIVE: CD10. | ||
The findings are in keeping with clear cell tubulopapillary renal cell carcinoma. | The findings are in keeping with clear cell tubulopapillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma". | ||
These tumours have a highly favourable clinical behaviour.[1,2] | These tumours have a highly favourable clinical behaviour.[1,2] | ||
1. Am J Surg Pathol. 2015 Dec;39(12):1621-34. DOI: 10.1097/PAS.0000000000000513 | 1. Am J Surg Pathol. 2015 Dec;39(12):1621-34. DOI: 10.1097/PAS.0000000000000513 | ||
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*[[Kidney tumours]]. | *[[Kidney tumours]]. | ||
*[[Tubulocystic carcinoma of the kidney]]. | *[[Tubulocystic carcinoma of the kidney]]. | ||
*[[ | *[[ELOC-mutated renal cell carcinoma]]. | ||
==References== | ==References== |
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