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| Micro = thickening of seminiferous tubule basement membrane, decreased sperm/no sperm present, +/-intertubular fibrosis | | Micro = thickening of seminiferous tubule basement membrane, decreased sperm/no sperm present, +/-intertubular fibrosis | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[sertoli cell nodule]], [[testicular scar]], [[germ cell neoplasia in situ]], [[seminoma]] - esp. intertubular | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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*Sertoli cells may have a cytoplasm with eosinophilic granules (lysosomes). This is a nonspecific finding described in several contexts.<ref name=pmid1672120>{{Cite journal | last1 = Nistal | first1 = M. | last2 = Garcia-Rodeja | first2 = E. | last3 = Paniagua | first3 = R. | title = Granular transformation of Sertoli cells in testicular disorders. | journal = Hum Pathol | volume = 22 | issue = 2 | pages = 131-7 | month = Feb | year = 1991 | doi = | PMID = 1672120 }}</ref> | *Sertoli cells may have a cytoplasm with eosinophilic granules (lysosomes). This is a nonspecific finding described in several contexts.<ref name=pmid1672120>{{Cite journal | last1 = Nistal | first1 = M. | last2 = Garcia-Rodeja | first2 = E. | last3 = Paniagua | first3 = R. | title = Granular transformation of Sertoli cells in testicular disorders. | journal = Hum Pathol | volume = 22 | issue = 2 | pages = 131-7 | month = Feb | year = 1991 | doi = | PMID = 1672120 }}</ref> | ||
DDx: | |||
*[[Sertoli cell nodule]]. | *[[Sertoli cell nodule]]. | ||
*[[Testicular scar]]. | *[[Testicular scar]]. | ||
*[[ | *[[Germ cell neoplasia in situ]] (intratubular germ cell neoplasia). | ||
*[[Seminoma]]. | *[[Seminoma]] - especially where intertubular growth is predominant.<ref name=pmid15316315>{{Cite journal | last1 = Henley | first1 = JD. | last2 = Young | first2 = RH. | last3 = Wade | first3 = CL. | last4 = Ulbright | first4 = TM. | title = Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. | journal = Am J Surg Pathol | volume = 28 | issue = 9 | pages = 1163-8 | month = Sep | year = 2004 | doi = | PMID = 15316315 }}</ref> | ||
===Images=== | ===Images=== | ||
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TESTICLE, RIGHT, ORCHIECTOMY: | TESTICLE, RIGHT, ORCHIECTOMY: | ||
- ATROPHIC TESTICLE. | - ATROPHIC TESTICLE. | ||
- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA. | - NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA). | ||
- NEGATIVE FOR MALIGNANCY. | - NEGATIVE FOR MALIGNANCY. | ||
</pre> | </pre> |
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