Post-transplant lymphoproliferative disorder

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Post-transplant lymphoproliferative disorder, vbbreviated PTLD, is something afflicts people that had transplants (solid organ and bone marrow). It is essentially a type of B-cell lymphoma.

General

  • Rare.
  • B cell neoplasm associated with EBV.[1][2]
  • Commonly in the GI tract as it gets the most immunosuppression; immunosuppressives are taken orally -- not cleaned by the liver prior to reaching the GI tract.

Microscopic

Features:

  • Similar to large cell lymphomas:
    • Large lymphoid cells with a diameter ~2x a resting lymphocyte.
    • Nucleoli.

IHC

  • B cell markers +ve
  • EBER +ve -- diffuse.

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/431364-overview. Accessed on: 10 February 2011.
  2. ↑ Gottschalk S, Rooney CM, Heslop HE (2005). "Post-transplant lymphoproliferative disorders". Annu. Rev. Med. 56: 29–44. doi:10.1146/annurev.med.56.082103.104727. PMID 15660500.
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