P16

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p16 is a commonly used immunostain. It can be considered a surrogate marker for HPV infection. p16, like most other "p" stains, is a nuclear stain.

HSIL showing the characteristic p16 staining.

Pattern

  • Nuclear stain +/- cytoplasmic staining.

Use

Tumours

Positive

  • Squamous cell carcinoma - esp. cervical SCC, anal SCC, penile SCC, HPV-associated head and neck SCC.
  • High grade urothelial carcinoma ~86% of cases.[1]

Negative

  • Breast carcinoma.
  • Prostate carcinoma.
  • Lung squamous cell carcinoma.[1]

References

  1. 1.0 1.1 Piaton, E.; Casalegno, JS.; Advenier, AS.; Decaussin-Petrucci, M.; Mege-Lechevallier, F.; Ruffion, A.; Mekki, Y. (Oct 2014). "p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.". Cancer Cytopathol 122 (10): 760-9. doi:10.1002/cncy.21462. PMID 25069600.

External links