Difference between revisions of "Juvenile granulosa cell tumour"

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==General==
==General==
*May secrete estrogen.
*Uncommon.<ref name=pmid23033282>{{Cite journal  | last1 = Oztekin | first1 = D. | last2 = Kurt | first2 = S. | last3 = Camuzcuoglu | first3 = H. | last4 = Balsak | first4 = D. | last5 = Dicle | first5 = N. | last6 = Tinar | first6 = S. | title = Granulosa cell tumors of the ovary: review of 43 cases. | journal = J BUON | volume = 17 | issue = 3 | pages = 461-4 | month = | year = | doi =  | PMID = 23033282 }}</ref>
**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]].
**May present as precocious puberty.<ref name=pmid21526089>{{Cite journal  | last1 = Hashemipour | first1 = M. | last2 = Moaddab | first2 = MH. | last3 = Nazem | first3 = M. | last4 = Mahzouni | first4 = P. | last5 = Salek | first5 = M. | title = Granulosa cell tumor in a six-year-old girl presented as precocious puberty. | journal = J Res Med Sci | volume = 15 | issue = 4 | pages = 240-2 | month = Jul | year = 2010 | doi =  | PMID = 21526089 }}</ref>
*Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref>
*Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref>
*Uncommon.<ref name=pmid23033282>{{Cite journal  | last1 = Oztekin | first1 = D. | last2 = Kurt | first2 = S. | last3 = Camuzcuoglu | first3 = H. | last4 = Balsak | first4 = D. | last5 = Dicle | first5 = N. | last6 = Tinar | first6 = S. | title = Granulosa cell tumors of the ovary: review of 43 cases. | journal = J BUON | volume = 17 | issue = 3 | pages = 461-4 | month = | year = | doi =  | PMID = 23033282 }}</ref>
 
May secrete estrogen - can present with:
*Endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]].
*Precocious puberty.<ref name=pmid21526089>{{Cite journal  | last1 = Hashemipour | first1 = M. | last2 = Moaddab | first2 = MH. | last3 = Nazem | first3 = M. | last4 = Mahzouni | first4 = P. | last5 = Salek | first5 = M. | title = Granulosa cell tumor in a six-year-old girl presented as precocious puberty. | journal = J Res Med Sci | volume = 15 | issue = 4 | pages = 240-2 | month = Jul | year = 2010 | doi =  | PMID = 21526089 }}</ref>
 
Prognosis - granulosa cell tumours (adult and juvenile):<ref name=pmid23033282/>
*Low-stage: 97% five year survival.
*High-stage: 67% five year survival.


==Gross==
==Gross==

Revision as of 04:05, 18 February 2014

Juvenile granulosa cell tumour
Diagnosis in short

Juvenile granulosa cell tumour. H&E stain.
LM microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm
LM DDx Brenner tumour
IHC inhibin +ve, calretinin +ve
Gross mass lesion, solid
Site ovary - ovarian tumours
Associated Dx endometrial hyperplasia, endometrioid endometrial carcinoma
Symptoms +/-menorrhagia
Prevalence uncommon
Prognosis good to moderate (dependent on stage)
Treatment surgery

Juvenile granulosa cell tumour is an uncommon ovarian tumour in the sex cord stromal tumours group.

General

  • Uncommon.[1]
  • Reported in males.[2]

May secrete estrogen - can present with:

Prognosis - granulosa cell tumours (adult and juvenile):[1]

  • Low-stage: 97% five year survival.
  • High-stage: 67% five year survival.

Gross

  • Classically solid.

Microscopic

Features:

  • Microcystic spaces.
  • Moderate-to-marked nuclear atypia.
  • Cuboidal-to-polygonal cell in sheets or stands or cords.
  • Basophilic cytoplasm.

Notes:

  • Juvenile variant of GCT has more nuclear pleomorphism.

DDx:

Images

  • Juvenile granulosa cell tumour - intermed. mag. (WC)

  • Juvenile granulosa cell tumour - high mag. (WC)

  • Juvenile granulosa cell tumour - very high mag. (WC)

IHC

Molecular

Currently not used for the diagnosis.

See also

References

  1. ↑ 1.0 1.1 Oztekin, D.; Kurt, S.; Camuzcuoglu, H.; Balsak, D.; Dicle, N.; Tinar, S.. "Granulosa cell tumors of the ovary: review of 43 cases.". J BUON 17 (3): 461-4. PMID 23033282.
  2. ↑ URL: http://path.upmc.edu/cases/case631.html. Accessed on: 26 January 2012.
  3. ↑ Hashemipour, M.; Moaddab, MH.; Nazem, M.; Mahzouni, P.; Salek, M. (Jul 2010). "Granulosa cell tumor in a six-year-old girl presented as precocious puberty.". J Res Med Sci 15 (4): 240-2. PMID 21526089.
  4. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1102. ISBN 0-7216-0187-1.
  5. ↑ Schofield, DE.; Fletcher, JA. (Dec 1992). "Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.". Am J Pathol 141 (6): 1265-9. PMID 1466394.
  6. ↑ Mayr, D.; Kaltz-Wittmer, C.; Arbogast, S.; Amann, G.; Aust, DE.; Diebold, J. (Sep 2002). "Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors.". Mod Pathol 15 (9): 951-7. doi:10.1097/01.MP.0000024290.55261.14. PMID 12218213.
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