Difference between revisions of "Diffuse astrocytoma, MYB- or MYBL-altered"
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Jensflorian (talk | contribs) (Imaging * gross) |
Jensflorian (talk | contribs) (+IHC + MOL) |
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* Minimal incereased cell density. | * Minimal incereased cell density. | ||
* Monomorphic, bland glial cells. | * Monomorphic, bland glial cells. | ||
* | * Entrapped neurons. | ||
* Usu. no mitotic activity | |||
Notes: | Notes: | ||
* | *Focally angiocentric pattern may be present. | ||
DDx | DDx | ||
Line 76: | Line 73: | ||
==IHC== | ==IHC== | ||
Features: | Features: | ||
*GFAP +ve | *GFAP +ve. | ||
*Olig2 -ve. | |||
*MAP2 -ve. | |||
*CD34 -ve. | |||
*ATRX retained. | |||
==Molecular== | ==Molecular== | ||
* | * Structural variant of MYB or MYBL1 (most common fusion partners: MAML2, MMP16 , PCDGHA1).<ref>{{cite journal |vauthors=Qaddoumi I, Orisme W, Wen J, Santiago T, Gupta K, Dalton JD, Tang B, Haupfear K, Punchihewa C, Easton J, Mulder H, Boggs K, Shao Y, Rusch M, Becksfort J, Gupta P, Wang S, Lee RP, Brat D, Peter Collins V, Dahiya S, George D, Konomos W, Kurian KM, McFadden K, Serafini LN, Nickols H, Perry A, Shurtleff S, Gajjar A, Boop FA, Klimo PD, Mardis ER, Wilson RK, Baker SJ, Zhang J, Wu G, Downing JR, Tatevossian RG, Ellison DW |title=Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology |journal=Acta Neuropathol |volume=131 |issue=6 |pages=833–45 |date=June 2016 |pmid=26810070 |pmc=4866893 |doi=10.1007/s00401-016-1539-z |url=}}</ref> | ||
* IDH1/2 wildtype. | |||
* H3F3A wildtype. | |||
==Prognosis== | ==Prognosis== |