Difference between revisions of "Glycogenic acanthosis of the esophagus"

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(+stains)
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| Subtypes  =
| Subtypes  =
| LMDDx      =
| LMDDx      =
| Stains    =
| Stains    = PAS +ve, PASD -ve
| IHC        =
| IHC        =
| EM        =
| EM        =
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====www====
====www====
*[http://scielo.isciii.es/pdf/diges/v102n5/carta3.pdf Glycogenic acanthosis (isciii.es)].
*[http://scielo.isciii.es/pdf/diges/v102n5/carta3.pdf Glycogenic acanthosis (isciii.es)].
==Stains==
Features:<ref name=pmid6981928>{{Cite journal  | last1 = Glick | first1 = SN. | last2 = Teplick | first2 = SK. | last3 = Goldstein | first3 = J. | last4 = Stead | first4 = JA. | last5 = Zitomer | first5 = N. | title = Glycogenic acanthosis of the esophagus. | journal = AJR Am J Roentgenol | volume = 139 | issue = 4 | pages = 683-8 | month = Oct | year = 1982 | doi = 10.2214/ajr.139.4.683 | PMID = 6981928 }}</ref>
*[[PAS stain|PAS]] +ve.
*[[PASD stain|PASD]] -ve.


==See also==
==See also==

Revision as of 10:38, 16 May 2015

Glycogenic acanthosis of the esophagus
Diagnosis in short

Glycogenic acanthosis of the esophagus. H&E stain.

LM squamous epithelium with (1) superficial clearing of the cytoplasm, and (2) thickening
Stains PAS +ve, PASD -ve
Site esophagus

Associated Dx possibly associated with gastroesophageal reflux disease
Syndromes possibly Cowden's disease when diffuse

Clinical history ingestion of hot liquids (???)
Prevalence uncommon
Endoscopy raised grey/white lesions
Prognosis benign

Glycogenic acanthosis of the esophagus, abbreviated GAE, is an uncommon benign change of the esophagus with a distinctive endoscopic appearance.

General

  • Uncommon - seen 3.5% of consecutive 2328 upper endoscopies.[1]
  • Benign.[2]
  • May be associated with GERD;[1][3] however, lesions do not resolve with PPI treatment.[2]
  • Possible association with ingestion of hot liquids.[4]
  • Described in the context of Cowden's disease when seen diffusely.[5]

Gross/endoscopic

  • Distinctive endoscopic appearance - grey/white raised lesion.[4]

Image

Microscopic

Features:[4]

  • Squamous epithelium with:
    • Superficial clearing of the cytoplasm.
    • Thickening.

Images

www

Stains

Features:[6]

See also

References

  1. 1.0 1.1 Vadva, MD.; Triadafilopoulos, G. (Jul 1993). "Glycogenic acanthosis of the esophagus and gastroesophageal reflux.". J Clin Gastroenterol 17 (1): 79-83. PMID 8409304.
  2. 2.0 2.1 2.2 Tsai, SJ.; Lin, CC.; Chang, CW.; Hung, CY.; Shieh, TY.; Wang, HY.; Shih, SC.; Chen, MJ. (Jan 2015). "Benign esophageal lesions: endoscopic and pathologic features.". World J Gastroenterol 21 (4): 1091-8. doi:10.3748/wjg.v21.i4.1091. PMID 25632181.
  3. Nazligül, Y.; Aslan, M.; Esen, R.; Yeniova, AÖ.; Kefeli, A.; Küçükazman, M.; Dülger, AC.; Celik, Y. (Jun 2012). "Benign glycogenic acanthosis lesions of the esophagus.". Turk J Gastroenterol 23 (3): 199-202. PMID 22798107.
  4. 4.0 4.1 4.2 Lopes, S.; Figueiredo, P.; Amaro, P.; Freire, P.; Alves, S.; Cipriano, MA.; Gouveia, H.; Sofia, C. et al. (May 2010). "Glycogenic acanthosis of the esophagus: an unusually endoscopic appearance.". Rev Esp Enferm Dig 102 (5): 341-2. PMID 20524767.
  5. Kay, PS.; Soetikno, RM.; Mindelzun, R.; Young, HS. (Jun 1997). "Diffuse esophageal glycogenic acanthosis: an endoscopic marker of Cowden's disease.". Am J Gastroenterol 92 (6): 1038-40. PMID 9177527.
  6. Glick, SN.; Teplick, SK.; Goldstein, J.; Stead, JA.; Zitomer, N. (Oct 1982). "Glycogenic acanthosis of the esophagus.". AJR Am J Roentgenol 139 (4): 683-8. doi:10.2214/ajr.139.4.683. PMID 6981928.