Difference between revisions of "Intramucosal colorectal carcinoma"

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[[Image:GI Organization.svg|thumb|300px|right|The layers of the GI tract from inside (mucosa) to outside (serosa/adventitia). (WC)]]
'''Intramucosal colorectal carcinoma''' is a confusing term for ''high grade (colorectal) dysplasia'' that should be avoided.<ref name=pmid22943008>{{Cite journal  | last1 = Fleming | first1 = M. | last2 = Ravula | first2 = S. | last3 = Tatishchev | first3 = SF. | last4 = Wang | first4 = HL. | title = Colorectal carcinoma: Pathologic aspects. | journal = J Gastrointest Oncol | volume = 3 | issue = 3 | pages = 153-73 | month = Sep | year = 2012 | doi = 10.3978/j.issn.2078-6891.2012.030 | PMID = 22943008 }}</ref>
'''Intramucosal colorectal carcinoma''' is a confusing term for ''high grade (colorectal) dysplasia'' that should be avoided.<ref name=pmid22943008>{{Cite journal  | last1 = Fleming | first1 = M. | last2 = Ravula | first2 = S. | last3 = Tatishchev | first3 = SF. | last4 = Wang | first4 = HL. | title = Colorectal carcinoma: Pathologic aspects. | journal = J Gastrointest Oncol | volume = 3 | issue = 3 | pages = 153-73 | month = Sep | year = 2012 | doi = 10.3978/j.issn.2078-6891.2012.030 | PMID = 22943008 }}</ref>


''Intramucosal rectal carcinoma'', ''intramucosal colonic carcinoma'', ''intramucosal colonic adenocarcinoma'' and ''intramucosal rectal adenocarcinoma'' redirect here.
'''Intramucosal rectal carcinoma''', '''intramucosal colonic carcinoma''', '''intramucosal colonic adenocarcinoma''', '''intramucosal rectal adenocarcinoma''', '''intramucosal adenocarcinoma of the colon‎''', and '''colorectal adenocarcinoma in situ''' redirect here.


==Background==
==Background==
*[[Colorectal adenocarcinoma]] is defined by invasion into the submucosa.  
*[[Colorectal adenocarcinoma]] is defined by invasion into the submucosa.  
**This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria.
**This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria.
**Rationale: nasty (cancer-like) cells in lamina propria do ''not'' have [[metastasis|metastatic]] potential as there are no lymphatics in the colorectal lamina propria.<ref>{{Cite journal  | last1 = Lewin | first1 = MR. | last2 = Fenton | first2 = H. | last3 = Burkart | first3 = AL. | last4 = Sheridan | first4 = T. | last5 = Abu-Alfa | first5 = AK. | last6 = Montgomery | first6 = EA. | title = Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1882-6 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e318057fac2 | PMID = 18043043 }}</ref>  
**Rationale: atypical (cancer-like) cells in lamina propria do ''not'' have [[metastasis|metastatic]] potential as there are no lymphatics in the colorectal lamina propria.<ref>{{Cite journal  | last1 = Lewin | first1 = MR. | last2 = Fenton | first2 = H. | last3 = Burkart | first3 = AL. | last4 = Sheridan | first4 = T. | last5 = Abu-Alfa | first5 = AK. | last6 = Montgomery | first6 = EA. | title = Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1882-6 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e318057fac2 | PMID = 18043043 }}</ref>
 
Note:
*If one wants to differentiate ''adenocarcinoma in situ'' and ''high-grade dysplasia'':
**''Adenocarcinoma in situ'' has ''invasion into the lamina propria'' and ''high-grade dysplasia'' does ''not'' have lamina propria invasion. Thus, the difference amounts to seeing a [[desmoplastic stroma]] or infiltrative cells; if one of these is present it is ''adenocarcinoma in situ'', if both are ''not'' it is ''dysplasia''.


==See also==
==See also==
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*[[Traditional adenoma]].
*[[Traditional adenoma]].
*[[Intramucosal carcinoma]].
*[[Intramucosal carcinoma]].
*[[Colorectal cancer staging]].
*[[Pseudoinvasion]].


==References==
==References==

Latest revision as of 06:29, 19 March 2018

The layers of the GI tract from inside (mucosa) to outside (serosa/adventitia). (WC)

Intramucosal colorectal carcinoma is a confusing term for high grade (colorectal) dysplasia that should be avoided.[1]

Intramucosal rectal carcinoma, intramucosal colonic carcinoma, intramucosal colonic adenocarcinoma, intramucosal rectal adenocarcinoma, intramucosal adenocarcinoma of the colon‎, and colorectal adenocarcinoma in situ redirect here.

Background

  • Colorectal adenocarcinoma is defined by invasion into the submucosa.
    • This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria.
    • Rationale: atypical (cancer-like) cells in lamina propria do not have metastatic potential as there are no lymphatics in the colorectal lamina propria.[2]

Note:

  • If one wants to differentiate adenocarcinoma in situ and high-grade dysplasia:
    • Adenocarcinoma in situ has invasion into the lamina propria and high-grade dysplasia does not have lamina propria invasion. Thus, the difference amounts to seeing a desmoplastic stroma or infiltrative cells; if one of these is present it is adenocarcinoma in situ, if both are not it is dysplasia.

See also

References

  1. Fleming, M.; Ravula, S.; Tatishchev, SF.; Wang, HL. (Sep 2012). "Colorectal carcinoma: Pathologic aspects.". J Gastrointest Oncol 3 (3): 153-73. doi:10.3978/j.issn.2078-6891.2012.030. PMID 22943008.
  2. Lewin, MR.; Fenton, H.; Burkart, AL.; Sheridan, T.; Abu-Alfa, AK.; Montgomery, EA. (Dec 2007). "Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases.". Am J Surg Pathol 31 (12): 1882-6. doi:10.1097/PAS.0b013e318057fac2. PMID 18043043.