Difference between revisions of "Pulmonary cytopathology"

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Pulmonary cytopathology (view source)

Revision as of 18:59, 10 March 2022

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There is a proposed standard for EBUS specimens:<ref name=pmid22246929>{{Cite journal  | last1 = Nayak | first1 = A. | last2 = Sugrue | first2 = C. | last3 = Koenig | first3 = S. | last4 = Wasserman | first4 = PG. | last5 = Hoda | first5 = S. | last6 = Morgenstern | first6 = NJ. | title = Endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA): a proposal for on-site adequacy criteria. | journal = Diagn Cytopathol | volume = 40 | issue = 2 | pages = 128-37 | month = Feb | year = 2012 | doi = 10.1002/dc.21517 | PMID = 22246929 }}</ref>
There is a proposed standard for EBUS specimens:<ref name=pmid22246929>{{Cite journal  | last1 = Nayak | first1 = A. | last2 = Sugrue | first2 = C. | last3 = Koenig | first3 = S. | last4 = Wasserman | first4 = PG. | last5 = Hoda | first5 = S. | last6 = Morgenstern | first6 = NJ. | title = Endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA): a proposal for on-site adequacy criteria. | journal = Diagn Cytopathol | volume = 40 | issue = 2 | pages = 128-37 | month = Feb | year = 2012 | doi = 10.1002/dc.21517 | PMID = 22246929 }}</ref>
*> 5 low power fields (×10 objective) with >= 100 lymphocytes and < 2 groups of bronchial cells.
*> 5 low power fields (×10 objective) with >= 100 lymphocytes and < 2 groups of bronchial cells.
Note:
*A simplified version: 5 fields of view x 100 cells/1 field of view = 500 cells.


===Other specimens===
===Other specimens===
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Image: Bronchial epithelium with inflammation - alt -- very high mag.jpg | BBE - very high mag.
Image: Bronchial epithelium with inflammation - alt -- very high mag.jpg | BBE - very high mag.
</gallery>
</gallery>
www:
<gallery>
Image: Reactive bronchial cells -- very high mag.jpg | RBCs - very high mag.
Image: Reactive bronchial cells -- extremely high mag.jpg | RBCs - extremely high mag.
</gallery>
=====www=====
*[http://www.cytologystuff.com/gallery/images_large/slide0612.jpg Reactive bronchial cells (cytologystuff.com)].<ref>URL: [http://www.cytologystuff.com/study/section12ng.htm http://www.cytologystuff.com/study/section12ng.htm]. Accessed on: 19 August 2015.</ref>
*[http://www.cytologystuff.com/gallery/images_large/slide0612.jpg Reactive bronchial cells (cytologystuff.com)].<ref>URL: [http://www.cytologystuff.com/study/section12ng.htm http://www.cytologystuff.com/study/section12ng.htm]. Accessed on: 19 August 2015.</ref>


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Features:
Features:
*Casts of frothy material/large proteinaceous debris - approximately the size of an alveolus.
*Casts of frothy material/large proteinaceous debris - approximately the size of an alveolus.
DDx:
*[[Pulmonary alveolar proteinosis]].


==Aspergillosis==
==Aspergillosis==
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| '''Present'''
| '''Present'''
| Present r/i squamous (strong)
| Present r/i squamous (strong)
|-
| Image
| [[Image:Lung small cell carcinoma -- extremely high mag.jpg|thumb|center|120px|SmCC - Pap stain. (WC)]]
| [[Image:Lung adenocarcinoma - Pap stain -- very high mag.jpg|thumb|center|120px|LA - Pap stain. (WC)]]
| [[Image:Squamous carcinoma - lung FNA -- very high mag.jpg|thumb|center|120px|SCC - Pap stain. (WC)]]
| <!-- Value -->
|}
|}


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**AAH has a size criterion, ergo not really possible to diagnose on cytopathology specimen.
**AAH has a size criterion, ergo not really possible to diagnose on cytopathology specimen.
*Vegetable cell - contaminant.<ref name=pmid8384547>{{Cite journal  | last1 = Naryshkin | first1 = S. | last2 = Young | first2 = NA. | title = Respiratory cytology: a review of non-neoplastic mimics of malignancy. | journal = Diagn Cytopathol | volume = 9 | issue = 1 | pages = 89-97 | month =  | year = 1993 | doi =  | PMID = 8384547 }}</ref>
*Vegetable cell - contaminant.<ref name=pmid8384547>{{Cite journal  | last1 = Naryshkin | first1 = S. | last2 = Young | first2 = NA. | title = Respiratory cytology: a review of non-neoplastic mimics of malignancy. | journal = Diagn Cytopathol | volume = 9 | issue = 1 | pages = 89-97 | month =  | year = 1993 | doi =  | PMID = 8384547 }}</ref>
====Images====
<gallery>
Image: Lung adenocarcinoma - Pap stain -- high mag.jpg | LA - Pap - high mag. (WC)
Image: Lung adenocarcinoma - Pap stain -- very high mag.jpg | LA - Pap - very high mag. (WC)
Image: Lung adenocarcinoma - Pap stain - alt -- very high mag.jpg | LA - Pap - very high mag. (WC)
Image: Lung adenocarcinoma - Diff-Quik -- high mag.jpg | LA - [[Diff-Quik stain|DQ]] - high mag. (WC)
Image: Lung adenocarcinoma - Diff-Quik -- very high mag.jpg | LA - DQ - very high mag. (WC)
</gallery>


==Neuroendocrine tumours==
==Neuroendocrine tumours==
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====Image====
====Image====
=====Case 1=====
<gallery>
Image:Small_cell_lung_cancer_-_cytology.jpg | SmCC showing nuclear moulding - [[Field stain]]. (WC)
</gallery>
=====Case 2=====
<gallery>
Image: Lung small cell carcinoma - Diff-Quik -- high mag.jpg | SmCC - [[Diff-Quik]] - high mag. (WC)
Image: Lung small cell carcinoma - Diff-Quik -- very high mag.jpg | SmCC - Diff-Quik - very high mag. (WC)
Image: Lung small cell carcinoma - Diff-Quik -- extremely high mag.jpg | SmCC - Diff-Quik - extremely high mag. (WC)
Image: Lung small cell carcinoma -- very high mag.jpg | SmCC - [[Pap stain]] - very high mag. (WC)
Image: Lung small cell carcinoma -- extremely high mag.jpg | SmCC - Pap stain - extremely high mag. (WC)
</gallery>
=====Case 3=====
<gallery>
<gallery>
Image:Small_cell_lung_cancer_-_cytology.jpg | Small cell carcinoma showing nuclear moulding. (WC)
Image: Small cell carcinoma - BRB -- high mag.jpg | SmCC - high mag.
Image: Small cell carcinoma - BRB - alt -- high mag.jpg | SmCC - high mag.
Image: Small cell carcinoma - BRB - alt 2 -- high mag.jpg | SmCC - high mag.
 
Image: Small cell carcinoma - BRB -- very high mag.jpg | SmCC - very high mag.
Image: Small cell carcinoma - BRB - alt -- very high mag.jpg | SmCC - very high mag.
Image: Small cell carcinoma - BRB - alt 2 -- very high mag.jpg | SmCC - very high mag.
 
Image: Small cell carcinoma - BRB -- very high mag.gif | SmCC - high very mag.
</gallery>
</gallery>


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====Image====
====Image====
=====Case 1=====
<gallery>
<gallery>
Image:Squamous_carcinoma_lung_1_cytology.jpg |SCC. (WC)
Image:Squamous_carcinoma_lung_2_cytology.jpg |SCC. (WC)
Image:Squamous_carcinoma_lung_2_cytology.jpg |SCC. (WC)
</gallery>
=====Case 2=====
<gallery>
Image: Squamous carcinoma - lung FNA -- high mag.jpg | SCC - high mag.
Image: Squamous carcinoma - lung FNA - alt -- high mag.jpg | SCC - high mag.
Image: Squamous carcinoma - lung FNA -- very high mag.jpg | SCC - very high mag.
Image: Squamous carcinoma - lung FNA - alt -- very high mag.jpg | SCC - very high mag.
Image: Squamous carcinoma - lung FNA -- high and very high mag - animation.gif | SCC animation - very high mag.
Image: Squamous carcinoma - lung FNA -- extremely high mag.jpg | SCC - extremely high mag.
Image: Squamous carcinoma - lung FNA - alt 2 -- extremely high mag.jpg | SCC - extremely high mag.
</gallery>
</gallery>


Michael
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