Difference between revisions of "Invasive cribriform carcinoma of the breast"

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'''Invasive cribriform carcinoma of the breast''' is a rare type of [[breast cancer]] with a favourable prognosis.<ref>{{Cite journal  | last1 = Cong | first1 = Y. | last2 = Qiao | first2 = G. | last3 = Zou | first3 = H. | last4 = Lin | first4 = J. | last5 = Wang | first5 = X. | last6 = Li | first6 = X. | last7 = Li | first7 = Y. | last8 = Zhu | first8 = S. | title = Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. | journal = Oncol Lett | volume = 9 | issue = 4 | pages = 1753-1758 | month = Apr | year = 2015 | doi = 10.3892/ol.2015.2972 | PMID = 25789036 }}</ref>
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Breast CribriformCarcinoma MP SNP.jpg
| Width      =
| Caption    = Invasive cribriform carcinoma of the breast. [[H&E stain]].
| Synonyms  =
| Micro      = cribriform architecture, stromal desmoplasia, +/-tubular component
| Subtypes  =
| LMDDx      = [[tubular carcinoma of the breast|tubular carcinoma]], cribriform [[DCIS]], mixed tumour (e.g. ICC with [[invasive ductal carcinoma of the breast|IDC]]), [[adenoid cystic carcinoma of the breast]]
| Stains    =
| IHC        = ER +ve, PR +ve, HER2 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[breast]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
| Tx        = surgical
}}
'''Invasive cribriform carcinoma of the breast''' is a rare type of [[breast cancer]] with a favourable prognosis.<ref name=pmid25789036>{{Cite journal  | last1 = Cong | first1 = Y. | last2 = Qiao | first2 = G. | last3 = Zou | first3 = H. | last4 = Lin | first4 = J. | last5 = Wang | first5 = X. | last6 = Li | first6 = X. | last7 = Li | first7 = Y. | last8 = Zhu | first8 = S. | title = Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. | journal = Oncol Lett | volume = 9 | issue = 4 | pages = 1753-1758 | month = Apr | year = 2015 | doi = 10.3892/ol.2015.2972 | PMID = 25789036 }}</ref>


==General==
==General==
*Rare.
*Rare ~ 0.6% of breast cancer in one series.<ref>{{Cite journal  | last1 = Stutz | first1 = JA. | last2 = Evans | first2 = AJ. | last3 = Pinder | first3 = S. | last4 = Ellis | first4 = IO. | last5 = Yeoman | first5 = LJ. | last6 = Wilson | first6 = AR. | last7 = Sibbering | first7 = DM. | title = The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team. | journal = Clin Radiol | volume = 49 | issue = 10 | pages = 693-5 | month = Oct | year = 1994 | doi =  | PMID = 7955831 }}</ref>
*Low Grade.
*Low grade.
*Good prognosis if pure or associated with a tubular invasive component.<ref name=pmid6884999>{{Cite journal  | last1 = Page | first1 = DL. | last2 = Dixon | first2 = JM. | last3 = Anderson | first3 = TJ. | last4 = Lee | first4 = D. | last5 = Stewart | first5 = HJ. | title = Invasive cribriform carcinoma of the breast. | journal = Histopathology | volume = 7 | issue = 4 | pages = 525-36 | month = Jul | year = 1983 | doi =  | PMID = 6884999 }}</ref>
*Good prognosis if pure or associated with a tubular invasive component.<ref name=pmid6884999>{{Cite journal  | last1 = Page | first1 = DL. | last2 = Dixon | first2 = JM. | last3 = Anderson | first3 = TJ. | last4 = Lee | first4 = D. | last5 = Stewart | first5 = HJ. | title = Invasive cribriform carcinoma of the breast. | journal = Histopathology | volume = 7 | issue = 4 | pages = 525-36 | month = Jul | year = 1983 | doi =  | PMID = 6884999 }}</ref>


==Microscopic==
==Microscopic==
Features:<ref name=pmid23412348/>
*[[Cribriform]] (or sieve-like) architecture.
*[[Desmoplastic stroma]].
*+/-[[Tubular carcinoma of the breast|Tubular]] component.
Notes:
*Cribriform component should be >90% of the tumour.<ref name=pmid23412348>{{Cite journal  | last1 = Zhang | first1 = W. | last2 = Zhang | first2 = T. | last3 = Lin | first3 = Z. | last4 = Zhang | first4 = X. | last5 = Liu | first5 = F. | last6 = Wang | first6 = Y. | last7 = Liu | first7 = H. | last8 = Yang | first8 = Y. | last9 = Niu | first9 = Y. | title = Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. | journal = Int J Clin Exp Pathol | volume = 6 | issue = 3 | pages = 445-57 | month =  | year = 2013 | doi =  | PMID = 23412348  | PMC = 3563205}}</ref>
*Low or intermediate Nottingham grade.
DDx:
*Cribriform [[DCIS]].
*[[Tubular carcinoma of the breast]].
*[[Invasive ductal carcinoma of the breast]] with cribriform component.
*[[Adenoid cystic carcinoma of the breast]].


===Images===
===Images===
Line 14: Line 59:
Image:Breast CribriformCarcinoma HP SNP.jpg|Breast invasive cribriform carcinoma - high power. (SKB)
Image:Breast CribriformCarcinoma HP SNP.jpg|Breast invasive cribriform carcinoma - high power. (SKB)
</gallery>
</gallery>
www:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563205/figure/fig01/ ICC - panels A-C (nih.gov)].<ref name=pmid23412348/>
==IHC==
Features:<ref name=pmid25789036/>
*ER +ve (9 +ve of 9 cases).
*PR +ve (9 +ve of 9 cases).
*HER2 -ve (0 +ve of 9 cases).


==See also==
==See also==

Latest revision as of 03:58, 31 October 2015

Invasive cribriform carcinoma of the breast
Diagnosis in short

Invasive cribriform carcinoma of the breast. H&E stain.
LM cribriform architecture, stromal desmoplasia, +/-tubular component
LM DDx tubular carcinoma, cribriform DCIS, mixed tumour (e.g. ICC with IDC), adenoid cystic carcinoma of the breast
IHC ER +ve, PR +ve, HER2 -ve
Site breast
Prevalence very rare
Prognosis good
Treatment surgical

Invasive cribriform carcinoma of the breast is a rare type of breast cancer with a favourable prognosis.[1]

General

  • Rare ~ 0.6% of breast cancer in one series.[2]
  • Low grade.
  • Good prognosis if pure or associated with a tubular invasive component.[3]

Microscopic

Features:[4]

Notes:

  • Cribriform component should be >90% of the tumour.[4]
  • Low or intermediate Nottingham grade.

DDx:

Images

  • Breast invasive cribriform carcinoma - low power. (SKB)

  • Breast invasive cribriform carcinoma - medium power. (SKB)

  • Breast invasive cribriform carcinoma - high power. (SKB)

www:

IHC

Features:[1]

  • ER +ve (9 +ve of 9 cases).
  • PR +ve (9 +ve of 9 cases).
  • HER2 -ve (0 +ve of 9 cases).

See also

References

  1. ↑ 1.0 1.1 Cong, Y.; Qiao, G.; Zou, H.; Lin, J.; Wang, X.; Li, X.; Li, Y.; Zhu, S. (Apr 2015). "Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature.". Oncol Lett 9 (4): 1753-1758. doi:10.3892/ol.2015.2972. PMID 25789036.
  2. ↑ Stutz, JA.; Evans, AJ.; Pinder, S.; Ellis, IO.; Yeoman, LJ.; Wilson, AR.; Sibbering, DM. (Oct 1994). "The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team.". Clin Radiol 49 (10): 693-5. PMID 7955831.
  3. ↑ Page, DL.; Dixon, JM.; Anderson, TJ.; Lee, D.; Stewart, HJ. (Jul 1983). "Invasive cribriform carcinoma of the breast.". Histopathology 7 (4): 525-36. PMID 6884999.
  4. ↑ 4.0 4.1 4.2 Zhang, W.; Zhang, T.; Lin, Z.; Zhang, X.; Liu, F.; Wang, Y.; Liu, H.; Yang, Y. et al. (2013). "Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified.". Int J Clin Exp Pathol 6 (3): 445-57. PMC 3563205. PMID 23412348. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563205/.
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