Difference between revisions of "Anaplastic thyroid carcinoma"

Revision as of 03:10, 4 March 2015

Anaplastic thyroid carcinoma is a rare aggressive tumour of the thyroid gland.

Epidemiology:

Features:

Notes:

May have features of other thyroid carcinomas, e.g. psammoma bodies, papillae, nuclear changes of PTC.

DDx:

↑ ^1.0 ^1.1 Ordóñez NG, El-Naggar AK, Hickey RC, Samaan NA (July 1991). "Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases". Am. J. Clin. Pathol. 96 (1): 15–24. PMID 1712540.

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-#redirect [[Thyroid_gland#Anaplastic_thyroid_carcinoma]]
+'''Anaplastic thyroid carcinoma''' is a rare aggressive tumour of the [[thyroid gland]].
+==General==
+Epidemiology:
+*Very rare.
+*Horrible prognosis.
+*Often presents with obstruction.
+*Typically there is a history of a thyroid mass.
+==Microscopic==
+Features:
+*Cytologically malignant:
+**Huge [[NC ratio]].
+**Mitoses.
+*+/-[[Necrosis]].
+Notes:
+*May have features of other thyroid carcinomas, e.g. [[psammoma bodies]], papillae, nuclear changes of [[papillary thyroid carcinoma|PTC]].
+DDx:
+*[[Poorly differentiated carcinoma of the thyroid|Poorly differentiated thyroid carcinoma]].
+*[[Squamous cell carcinoma]].
+*[[Medullary thyroid carcinoma]].
+*[[Sarcoma]].
+===Images===
+<gallery>
+Image:Anaplastic_thyroid_carcinoma_low_mag.jpg | Anaplastic thyroid carcinoma with a component of PTC. (WC)
+</gallery>
+==IHC==
+*Keratin (AE1/AE3) +ve.
+*Vimentin +ve, >90%.<ref name=pmid1712540>{{cite journal |author=Ordóñez NG, El-Naggar AK, Hickey RC, Samaan NA |title=Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases |journal=Am. J. Clin. Pathol. |volume=96 |issue=1 |pages=15–24 |year=1991 |month=July |pmid=1712540 |doi= |url=}}</ref>
+*Thyroglobulin - rarely +ve (~15%).<ref name=pmid1712540/>
+*CEA -ve, calcitonin -ve; to r/o medullary.
+*p53 +ve.
+*[[TTF-1]] +ve.
+==See also==
+*[[Thyroid gland]].
+==References==
+{{Reflist|2}}
 [[Category:Diagnosis]]
+[[Category:Thyroid gland]]