Difference between revisions of "Metaphyseal fibrous defect"
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*[http://pathologyoutlines.com/wick/non-ossifying%20fibroma%20(metaphyseal%20fibrous%20defect)%20micro.jpg] | *[http://pathologyoutlines.com/wick/non-ossifying%20fibroma%20(metaphyseal%20fibrous%20defect)%20micro.jpg] | ||
*[File:Bone Metaphyseal Fibrous Defect Medium Power.JPG|thumb|Bone Metaphyseal Fibrous Defect Medium Power] | |||
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==Stains== | ==Stains== | ||
Revision as of 07:42, 15 October 2014
| Metaphyseal fibrous defect | |
|---|---|
| Diagnosis in short | |
|
| |
| Synonyms | Nonossifying fibroma |
| Clinical history | Incidental radiograhic finding |
| Radiology | Lucent defect |
General
- Common
- Non-neoplastic
- Self-limited
- Skeletally immature individuals, children and adolescent
- Often small lesions discovered as an radiographic incidentaloma
- Rarely seen as a pathologic specimen (should not be biopsied)
Synonyms
- Nonossifying fibroma (larger but otherwise identical)
- Fibrous cortical defect
- Fibrous metaphyseal defect
- Fibroxanthoma of bone
Site
- Metaphysis of distal femur or proximal tibia (80%)
- Cortical
- Metaphysis
- Long bones
- Eccentric location
Gross
Firm, granular, brown to yellow to red
Microscopic
Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent.
Differential Diagnosis
- Giant cell tumour of bone (epiphyseal location, occurs in adults)
Relevant Diagnostic Groups
- Clinical
- Pathologic
- Giant cell lesions of bone.
- Spindle cell lesions of bone.
Images
- [1]
- [2]
- [3]
- [4]
- [File:Bone Metaphyseal Fibrous Defect Medium Power.JPG|thumb|Bone Metaphyseal Fibrous Defect Medium Power]
- [File:Bone Metaphyseal Fibrous Defect High Power.JPG|thumb|Bone Metaphyseal Fibrous Defect High Power]
![[1]](http://njms2.umdnj.edu/tutorweb/casegifs/nofhe1.jpg){kind=link}
![[2]](http://njms2.umdnj.edu/tutorweb/casegifs/nofhe2.jpg){kind=link}
![[4]](http://pathologyoutlines.com/wick/non-ossifying%20fibroma%20(metaphyseal%20fibrous%20defect)%20micro.jpg){kind=link}
Stains
Not relevant.
IHC
Not relevant
Molecular
Not relevant
Syndromes
Jaffe-Campanacci syndrome [3]
Clinical history
- Incidental radiographic finding
- Pathologic fracture
Prognosis
- Ideally should not be biopsied
- Radiographically characteristic and benign
- Ideally should not be treated or even biopsied
- Spontaneously resolve by ossification
- May resolve into a 'bone island'
Radiographic findings
Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone
Sign out
BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.
See also
- http://njms2.umdnj.edu/tutorweb/case8.htm
- http://www.pathologyoutlines.com/topic/bonemetaphysealfibrousdefect.html
- http://radiopaedia.org/articles/fibrous-cortical-defect
- http://radiopaedia.org/articles/non-ossifying-fibroma-1
References
- ↑ URL: http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic. Accessed on: October 14, 2014.
- ↑ URL: http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1. Accessed on: October 14, 2014.
- ↑ URL: http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome. Accessed on: October 14, 2014.