Difference between revisions of "Littoral cell angioma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Littoral_cell_angioma_of_the_spleen_-_low_mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Littoral cell angioma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = anastoming, small vascular channels, cystic spaces - may have papillary projections | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]] | | LMDDx = [[hemangioendothelioma]], [[angiosarcoma]], [[hemangiopericytoma]], [[splenic hamartoma]] | ||
| Line 18: | Line 18: | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = weight loss | ||
| Signs = | | Signs = pyrexia (fever), splenomegaly | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = solitary hypodense lesion | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign | ||
Revision as of 21:24, 16 February 2014
| Littoral cell angioma | |
|---|---|
| Diagnosis in short | |
 Littoral cell angioma. H&E stain. | |
|
| |
| LM | anastoming, small vascular channels, cystic spaces - may have papillary projections |
| LM DDx | hemangioendothelioma, angiosarcoma, hemangiopericytoma, splenic hamartoma |
| Site | spleen |
|
| |
| Clinical history | weight loss |
| Signs | pyrexia (fever), splenomegaly |
| Prevalence | rare |
| Radiology | solitary hypodense lesion |
| Prognosis | benign |
Littoral cell angioma, abbreviated LCA, is an uncommon benign vascular lesion of the spleen.
Angioma, in general, is dealt with in vascular malformations.
General
Features:[1]
- Rare.
- Benign.
- Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.
Note:
Microscopic
Features:[1]
- Anastoming, small vascular channels.
- Cystic spaces.
- May have papillary projections.[2]
DDx:[1]
- Vascular lesions:
Images
LCA - very low mag. (WC)
LCA - low mag. (WC)
LCA - intermed. mag. (WC)
LCA - high mag. (WC)
LCA - very high mag. (WC)
www:
IHC
Features:[1]
- CD68 +ve.
- CD31 +ve
Others:
- CD34 -ve.
- Factor VIII +ve.
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Tan, YM.; Chuah, KL.; Wong, WK. (Jul 2004). "Littoral cell angioma of the spleen.". Ann Acad Med Singapore 33 (4): 524-6. PMID 15329769. http://www.annals.edu.sg/pdf200408/V33N4p524.pdf.
- ↑ 2.0 2.1 Dascalescu, CM.; Wendum, D.; Gorin, NC. (Sep 2001). "Littoral-cell angioma as a cause of splenomegaly.". N Engl J Med 345 (10): 772-3. doi:10.1056/NEJM200109063451016. PMID 11547761. http://www.nejm.org/doi/full/10.1056/NEJM200109063451016.
- ↑ URL: http://www.merriam-webster.com/dictionary/littoral. Accessed on: 24 July 2011.
- ↑ URL: http://dictionary.reference.com/browse/littoral. Accessed on: 24 July 2011.