Difference between revisions of "Carcinoma ex pleomorphic adenoma"
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==General== | ==General== | ||
Definition: | Definition: | ||
* | *Malignancy arising in a ''[[pleomorphic adenoma]]''.<ref name=pmid21744105>{{Cite journal | last1 = Antony | first1 = J. | last2 = Gopalan | first2 = V. | last3 = Smith | first3 = RA. | last4 = Lam | first4 = AK. | title = Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. | journal = Head Neck Pathol | volume = 6 | issue = 1 | pages = 1-9 | month = Mar | year = 2012 | doi = 10.1007/s12105-011-0281-z | PMID = 21744105 }}</ref> | ||
Diagnosis (either 1 or 2): | Diagnosis (either 1 or 2): | ||
| Line 11: | Line 11: | ||
Epidemiology: | Epidemiology: | ||
*Rare. | *Rare. | ||
==Gross== | |||
*Usually mass lesion - partoid gland.<ref name=pmid21744105/> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 17:15, 23 November 2013
Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a rare malignant salivary gland tumour that arise from a pleomorphic adenoma.
General
Definition:
- Malignancy arising in a pleomorphic adenoma.[1]
Diagnosis (either 1 or 2):
- History of a pleomorphic adenoma at the same site.
- Features of a pleomorphic adenoma and a carcinoma.
Epidemiology:
- Rare.
Gross
- Usually mass lesion - partoid gland.[1]
Microscopic
Features:
- Cells with cytologic features of malignancy - key feature.
- Architecture (any of the following):
- Glands.
- Nests.
- Single cells (may be subtle).
Architectural patterns:
- Ductal carcinoma NOS (arising from ductal cells) - most common pattern for Ca ex PA.
- Myoepithelial carcinoma NOS (arising from myoepithelial cells).
- "Named carcinoma":
- Salivary duct carcinoma - second most common pattern for Ca ex PA.
- Mucoepidermoid carcinoma.
- Adenoid cystic carcinoma.
Note:
- Often adenocarcinoma-like.
- Myoepithelial cells may be clear cells.
DDx:
Subclassification
Extent of invasion:[2]
- Non-invasive AKA intracapsular AKA in situ.
- Minimally invasive <=1.5 mm beyond the capsule.
- Widely invasive >1.5 mm beyond the capsule.
See also
References
- ↑ 1.0 1.1 Antony, J.; Gopalan, V.; Smith, RA.; Lam, AK. (Mar 2012). "Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data.". Head Neck Pathol 6 (1): 1-9. doi:10.1007/s12105-011-0281-z. PMID 21744105.
- ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf. Accessed on: 2 April 2012.