Difference between revisions of "Carcinoma ex pleomorphic adenoma"
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'''Carcinoma ex pleomorphic adenoma''', abbreviated ''ca ex PA'', is a rare malignant [[salivary gland]] tumour that arise from a [[pleomorphic | '''Carcinoma ex pleomorphic adenoma''', abbreviated ''ca ex PA'', is a rare malignant [[salivary gland]] tumour that arise from a [[pleomorphic adenoma]]. | ||
==General== | ==General== | ||
| Line 30: | Line 30: | ||
Note: | Note: | ||
*Often adenocarcinoma-like. | *Often adenocarcinoma-like. | ||
*Myoepithelial cells may be clear cells. | *Myoepithelial cells may be clear cells. | ||
===Subclassification=== | ===Subclassification=== | ||
| Line 41: | Line 41: | ||
*[[Salivary gland]]. | *[[Salivary gland]]. | ||
*[[Pleomorphic adenoma]]. | *[[Pleomorphic adenoma]]. | ||
*[[Myoepithelioma]]. | |||
*[[Salivary duct carcinoma]]. | |||
==References== | ==References== | ||
Revision as of 17:09, 23 November 2013
Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a rare malignant salivary gland tumour that arise from a pleomorphic adenoma.
General
Definition:
- Malignant transformation of a pleomorphic adenoma.
Diagnosis (either 1 or 2):
- History of a pleomorphic adenoma at the same site.
- Features of a pleomorphic adenoma and a carcinoma.
Epidemiology:
- Rare.
Microscopic
Features:
- Cells with cytologic features of malignancy.
- Architecture (any of the following):
- Glands.
- Nests.
- Single cells (may be subtle).
Architectural patterns:
- Ductal carcinoma NOS (arising from ductal cells) - most common pattern for Ca ex PA.
- Myoepithelial cacinoma NOS (arising from myoepithelial cells).
- "Named carcinoma":
- Salivary duct carcinoma - second most common pattern for Ca ex PA.
- Mucoepidermoid carcinoma.
- Adenoid cystic carcinoma.
Note:
- Often adenocarcinoma-like.
- Myoepithelial cells may be clear cells.
Subclassification
Extent of invasion:[1]
- Non-invasive AKA intracapsular AKA in situ.
- Minimally invasive <=1.5 mm beyond the capsule.
- Widely invasive >1.5 mm beyond the capsule.
See also
References
- ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf. Accessed on: 2 April 2012.