Uterus - Revision history

Michael: /* BRCA carrier */

2018-06-06T19:33:32Z

BRCA carrier

← Older revision		Revision as of 19:33, 6 June 2018
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	*STIC ~ 6.2%		*STIC ~ 6.2%

			===Grossing===
			*In prophylatic procedures, the ovaries and tubes, endometrium, and lower uterine segment should all be [[submitted in total]].<ref name=pmid24495259>{{Cite journal \| last1 = Downes \| first1 = MR. \| last2 = Allo \| first2 = G. \| last3 = McCluggage \| first3 = WG. \| last4 = Sy \| first4 = K. \| last5 = Ferguson \| first5 = SE. \| last6 = Aronson \| first6 = M. \| last7 = Pollett \| first7 = A. \| last8 = Gallinger \| first8 = S. \| last9 = Bilbily \| first9 = E. \| title = Review of findings in prophylactic gynaecological specimens in Lynch syndrome with literature review and recommendations for grossing. \| journal = Histopathology \| volume = 65 \| issue = 2 \| pages = 228-39 \| month = Aug \| year = 2014 \| doi = 10.1111/his.12386 \| PMID = 24495259 }}</ref>
	===Microscopic===		===Microscopic===

Michael: /* BRCA carrier */

2016-09-06T17:25:11Z

BRCA carrier

← Older revision		Revision as of 17:25, 6 September 2016
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	*Early [[serous carcinoma]] of the fallopian tube or ovary.		*Early [[serous carcinoma]] of the fallopian tube or ovary.
	*[[STIC]].		*[[STIC]].

			===IHC===
			*p53 -ve.
			*p16 -ve.
			*Ki-67 low.

	===Sign out===		===Sign out===

Michael: /* BRCA carrier */

2016-08-26T20:20:21Z

BRCA carrier

← Older revision		Revision as of 20:20, 26 August 2016
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	==BRCA carrier==		==BRCA carrier==
	===General===		===General===
	*Prophylatic bilateral salpingo-oophorectomies (BSOs) done in [[BRCA1\|BRCA carrier]]s to ~~prevent~~ [[serous carcinoma]].		*Prophylatic bilateral salpingo-oophorectomies (BSOs) done in [[BRCA1\|BRCA carrier]]s to reduce risk of [[serous carcinoma]].<ref name=pmid27241111>{{Cite journal \| last1 = Shaw \| first1 = PA. \| last2 = Clarke \| first2 = BA. \| title = Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers. \| journal = Surg Pathol Clin \| volume = 9 \| issue = 2 \| pages = 307-28 \| month = Jun \| year = 2016 \| doi = 10.1016/j.path.2016.02.002 \| PMID = 27241111 }}</ref>

	Incidence of pathology in prophylatic BSOs in a series of 226 cases:<ref name=pmid22710074>{{Cite journal \| last1 = Mingels \| first1 = MJ. \| last2 = Roelofsen \| first2 = T. \| last3 = van der Laak \| first3 = JA. \| last4 = de Hullu \| first4 = JA. \| last5 = van Ham \| first5 = MA. \| last6 = Massuger \| first6 = LF. \| last7 = Bulten \| first7 = J. \| last8 = Bol \| first8 = M. \| title = Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls. \| journal = Gynecol Oncol \| volume = 127 \| issue = 1 \| pages = 88-93 \| month = Oct \| year = 2012 \| doi = 10.1016/j.ygyno.2012.06.015 \| PMID = 22710074 }}</ref>		Incidence of pathology in prophylatic BSOs in a series of 226 cases:<ref name=pmid22710074>{{Cite journal \| last1 = Mingels \| first1 = MJ. \| last2 = Roelofsen \| first2 = T. \| last3 = van der Laak \| first3 = JA. \| last4 = de Hullu \| first4 = JA. \| last5 = van Ham \| first5 = MA. \| last6 = Massuger \| first6 = LF. \| last7 = Bulten \| first7 = J. \| last8 = Bol \| first8 = M. \| title = Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls. \| journal = Gynecol Oncol \| volume = 127 \| issue = 1 \| pages = 88-93 \| month = Oct \| year = 2012 \| doi = 10.1016/j.ygyno.2012.06.015 \| PMID = 22710074 }}</ref>

Michael: /* BRCA carrier */

2016-08-26T20:19:05Z

BRCA carrier

← Older revision		Revision as of 20:19, 26 August 2016
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	==BRCA carrier==		==BRCA carrier==
	===General===		===General===
	*Prophylatic ~~TAH~~-~~BSO~~ done in [[BRCA1\|BRCA carrier]]s ~~- prevents~~ [[serous carcinoma]].		*Prophylatic bilateral salpingo-oophorectomies (BSOs) done in [[BRCA1\|BRCA carrier]]s to prevent [[serous carcinoma]].

	Incidence of pathology in prophylatic BSOs in a series of 226 cases:<ref name=pmid22710074>{{Cite journal \| last1 = Mingels \| first1 = MJ. \| last2 = Roelofsen \| first2 = T. \| last3 = van der Laak \| first3 = JA. \| last4 = de Hullu \| first4 = JA. \| last5 = van Ham \| first5 = MA. \| last6 = Massuger \| first6 = LF. \| last7 = Bulten \| first7 = J. \| last8 = Bol \| first8 = M. \| title = Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls. \| journal = Gynecol Oncol \| volume = 127 \| issue = 1 \| pages = 88-93 \| month = Oct \| year = 2012 \| doi = 10.1016/j.ygyno.2012.06.015 \| PMID = 22710074 }}</ref>		Incidence of pathology in prophylatic BSOs in a series of 226 cases:<ref name=pmid22710074>{{Cite journal \| last1 = Mingels \| first1 = MJ. \| last2 = Roelofsen \| first2 = T. \| last3 = van der Laak \| first3 = JA. \| last4 = de Hullu \| first4 = JA. \| last5 = van Ham \| first5 = MA. \| last6 = Massuger \| first6 = LF. \| last7 = Bulten \| first7 = J. \| last8 = Bol \| first8 = M. \| title = Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls. \| journal = Gynecol Oncol \| volume = 127 \| issue = 1 \| pages = 88-93 \| month = Oct \| year = 2012 \| doi = 10.1016/j.ygyno.2012.06.015 \| PMID = 22710074 }}</ref>

Michael: /* BRCA carrier */

2016-08-26T20:18:10Z

BRCA carrier

← Older revision		Revision as of 20:18, 26 August 2016
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	*Prophylatic TAH-BSO done in [[BRCA1\|BRCA carrier]]s - prevents [[serous carcinoma]].		*Prophylatic TAH-BSO done in [[BRCA1\|BRCA carrier]]s - prevents [[serous carcinoma]].

	Incidence of pathology in prophylatic BSOs - a series of 226 cases:<ref name=pmid22710074>{{Cite journal \| last1 = Mingels \| first1 = MJ. \| last2 = Roelofsen \| first2 = T. \| last3 = van der Laak \| first3 = JA. \| last4 = de Hullu \| first4 = JA. \| last5 = van Ham \| first5 = MA. \| last6 = Massuger \| first6 = LF. \| last7 = Bulten \| first7 = J. \| last8 = Bol \| first8 = M. \| title = Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls. \| journal = Gynecol Oncol \| volume = 127 \| issue = 1 \| pages = 88-93 \| month = Oct \| year = 2012 \| doi = 10.1016/j.ygyno.2012.06.015 \| PMID = 22710074 }}</ref>		Incidence of pathology in prophylatic BSOs in a series of 226 cases:<ref name=pmid22710074>{{Cite journal \| last1 = Mingels \| first1 = MJ. \| last2 = Roelofsen \| first2 = T. \| last3 = van der Laak \| first3 = JA. \| last4 = de Hullu \| first4 = JA. \| last5 = van Ham \| first5 = MA. \| last6 = Massuger \| first6 = LF. \| last7 = Bulten \| first7 = J. \| last8 = Bol \| first8 = M. \| title = Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls. \| journal = Gynecol Oncol \| volume = 127 \| issue = 1 \| pages = 88-93 \| month = Oct \| year = 2012 \| doi = 10.1016/j.ygyno.2012.06.015 \| PMID = 22710074 }}</ref>
	*Invasive carcinoma ~ 0.9%.		*Invasive carcinoma ~ 0.9%.
	*STIC ~ 6.2%		*STIC ~ 6.2%

Michael: /* General */

2016-08-26T20:16:58Z

General

← Older revision		Revision as of 20:16, 26 August 2016
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	===General===		===General===
	*Prophylatic TAH-BSO done in [[BRCA1\|BRCA carrier]]s - prevents [[serous carcinoma]].		*Prophylatic TAH-BSO done in [[BRCA1\|BRCA carrier]]s - prevents [[serous carcinoma]].

			Incidence of pathology in prophylatic BSOs - a series of 226 cases:<ref name=pmid22710074>{{Cite journal \| last1 = Mingels \| first1 = MJ. \| last2 = Roelofsen \| first2 = T. \| last3 = van der Laak \| first3 = JA. \| last4 = de Hullu \| first4 = JA. \| last5 = van Ham \| first5 = MA. \| last6 = Massuger \| first6 = LF. \| last7 = Bulten \| first7 = J. \| last8 = Bol \| first8 = M. \| title = Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls. \| journal = Gynecol Oncol \| volume = 127 \| issue = 1 \| pages = 88-93 \| month = Oct \| year = 2012 \| doi = 10.1016/j.ygyno.2012.06.015 \| PMID = 22710074 }}</ref>
			*Invasive carcinoma ~ 0.9%.
			*STIC ~ 6.2%

	===Microscopic===		===Microscopic===

Michael: /* BRCA carrier */

2016-08-26T20:11:02Z

BRCA carrier

← Older revision		Revision as of 20:11, 26 August 2016
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	===General===		===General===
	*Prophylatic TAH-BSO done in [[BRCA1\|BRCA carrier]]s - prevents [[serous carcinoma]].		*Prophylatic TAH-BSO done in [[BRCA1\|BRCA carrier]]s - prevents [[serous carcinoma]].

			===Microscopic===

			DDx:
			*Early [[serous carcinoma]] of the fallopian tube or ovary.
			*[[STIC]].

	===Sign out===		===Sign out===

Michael: /* Dysfunctional uterine bleeding */

2016-08-26T20:10:16Z

Dysfunctional uterine bleeding

← Older revision		Revision as of 20:10, 26 August 2016
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	- BILATERAL UTERINE TUBES WITHOUT SIGNIFICANT PATHOLOGY.		- BILATERAL UTERINE TUBES WITHOUT SIGNIFICANT PATHOLOGY.
	- NEGATIVE FOR MALIGNANCY.		- NEGATIVE FOR MALIGNANCY.
			</pre>

			==BRCA carrier==
			===General===
			*Prophylatic TAH-BSO done in [[BRCA1\|BRCA carrier]]s - prevents [[serous carcinoma]].

			===Sign out===
			<pre>
			Uterus, Cervix, Fallopian Tubes and Ovaries, Total Abdominal Hysterectomy and Bilateral Salpingo-Oophorectomy:
			- Uterus with fibrous serosal adhesions.
			- Cervix within normal limits.
			- Atherosclerosis, moderate.
			- Inactive endometrium with cystic changes.
			- Uterine adenomyosis.
			- Fallopian tubes within normal limits.
			- Ovaries with benign cysts.
			- NEGATIVE for malignancy.
	</pre>		</pre>

Michael: /* Uterine prolapse */

2016-05-16T15:07:22Z

Uterine prolapse

← Older revision		Revision as of 15:07, 16 May 2016
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	==Uterine prolapse==		==Uterine prolapse==
	:''Urogenital prolapse'' redirects here.		:''Urogenital prolapse'' redirects here.
	~~===General===~~		{{main\|Uterine prolapse}}
	*'''[[Clinical diagnosis]]'''.
	*A common indication for a total hysterectomy.
	*Hysterectomy specimen usually comes with some [[vagina]]l mucosa.
	*Parous women, usually menopausal.<ref name=pmid20607975>{{~~Cite journal~~ \| ~~last1 = Mladenović-Segedi \| first1 = L. \| last2 = Segedi \| first2 = D. \| title = [Most important etiologic factors in the development of genital~~ prolapse~~]. \| journal = Srp Arh Celok Lek \| volume = 138 \| issue = 5-6 \| pages = 315-8 \| month = \| year = \| doi = \| PMID = 20607975 }}</ref>~~
	*Possibly [[obesity]] - studies vary.<ref name=pmid22732579 >{{Cite journal \| last1 = Thubert \| first1 = T. \| last2 = Deffieux \| first2 = X. \| last3 = Letouzey \| first3 = V. \| last4 = Hermieu \| first4 = JF. \| title = [Obesity and urogynecology: a systematic review]. \| journal = Prog Urol \| volume = 22 \| issue = 8 \| pages = 445-53 \| month = Jul \| year = 2012 \| doi = 10.1016/j.purol.2012.03.009 \| PMID = 22732579 }}</ref>

	~~===Gross===~~
	*Long cervix.

	~~===Microscopic===~~
	~~Features:~~
	*Uterus: non-specific.
	*Vaginal mucosa: (focal) keratinization due to rubbing - '''common finding'''.

	~~Note:~~
	*Benign stromal atypia may be seen.<ref name=pmid10680891>{{Cite journal \| last1 = Nucci \| first1 = MR. \| last2 = Young \| first2 = RH. \| last3 = Fletcher \| first3 = CD. \| title = Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 2 \| pages = 231-40 \| month = Feb \| year = 2000 \| doi = \| PMID = 10680891 }}~~</ref><ref>{{Cite journal \| last1 = Rodrigues \| first1 = MI ''et al.'' \| last2 = \| first2 = \| title = Atypical stromal cells as a diagnostic pitfall in lesions of the lower~~
	female genital tract and uterus: a review and presentation of some unusual cases \| journal = Patología \| volume = 47 \| issue = 2 \| pages = 103-7 \| month = April-June \| year = 2009 \| doi = \| PMID = \| PMC = \| url = http://www.medigraphic.com/pdfs/patrevlat/rlp-2009/rlp092e.pdf }}</ref>

	~~====Images====~~
	~~<gallery>~~
	~~Image: Keratinized cervix -- intermed mag.jpg \| Keratinized cervix - intermed. mag. (WC)~~
	~~Image: Keratinized cervix -- high mag.jpg \| Keratinized cervix - high mag. (WC)~~
	~~Image: Keratinized cervix -- very high mag.jpg \| Keratinized cervix - very high mag. (WC)~~
	~~</gallery>~~

	~~===Sign out===~~
	~~<pre>~~
	~~UTERUS AND CERVIX, TOTAL HYSTERECTOMY:~~
	~~- UTERINE CERVIX WITH FOCAL KERATINIZATION OTHERWISE WITHIN NORMAL LIMITS.~~
	~~- NONPROLIFERATIVE ENDOMETRIUM.~~
	~~</pre>~~

	~~<pre>~~
	~~UTERUS AND CERVIX, TOTAL HYSTERECTOMY:~~
	~~- UTERINE CERVIX WITH KERATINIZATION, OTHERWISE WITHIN NORMAL LIMITS.~~
	~~- CYSTIC NONPROLIFERATIVE ENDOMETRIUM.~~
	~~- UTERINE SMOOTH MUSCLE AND SEROSA WITHIN NORMAL LIMITS.~~
	~~- NEGATIVE FOR MALIGNANCY.~~
	~~</pre>~~

	~~====Denudated exocervix====~~
	~~<pre>~~
	~~UTERUS AND CERVIX, TOTAL HYSTERECTOMY:~~
	~~- UTERINE CERVIX WITH MILD CHRONIC INFLAMMATION AND EXOCERVICAL DENUDATION,~~
	~~NO EVIDENCE OF DYSPLASIA.~~
	~~- CYSTIC NONPROLIFERATIVE ENDOMETRIUM.~~
	~~- UTERINE CORPUS WITH BENIGN HYALINIZED NODULE.~~
	~~- NEGATIVE FOR MALIGNANCY.~~

	~~COMMENT:~~
	~~Levels were cut on the uterine cervix sections (A1 and A2).~~
	~~</pre>~~

	~~====Focal ulceration====~~
	~~<pre>~~
	~~- UTERINE CERVIX WITH PARAKERATOSIS, ACANTHOSIS, CHRONIC INFLAMMATION, AND FOCAL~~
	~~ULCERATION ASSOCIATED WITH GRANULATION TISSUE FORMATION.~~
	~~- PARTIALLY CYSTIC NONPROLIFERATIVE ENDOMETRIUM.~~
	~~- UTERINE CORPUS WITH LEIOMYOMA.~~
	~~- NO EVIDENCE OF DYSPLASIA.~~
	~~- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.~~
	~~</pre>~~

	~~====With endometrial polyp====~~
	~~<pre>~~
	~~UTERUS AND CERVIX, TOTAL HYSTERECTOMY:~~
	~~- BENIGN ENDOMETRIAL POLYP WITH NONPROLIFERATIVE ENDOMETRIAL GLANDS.~~
	~~- UTERINE CERVIX WITH MILD CHRONIC INFLAMMATION AND FOCAL EXOCERVICAL DENUDATION,~~
	~~NO EVIDENCE OF DYSPLASIA.~~
	~~- VERY WEAKLY PROLIFERATIVE ENDOMETRIUM, MOSTLY ATROPHIC APPEARING, NEGATIVE FOR~~
	~~ENDOMETRIAL HYPERPLASIA.~~
	~~- UTERINE CORPUS WITHIN NORMAL LIMITS.~~
	~~- NEGATIVE FOR MALIGNANCY.~~
	~~</pre>~~

	==Dysfunctional uterine bleeding==		==Dysfunctional uterine bleeding==

Michael: /* Microscopic */

2016-05-16T15:05:48Z

Microscopic

← Older revision		Revision as of 15:05, 16 May 2016
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	Note:		Note:
	*Benign stromal atypia may be seen.<ref name=pmid10680891>{{Cite journal \| last1 = Nucci \| first1 = MR. \| last2 = Young \| first2 = RH. \| last3 = Fletcher \| first3 = CD. \| title = Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 2 \| pages = 231-40 \| month = Feb \| year = 2000 \| doi = \| PMID = 10680891 }}</ref><ref>{{Cite journal \| last1 = Rodrigues \| first1 = MI ~~\| last2 =~~ ''et al.'' \| first2 = \| title = Atypical stromal cells as a diagnostic pitfall in lesions of the lower		*Benign stromal atypia may be seen.<ref name=pmid10680891>{{Cite journal \| last1 = Nucci \| first1 = MR. \| last2 = Young \| first2 = RH. \| last3 = Fletcher \| first3 = CD. \| title = Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 2 \| pages = 231-40 \| month = Feb \| year = 2000 \| doi = \| PMID = 10680891 }}</ref><ref>{{Cite journal \| last1 = Rodrigues \| first1 = MI ''et al.'' \| last2 = \| first2 = \| title = Atypical stromal cells as a diagnostic pitfall in lesions of the lower
	female genital tract and uterus: a review and presentation of some unusual cases \| journal = Patología \| volume = 47 \| issue = 2 \| pages = 103-7 \| month = April-June \| year = 2009 \| doi = \| PMID = \| PMC = \| url = http://www.medigraphic.com/pdfs/patrevlat/rlp-2009/rlp092e.pdf }}</ref>		female genital tract and uterus: a review and presentation of some unusual cases \| journal = Patología \| volume = 47 \| issue = 2 \| pages = 103-7 \| month = April-June \| year = 2009 \| doi = \| PMID = \| PMC = \| url = http://www.medigraphic.com/pdfs/patrevlat/rlp-2009/rlp092e.pdf }}</ref>