Talk:Neuropathology tumours - Revision history

Michael: /* Pilocytic astrocytoma */ new section

2010-12-21T19:57:30Z

Pilocytic astrocytoma: new section

← Older revision		Revision as of 19:57, 21 December 2010
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	CLIVUS:		CLIVUS:
	<br>- CHORDOMA.		<br>- CHORDOMA.

			== Pilocytic astrocytoma ==

			===Microscopic description===
			The smear shows bipolar cells with thick hair-like processes. The sections show a cellular tumour with eosinophilic cytoplasm drawn into processes. Eosinophilic granular bodies and Rosenthal fibres are present, as demonstrated with trichrome staining.

			There is no nuclear pleomorphism and no mitotic activity. There is no microvascular proliferation and no necrosis.

			===Final diagnosis===
			BRAIN:<br>
			- PILOCYTIC ASTROCYTOMA (WHO GRADE I).

Michael: /* Chordoma */ new section

2010-12-20T16:31:35Z

Chordoma: new section

← Older revision		Revision as of 16:31, 20 December 2010
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	NERVE, LEFT RADIAL:		NERVE, LEFT RADIAL:
	<Br>- TRAUMATIC NEUROMA.		<Br>- TRAUMATIC NEUROMA.

			== Chordoma ==

			===Microscopic description===
			The sections show a tumour composed of irregular anatoming cords of physaliferous cells resting on a myxoid background. Mitotic activity is not detected.

			Immunostains demonstrate that the tumour cells intensely express cytoplasmic for low molecular weight keratin (LMWCK) and membranous epithelial membrane antigen (EMA). There is weak, focal cytoplasmic expression of S100.

			===Final diagnosis===
			CLIVUS:
			<br>- CHORDOMA.

Michael: /* Hemangioblastoma */

2010-12-09T21:00:21Z

Hemangioblastoma

← Older revision		Revision as of 21:00, 9 December 2010
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	===Final diagnosis===		===Final diagnosis===
	BRAIN, CEREBELLUM, EXCISION:		BRAIN, CEREBELLUM, EXCISION:
	<br> - HEMANGIOBLASTOMA.		<br> - HEMANGIOBLASTOMA (WHO GRADE I).

	==Metastatic large cell carcinoma==		==Metastatic large cell carcinoma==

Michael: /* Hemangioblastoma */ modify

2010-12-09T20:58:05Z

Hemangioblastoma: modify

← Older revision		Revision as of 20:58, 9 December 2010
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	The sections show a partially cystic vascular tumour with histomorphological normal endothelial cells and vacuolated polygonal cells with hyperchromatic nuclei. There is no mitotic activity. The tumour has a poorly demarcated border. Cerebellum adjacent to the tumour demonstrates Purkinje cell loss and Bergmann gliosis.		The sections show a partially cystic vascular tumour with histomorphological normal endothelial cells and vacuolated polygonal cells with hyperchromatic nuclei. There is no mitotic activity. The tumour has a poorly demarcated border. Cerebellum adjacent to the tumour demonstrates Purkinje cell loss and Bergmann gliosis.

	~~Immunohistochemical~~ staining ~~shows that the tumour is positive focally and weakly for~~ inhibin and ~~is strongly positive for~~ neuron-specific enolase (NSE).		The large polygonal cells have cytoplasmic staining with alpha-inhibin and neuron-specific enolase (NSE). The tumour does not stain for EMA.


	===Final diagnosis===		===Final diagnosis===
	BRAIN, CEREBELLUM, EXCISION:		BRAIN, CEREBELLUM, EXCISION:
	<br> - HEMANGIOBLASTOMA.		<br> - HEMANGIOBLASTOMA.


	==Metastatic large cell carcinoma==		==Metastatic large cell carcinoma==

Michael: /* Neuroma */ new section

2010-11-19T22:01:09Z

Neuroma: new section

← Older revision		Revision as of 22:01, 19 November 2010
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	BRAIN, CEREBELLUM:		BRAIN, CEREBELLUM:
	<br>-METASTATIC LARGE CELL ADENOCARCINOMA.		<br>-METASTATIC LARGE CELL ADENOCARCINOMA.

			== Neuroma ==

			===Microscopic===
			The section shows a medium-sized nerve with adjacent small organized micro-fascicles in collagen, consistent with nerve regeneration following injury.

			===Diagnosis===
			NERVE, LEFT RADIAL:
			<Br>- TRAUMATIC NEUROMA.

Michael: /* Meningioma */ redirect

2010-11-17T14:20:41Z

Meningioma: redirect

← Older revision		Revision as of 14:20, 17 November 2010
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	==Meningioma==		==Meningioma==
	~~===Microscopic===~~		See: ''[[Talk:Meningioma]]''.
	~~The~~ '''~~sections shows~~'~~'' a moderately cellular lesion with prominent whorls, thick-walled blood vessels and psammomatous calcifications.~~

	There are no macronucleoli, there is no sheeting architecture, no hypercellularity, and no spontaneous necrosis. The cells of the lesion do not have small cell change. There is no mitotic activity. '''There is no brain invasion./No brain tissue is present.'''

	~~Immunohistochemical staining of the tumour shows nuclear PR positivity. The Ki-67 does not stain any tumour cells.~~

	~~The tumour cells have occasional nuclear inclusions.~~

	~~===Final diagnosis===~~
	~~MENINGIOMA, GRADE 1~~.

	==Anaplastic astrocytoma==		==Anaplastic astrocytoma==

Michael: /* Microscopic */

2010-11-15T16:20:38Z

Microscopic

← Older revision		Revision as of 16:20, 15 November 2010
Line 12:		Line 12:

	There are no macronucleoli, there is no sheeting architecture, no hypercellularity, and no spontaneous necrosis. The cells of the lesion do not have small cell change. There is no mitotic activity. '''There is no brain invasion./No brain tissue is present.'''		There are no macronucleoli, there is no sheeting architecture, no hypercellularity, and no spontaneous necrosis. The cells of the lesion do not have small cell change. There is no mitotic activity. '''There is no brain invasion./No brain tissue is present.'''

			Immunohistochemical staining of the tumour shows nuclear PR positivity. The Ki-67 does not stain any tumour cells.

	The tumour cells have occasional nuclear inclusions.		The tumour cells have occasional nuclear inclusions.

Michael: /* Meningioma */

2010-11-15T16:19:25Z

Meningioma

← Older revision		Revision as of 16:19, 15 November 2010
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	==Meningioma==		==Meningioma==
	===Microscopic===		===Microscopic===
	The ~~microscopic~~ '''~~section/~~sections~~''' show'''s~~''' a moderately cellular lesion with prominent whorls, thick-walled blood vessels and ~~focal~~ psammomatous calcifications.		The '''sections shows''' a moderately cellular lesion with prominent whorls, thick-walled blood vessels and psammomatous calcifications.

	~~There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2.~~ There are no macronucleoli, no sheeting architecture, no hypercellularity~~, no lymphocyte-like change~~, and no spontaneous necrosis. No brain tissue is present.		There are no macronucleoli, there is no sheeting architecture, no hypercellularity, and no spontaneous necrosis. The cells of the lesion do not have small cell change. There is no mitotic activity. '''There is no brain invasion./No brain tissue is present.'''

			The tumour cells have occasional nuclear inclusions.

	===Final diagnosis===		===Final diagnosis===

Michael: /* Microscopic */

2010-11-15T14:52:04Z

Microscopic

← Older revision		Revision as of 14:52, 15 November 2010
Line 9:		Line 9:
	==Meningioma==		==Meningioma==
	===Microscopic===		===Microscopic===
	The microscopic '''section/sections''' show'''s''' a moderately cellular ~~with~~ lesion with prominent whorls, thick-walled blood vessels and focal psammomatous calcifications.		The microscopic '''section/sections''' show'''s''' a moderately cellular lesion with prominent whorls, thick-walled blood vessels and focal psammomatous calcifications.

	There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2. There are no macronucleoli, no sheeting architecture, no hypercellularity, no lymphocyte-like change, and no spontaneous necrosis. No brain tissue is present.		There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2. There are no macronucleoli, no sheeting architecture, no hypercellularity, no lymphocyte-like change, and no spontaneous necrosis. No brain tissue is present.

	===Final diagnosis===		===Final diagnosis===

Michael: /* Meningioma */

2010-11-15T14:45:17Z

Meningioma

← Older revision		Revision as of 14:45, 15 November 2010
Line 9:		Line 9:
	==Meningioma==		==Meningioma==
	===Microscopic===		===Microscopic===
	The microscopic '''section/sections''' ~~shows~~ a moderately cellular with lesion with prominent whorls, thick-walled blood vessels and focal calcifications.		The microscopic '''section/sections''' show'''s''' a moderately cellular with lesion with prominent whorls, thick-walled blood vessels and focal psammomatous calcifications.

	There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2. There are no macronucleoli, no sheeting architecture, no hypercellularity, and no spontaneous necrosis. ~~The cells of the lesion do not have a high nuclear-to-cytoplasmic ratio~~.		There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2. There are no macronucleoli, no sheeting architecture, no hypercellularity, no lymphocyte-like change, and no spontaneous necrosis. No brain tissue is present.

	===Final diagnosis===		===Final diagnosis===