Talk:Neuropathology - Revision history

Michael: /* Reactive gliosis */

2010-11-30T15:06:17Z

Reactive gliosis

← Older revision		Revision as of 15:06, 30 November 2010
Line 19:		Line 19:

	===Microscopic===		===Microscopic===
	The section shows white matter and grey matter with regions of increased cellularity, consisting predominantly of regularly-spaced (glial) cells with bland-appearing, uniform, non-~~oviod~~ nuclei. Glial cells, focally, have fine, eosinophilic, branching processes. A small subset of cells have moderate nuclear enlargement.		The section shows white matter and grey matter with regions of increased cellularity, consisting predominantly of regularly-spaced (glial) cells with bland-appearing, uniform, non-ovoid nuclei. Glial cells, focally, have fine, eosinophilic, branching processes. A small subset of cells have moderate nuclear enlargement.

	Numerous axonal swellings are noted. There is no mitotic activity and no necrosis. No calcifications are identified.		Numerous axonal swellings are noted. There is no mitotic activity and no necrosis. No calcifications are identified.

Michael: +cav mal

2010-11-19T21:19:46Z

+cav mal

← Older revision		Revision as of 21:19, 19 November 2010
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	BRAIN:		BRAIN:
	<br>-REACTIVE GLIOSIS.		<br>-REACTIVE GLIOSIS.

			==Cavernous malformation==
			===Microscopic===
			The section shows medium-sized back-to-back blood vessels surrounded by hypercellular white matter without nuclear atypia (gliosis).

			There is extensive hemosiderin deposition, focal calcifications, and focal axonal swelling, consistent with prior bleeding and focal tissue compression.

			===Diagnosis===
			BRAIN:
			-CAVERNOUS MALFORMATION.

Michael: /* Reactive gliosis */ fix spelling

2010-11-19T14:35:02Z

Reactive gliosis: fix spelling

← Older revision		Revision as of 14:35, 19 November 2010
Line 19:		Line 19:

	===Microscopic===		===Microscopic===
	The section shows white matter and grey matter with regions of increased cellularity, consisting predominantly of ~~regularily~~-spaced (glial) cells with bland-appearing, uniform, non-oviod nuclei. Glial cells, focally, have fine, eosinophilic, branching processes. A small subset of cells have moderate nuclear enlargement.		The section shows white matter and grey matter with regions of increased cellularity, consisting predominantly of regularly-spaced (glial) cells with bland-appearing, uniform, non-oviod nuclei. Glial cells, focally, have fine, eosinophilic, branching processes. A small subset of cells have moderate nuclear enlargement.

	Numerous axonal swellings are noted. There is no mitotic activity and no necrosis. No calcifications are identified.		Numerous axonal swellings are noted. There is no mitotic activity and no necrosis. No calcifications are identified.

Michael: /* Reactive gliosis */ new section

2010-11-19T14:34:20Z

Reactive gliosis: new section

← Older revision		Revision as of 14:34, 19 November 2010
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	SKIN, BIOPSY:		SKIN, BIOPSY:
	<br>- ABSENCE OF NOTCH-3 IMMUNOSTAINING.		<br>- ABSENCE OF NOTCH-3 IMMUNOSTAINING.

			== Reactive gliosis ==

			===Microscopic===
			The section shows white matter and grey matter with regions of increased cellularity, consisting predominantly of regularily-spaced (glial) cells with bland-appearing, uniform, non-oviod nuclei. Glial cells, focally, have fine, eosinophilic, branching processes. A small subset of cells have moderate nuclear enlargement.

			Numerous axonal swellings are noted. There is no mitotic activity and no necrosis. No calcifications are identified.

			===Diagnosis===
			BRAIN:
			<br>-REACTIVE GLIOSIS.

Michael: /* CADASIL */ update

2010-11-17T14:28:25Z

CADASIL: update

← Older revision		Revision as of 14:28, 17 November 2010
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	==CADASIL==		==CADASIL==
	===Microscopic===		===Microscopic===
	The ~~section shows normal skin with numerous small blood vessels~~. ~~The blood vessels do NOT stain with the~~ Notch-3 ~~immunostain~~. ~~The Notch-3~~ control ~~has the usual staining~~.		The biopsy, containing epidermis, dermis and subcutaneous tissue, is technically satisfactory. Immunostains utilizing a monoclonal antibody 1E4 (anti-Notch-3) at dilution 1:50 shows the absence of granular deposits in the walls of small arteries and veins in the dermis and subcutaneous tissue. Immunostains are strongly positive on positive control tissue from a patient known to have CADASIL.

	===Final diagnosis===		===Final diagnosis===
	SKIN, BIOPSY:		SKIN, BIOPSY:
	<br> - ~~NO PATHOLOGIC DIAGNOSIS~~.		<br>- ABSENCE OF NOTCH-3 IMMUNOSTAINING.

Michael: tweak

2010-11-15T15:10:01Z

tweak

← Older revision		Revision as of 15:10, 15 November 2010
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	==CADASIL==		==CADASIL==
	===Microscopic===		===Microscopic===
	The section shows normal skin with numerous small blood vessels. The blood vessels do NOT stain ~~for NOTCH~~-3. The ~~NOTCH~~-3 control has the usual staining.		The section shows normal skin with numerous small blood vessels. The blood vessels do NOT stain with the Notch-3 immunostain. The Notch-3 control has the usual staining.
	===Final diagnosis===		===Final diagnosis===
	SKIN, BIOPSY:		SKIN, BIOPSY:
	<br> - NO PATHOLOGIC DIAGNOSIS.		<br> - NO PATHOLOGIC DIAGNOSIS.

Michael: +Neg. CADASIL

2010-11-15T15:08:09Z

+Neg. CADASIL

← Older revision		Revision as of 15:08, 15 November 2010
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	<br> - ARTERIOVENOUS MALFORMATION.		<br> - ARTERIOVENOUS MALFORMATION.
	<br> - NEGATIVE FOR MALIGNANCY.		<br> - NEGATIVE FOR MALIGNANCY.

			==CADASIL==
			===Microscopic===
			The section shows normal skin with numerous small blood vessels. The blood vessels do NOT stain for NOTCH-3. The NOTCH-3 control has the usual staining.
			===Final diagnosis===
			SKIN, BIOPSY:
			<br> - NO PATHOLOGIC DIAGNOSIS.

Michael: +AVM

2010-11-11T13:03:52Z

+AVM

New page

==AVM==
===Microscopic===
The section shows numerous large veins that have thickened walls and arteries with intervening brain parenchyma. There is a small focus of monocytoid cells, hemosiderin-laden macrophages and necrosis consistent with prior bleeding.

===Diagnosis===
BRAIN, RIGHT TEMPORAL:
<br> - ARTERIOVENOUS MALFORMATION.
<br> - NEGATIVE FOR MALIGNANCY.