Succinate dehydrogenase - Revision history

Michael: /* See also */

2016-03-15T15:18:24Z

Michael: /* Associated pathology */

2016-03-15T15:17:53Z

Associated pathology

← Older revision		Revision as of 15:17, 15 March 2016
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	*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal \| last1 = Ricketts \| first1 = CJ. \| last2 = Shuch \| first2 = B. \| last3 = Vocke \| first3 = CD. \| last4 = Metwalli \| first4 = AR. \| last5 = Bratslavsky \| first5 = G. \| last6 = Middelton \| first6 = L. \| last7 = Yang \| first7 = Y. \| last8 = Wei \| first8 = MH. \| last9 = Pautler \| first9 = SE. \| title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. \| journal = J Urol \| volume = 188 \| issue = 6 \| pages = 2063-71 \| month = Dec \| year = 2012 \| doi = 10.1016/j.juro.2012.08.030 \| PMID = 23083876 }}</ref>		*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal \| last1 = Ricketts \| first1 = CJ. \| last2 = Shuch \| first2 = B. \| last3 = Vocke \| first3 = CD. \| last4 = Metwalli \| first4 = AR. \| last5 = Bratslavsky \| first5 = G. \| last6 = Middelton \| first6 = L. \| last7 = Yang \| first7 = Y. \| last8 = Wei \| first8 = MH. \| last9 = Pautler \| first9 = SE. \| title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. \| journal = J Urol \| volume = 188 \| issue = 6 \| pages = 2063-71 \| month = Dec \| year = 2012 \| doi = 10.1016/j.juro.2012.08.030 \| PMID = 23083876 }}</ref>
	*[[Gastrointestinal stromal tumour]].		*[[Gastrointestinal stromal tumour]].
	**SDHA mutations = good outcome.<ref name=pmid25188872>{{Cite journal \| last1 = Pantaleo \| first1 = MA. \| last2 = Lolli \| first2 = C. \| last3 = Nannini \| first3 = M. \| last4 = Astolfi \| first4 = A. \| last5 = Indio \| first5 = V. \| last6 = Saponara \| first6 = M. \| last7 = Urbini \| first7 = M. \| last8 = La Rovere \| first8 = S. \| last9 = Gill \| first9 = A. \| title = Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations. \| journal = Genet Med \| volume = \| issue = \| pages = \| month = Sep \| year = 2014 \| doi = 10.1038/gim.2014.115 \| PMID = 25188872 }}</ref>

	==See also==		==See also==

Michael: /* References */

2014-10-27T16:29:42Z

References

← Older revision		Revision as of 16:29, 27 October 2014
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	[[Category:Immunohistochemistry]]		[[Category:Immunohistochemistry]]
			[[Category:Molecular pathology]]

Michael: /* Associated pathology */

2014-10-27T05:57:49Z

Associated pathology

← Older revision		Revision as of 05:57, 27 October 2014
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	*[[Pheochromocytoma]].<ref name=pmid24500761/>		*[[Pheochromocytoma]].<ref name=pmid24500761/>
	*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal \| last1 = Ricketts \| first1 = CJ. \| last2 = Shuch \| first2 = B. \| last3 = Vocke \| first3 = CD. \| last4 = Metwalli \| first4 = AR. \| last5 = Bratslavsky \| first5 = G. \| last6 = Middelton \| first6 = L. \| last7 = Yang \| first7 = Y. \| last8 = Wei \| first8 = MH. \| last9 = Pautler \| first9 = SE. \| title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. \| journal = J Urol \| volume = 188 \| issue = 6 \| pages = 2063-71 \| month = Dec \| year = 2012 \| doi = 10.1016/j.juro.2012.08.030 \| PMID = 23083876 }}</ref>		*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal \| last1 = Ricketts \| first1 = CJ. \| last2 = Shuch \| first2 = B. \| last3 = Vocke \| first3 = CD. \| last4 = Metwalli \| first4 = AR. \| last5 = Bratslavsky \| first5 = G. \| last6 = Middelton \| first6 = L. \| last7 = Yang \| first7 = Y. \| last8 = Wei \| first8 = MH. \| last9 = Pautler \| first9 = SE. \| title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. \| journal = J Urol \| volume = 188 \| issue = 6 \| pages = 2063-71 \| month = Dec \| year = 2012 \| doi = 10.1016/j.juro.2012.08.030 \| PMID = 23083876 }}</ref>
			*[[Gastrointestinal stromal tumour]].
			**SDHA mutations = good outcome.<ref name=pmid25188872>{{Cite journal \| last1 = Pantaleo \| first1 = MA. \| last2 = Lolli \| first2 = C. \| last3 = Nannini \| first3 = M. \| last4 = Astolfi \| first4 = A. \| last5 = Indio \| first5 = V. \| last6 = Saponara \| first6 = M. \| last7 = Urbini \| first7 = M. \| last8 = La Rovere \| first8 = S. \| last9 = Gill \| first9 = A. \| title = Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations. \| journal = Genet Med \| volume = \| issue = \| pages = \| month = Sep \| year = 2014 \| doi = 10.1038/gim.2014.115 \| PMID = 25188872 }}</ref>

	==See also==		==See also==

Michael at 05:54, 27 October 2014

2014-10-27T05:54:54Z

← Older revision		Revision as of 05:54, 27 October 2014
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	'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.		'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.

	~~Mutation-~~associated with ~~pathology~~:		==Immunostain==
			*It is used to look for mitochondrial disease.
			*Loss of staining is pathologic.

			==Associated pathology==
			Mutations in SDH genes are associated with:
	*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal \| last1 = Vicha \| first1 = A. \| last2 = Taieb \| first2 = D. \| last3 = Pacak \| first3 = K. \| title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. \| journal = Endocr Relat Cancer \| volume = 21 \| issue = 3 \| pages = R261-77 \| month = Jun \| year = 2014 \| doi = 10.1530/ERC-13-0398 \| PMID = 24500761 }}</ref>		*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal \| last1 = Vicha \| first1 = A. \| last2 = Taieb \| first2 = D. \| last3 = Pacak \| first3 = K. \| title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. \| journal = Endocr Relat Cancer \| volume = 21 \| issue = 3 \| pages = R261-77 \| month = Jun \| year = 2014 \| doi = 10.1530/ERC-13-0398 \| PMID = 24500761 }}</ref>
	*[[Pheochromocytoma]].<ref name=pmid24500761/>		*[[Pheochromocytoma]].<ref name=pmid24500761/>

Michael at 05:53, 27 October 2014

2014-10-27T05:53:51Z

← Older revision		Revision as of 05:53, 27 October 2014
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	[[Image:Denervation atrophy - sdh - very high mag.jpg\|thumb\|right\|SDH immunostain in a muscle biopsy with [[denervation atrophy]].]]		[[Image:Denervation atrophy - sdh - very high mag.jpg\|thumb\|right\|SDH immunostain in a muscle biopsy with denervation atrophy.]]
	'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.		'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.

Michael at 05:52, 27 October 2014

2014-10-27T05:52:17Z

← Older revision		Revision as of 05:52, 27 October 2014
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			[[Image:Denervation atrophy - sdh - very high mag.jpg\|thumb\|right\|SDH immunostain in a muscle biopsy with [[denervation atrophy]].]]
	'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.		'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.

Michael at 05:50, 27 October 2014

2014-10-27T05:50:06Z

← Older revision		Revision as of 05:50, 27 October 2014
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	*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal \| last1 = Vicha \| first1 = A. \| last2 = Taieb \| first2 = D. \| last3 = Pacak \| first3 = K. \| title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. \| journal = Endocr Relat Cancer \| volume = 21 \| issue = 3 \| pages = R261-77 \| month = Jun \| year = 2014 \| doi = 10.1530/ERC-13-0398 \| PMID = 24500761 }}</ref>		*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal \| last1 = Vicha \| first1 = A. \| last2 = Taieb \| first2 = D. \| last3 = Pacak \| first3 = K. \| title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. \| journal = Endocr Relat Cancer \| volume = 21 \| issue = 3 \| pages = R261-77 \| month = Jun \| year = 2014 \| doi = 10.1530/ERC-13-0398 \| PMID = 24500761 }}</ref>
	*[[Pheochromocytoma]].<ref name=pmid24500761/>		*[[Pheochromocytoma]].<ref name=pmid24500761/>
	*[[Succinate dehydrogenase renal cell carcinoma]].		*[[Succinate dehydrogenase renal cell carcinoma]].<ref name=pmid23083876>{{Cite journal \| last1 = Ricketts \| first1 = CJ. \| last2 = Shuch \| first2 = B. \| last3 = Vocke \| first3 = CD. \| last4 = Metwalli \| first4 = AR. \| last5 = Bratslavsky \| first5 = G. \| last6 = Middelton \| first6 = L. \| last7 = Yang \| first7 = Y. \| last8 = Wei \| first8 = MH. \| last9 = Pautler \| first9 = SE. \| title = Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. \| journal = J Urol \| volume = 188 \| issue = 6 \| pages = 2063-71 \| month = Dec \| year = 2012 \| doi = 10.1016/j.juro.2012.08.030 \| PMID = 23083876 }}</ref>

	==See also==		==See also==

Michael: create

2014-10-27T05:49:18Z

create

New page

'''Succinate dehydrogenase''', abbreviated '''SDH''', is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.

Mutation-associated with pathology:
*[[Paraganglioma]].<ref name=pmid24500761>{{Cite journal | last1 = Vicha | first1 = A. | last2 = Taieb | first2 = D. | last3 = Pacak | first3 = K. | title = Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma. | journal = Endocr Relat Cancer | volume = 21 | issue = 3 | pages = R261-77 | month = Jun | year = 2014 | doi = 10.1530/ERC-13-0398 | PMID = 24500761 }}</ref>
*[[Pheochromocytoma]].<ref name=pmid24500761/>
*[[Succinate dehydrogenase renal cell carcinoma]].

==See also==
*[[Immunohistochemistry]].
*[[Neuromuscular pathology]].

==References==
{{Reflist|1}}

[[Category:Immunohistochemistry]]

← Older revision		Revision as of 15:18, 15 March 2016
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	*[[Immunohistochemistry]].		*[[Immunohistochemistry]].
	*[[Neuromuscular pathology]].		*[[Neuromuscular pathology]].
			*[[Carney-Stratakis syndrome]].

	==References==		==References==