SMARCB1 - Revision history

Michael at 00:57, 27 December 2023

2023-12-27T00:57:27Z

← Older revision		Revision as of 00:57, 27 December 2023
Line 32:		Line 32:
	==See also==		==See also==
	*[[Immunohistochemistry]].		*[[Immunohistochemistry]].
			*[[SMARCA4]].
	*[[SMARCA4-deficient adenocarcinoma of the lung]].		*[[SMARCA4-deficient adenocarcinoma of the lung]].

Michael at 10:30, 13 September 2023

2023-09-13T10:30:45Z

← Older revision		Revision as of 10:30, 13 September 2023
Line 27:		Line 27:
	* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>		* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>
	* [[Renal medullary carcinoma]].		* [[Renal medullary carcinoma]].
			* Renal carcinoma (not ''rhabdoid tumour'' and not ''medullary carcinoma'').<ref>{{cite journal \|authors=Agaimy A, Hartmann A \|title=[SMARCB1(INI1)-deficient renal cell carcinoma: medullary and beyond : Evolving concepts] \|language=German \|journal=Pathologe \|volume=42 \|issue=6 \|pages=571–577 \|date=November 2021 \|pmid=34609565 \|doi=10.1007/s00292-021-00985-y \|url=}}</ref>
	* Rhabdoid carcinoma of gastrointestinal tract.<ref name=pmid24503755>{{cite journal \|authors=Agaimy A, Rau TT, Hartmann A, Stoehr R \|title=SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review \|journal=Am J Surg Pathol \|volume=38 \|issue=7 \|pages=910–20 \|date=July 2014 \|pmid=24503755 \|doi=10.1097/PAS.0000000000000173 \|url=}}</ref>		* Rhabdoid carcinoma of gastrointestinal tract.<ref name=pmid24503755>{{cite journal \|authors=Agaimy A, Rau TT, Hartmann A, Stoehr R \|title=SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review \|journal=Am J Surg Pathol \|volume=38 \|issue=7 \|pages=910–20 \|date=July 2014 \|pmid=24503755 \|doi=10.1097/PAS.0000000000000173 \|url=}}</ref>

Michael: /* References */

2021-11-25T18:22:12Z

References

← Older revision		Revision as of 18:22, 25 November 2021
Line 34:		Line 34:

	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}


	[[Category:Immunohistochemistry]]		[[Category:Immunohistochemistry]]
	[[Category:Neuropathology]]		[[Category:Neuropathology]]

Michael: /* Negative */

2021-11-25T18:21:26Z

Negative

← Older revision		Revision as of 18:21, 25 November 2021
Line 27:		Line 27:
	* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>		* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>
	* [[Renal medullary carcinoma]].		* [[Renal medullary carcinoma]].
			* Rhabdoid carcinoma of gastrointestinal tract.<ref name=pmid24503755>{{cite journal \|authors=Agaimy A, Rau TT, Hartmann A, Stoehr R \|title=SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review \|journal=Am J Surg Pathol \|volume=38 \|issue=7 \|pages=910–20 \|date=July 2014 \|pmid=24503755 \|doi=10.1097/PAS.0000000000000173 \|url=}}</ref>

	==See also==		==See also==

Michael: /* Negative */ wikify

2019-05-16T15:09:18Z

Negative: wikify

← Older revision		Revision as of 15:09, 16 May 2019
Line 23:		Line 23:
	* [[Extrarenal malignant rhabdoid tumour]].<ref>Jackson EM, Sievert AJ, Gai X et al. (March 2009). "Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors". Clin. Cancer Res. 15 (6): 1923–30.</ref>		* [[Extrarenal malignant rhabdoid tumour]].<ref>Jackson EM, Sievert AJ, Gai X et al. (March 2009). "Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors". Clin. Cancer Res. 15 (6): 1923–30.</ref>
	* [[Renal rhabdoid tumour]].		* [[Renal rhabdoid tumour]].
	* SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract.<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>		* [[SMARCB1-deficient sinonasal carcinoma\|SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>
	* [[Atypical teratoid/rhabdoid tumour]].<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>		* [[Atypical teratoid/rhabdoid tumour]].<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>
	* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>		* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>

Michael: /* Negative */

2019-03-17T17:57:26Z

Negative

← Older revision		Revision as of 17:57, 17 March 2019
Line 26:		Line 26:
	* [[Atypical teratoid/rhabdoid tumour]].<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>		* [[Atypical teratoid/rhabdoid tumour]].<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>
	* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>		* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>
			* [[Renal medullary carcinoma]].

	==See also==		==See also==

Michael at 16:23, 19 October 2018

2018-10-19T16:23:03Z

← Older revision		Revision as of 16:23, 19 October 2018
Line 17:		Line 17:
	'''SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1''', commonly abbreviated '''SMARCB1''', is a diagnostic [[immunostain]], because nuclear staining is lost in some specific types of cancer shown below.		'''SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1''', commonly abbreviated '''SMARCB1''', is a diagnostic [[immunostain]], because nuclear staining is lost in some specific types of cancer shown below.

	It is also known as '''INI1''' and '''BAF47'''.		It is also known as '''INI1''', '''INI-1''' and '''BAF47'''.

	==Negative==		==Negative==

Michael: /* See also */

2018-10-19T16:21:13Z

Jensflorian: /* Negative */ loss in some synovial sarcomas reported

2018-01-25T09:35:12Z

Negative: loss in some synovial sarcomas reported

← Older revision		Revision as of 09:35, 25 January 2018
Line 25:		Line 25:
	* SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract.<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>		* SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract.<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>
	* [[Atypical teratoid/rhabdoid tumour]].<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>		* [[Atypical teratoid/rhabdoid tumour]].<ref>{{Cite journal \| last1 = Hasselblatt \| first1 = M. \| last2 = Isken \| first2 = S. \| last3 = Linge \| first3 = A. \| last4 = Eikmeier \| first4 = K. \| last5 = Jeibmann \| first5 = A. \| last6 = Oyen \| first6 = F. \| last7 = Nagel \| first7 = I. \| last8 = Richter \| first8 = J. \| last9 = Bartelheim \| first9 = K. \| title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. \| journal = Genes Chromosomes Cancer \| volume = 52 \| issue = 2 \| pages = 185-90 \| month = Feb \| year = 2013 \| doi = 10.1002/gcc.22018 \| PMID = 23074045 }}</ref>
			* Up to 30% of [[synovial sarcoma]].<ref>{{Cite journal \| last1 = Mularz \| first1 = K. \| last2 = Harazin-Lechowska \| first2 = A. \| last3 = Ambicka \| first3 = A. \| last4 = Kruczak \| first4 = A. \| last5 = Rozmus-Piętoń \| first5 = M. \| last6 = Marchińska-Osika \| first6 = U. \| last7 = Swiątkiewicz \| first7 = I. \| last8 = Król \| first8 = M. \| last9 = Pabis \| first9 = D. \| title = Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma. Loss of INI1 expression as a frequent immunohistochemical event in synovial sarcoma. \| journal = Pol J Pathol \| volume = 63 \| issue = 3 \| pages = 179-83 \| month = Nov \| year = 2012 \| doi = \| PMID = 23161234 }}</ref>

	==See also==		==See also==

Michael at 03:41, 15 March 2016

2016-03-15T03:41:13Z

← Older revision		Revision as of 03:41, 15 March 2016
Line 15:		Line 15:
	\| Other =		\| Other =
	}}		}}
	'''SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1''', commonly abbreviated '''SMARCB1''' ~~(or '''INI1''' or '''BAF47''')~~, is a diagnostic [[immunostain]], because nuclear staining is lost in some specific types of cancer shown below.		'''SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1''', commonly abbreviated '''SMARCB1''', is a diagnostic [[immunostain]], because nuclear staining is lost in some specific types of cancer shown below.

			It is also known as '''INI1''' and '''BAF47'''.

	==Negative==		==Negative==

← Older revision		Revision as of 16:21, 19 October 2018
Line 29:		Line 29:
	==See also==		==See also==
	*[[Immunohistochemistry]].		*[[Immunohistochemistry]].
			*[[SMARCA4-deficient adenocarcinoma of the lung]].

	==References==		==References==