Reactive follicular hyperplasia - Revision history

Michael: /* Microscopic */

2021-02-16T15:25:38Z

Microscopic

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	**[[Follicular lymphoma]].		**[[Follicular lymphoma]].
	**T-cell/histiocyte-rich large B cell lymphoma.		**T-cell/histiocyte-rich large B cell lymphoma.
			**Others.

	==IHC==		==IHC==

2021-02-16T15:25:26Z

Microscopic: tweak

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	DDx:		DDx:
	*[[Hodgkin lymphoma]] - with rare Reed-Sternberg cells.		*[[Hodgkin lymphoma]] - with rare Reed-Sternberg cells.
	*Non-Hodgkin [[lymphoma]].		*Non-Hodgkin [[lymphoma]]s.
			**[[Follicular lymphoma]].
	**T-cell/histiocyte-rich large B cell lymphoma.		**T-cell/histiocyte-rich large B cell lymphoma.

	~~Image: [http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Normal lymph node (umdnj.edu)].~~

	==IHC==		==IHC==

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Images

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	===Images===		===Images===
	<gallery>Image:Follicular lymphoma - control bcl2 -- low mag.jpg\|BCL2 negative immunostaining in the germinal centers of reactive follicular hyperplasia. BCL2 immunostain.		<gallery>Image:Follicular lymphoma - control bcl2 -- low mag.jpg\|BCL2 negative immunostaining in the germinal centers of reactive follicular hyperplasia. [[BCL2\|BCL2 immunostain]].
	</gallery>		</gallery>

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Images

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	===Images===		===Images===
	[[Image:Follicular lymphoma - control bcl2 -- low mag.jpg~~\|thumb~~\|BCL2 negative immunostaining in the germinal centers of reactive follicular hyperplasia. BCL2 immunostain.]]		<gallery>Image:Follicular lymphoma - control bcl2 -- low mag.jpg\|BCL2 negative immunostaining in the germinal centers of reactive follicular hyperplasia. BCL2 immunostain.
			</gallery>

	==See also==		==See also==

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IHC

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	Others:		Others:
	*BCL2 -ve.		*BCL2 -ve.
			**Germinal centers negative.

			===Images===
			[[Image:Follicular lymphoma - control bcl2 -- low mag.jpg\|thumb\|BCL2 negative immunostaining in the germinal centers of reactive follicular hyperplasia. BCL2 immunostain.]]

	==See also==		==See also==

2021-02-16T15:18:20Z

2021-02-16T15:17:45Z

split out

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	~~#redirect~~ [[~~Lymph_node_pathology#Reactive_follicular_hyperplasia~~]]		'''Reactive follicular hyperplasia''' is a benign [[Lymph node pathology\|lymph node change]].

			==General==
			*Many causes - including: bacteria, viruses, chemicals, drugs, allergens.
			**In only approximately 10% can definitive cause be identified.<ref name=Ref_ILNP174>{{Ref_ILNP\|174}}</ref>

			==Microscopic==
			Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>
			*Enlarged follicles, follicle size variation - '''key feature''' with:
			**Large germinal centers (pale on H&E).
			***Mitoses common.
			***Variable lymphocyte morphology.
			***Tingible-body macrophage (large, pale cells with junk in the cytoplasm).
			***Germinal centers (GCs) have a crisp/sharp edge.
			***Normal dark/light variation of GCs; superficial aspect light, deeper aspect darker.
			**Rim of small (inactive) lymphocytes.

			DDx:
			*[[Hodgkin lymphoma]] - with rare Reed-Sternberg cells.
			*Non-Hodgkin [[lymphoma]].
			**T-cell/histiocyte-rich large B cell lymphoma.

			Image: [http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Normal lymph node (umdnj.edu)].

			==IHC==
			Screening panel:
			*[[CD3]].
			*[[CD5]].
			*CD10.
			*[[CD20]].
			*CD30.
			*CD15.

			Others:
			*BCL2 -ve.

			==See also==
			*[[Lymph node pathology]].

			==References==
			{{Reflist\|1}}


	[[Category:Diagnosis]]		[[Category:Diagnosis]]

2012-02-07T05:28:01Z

redirect

New page

#redirect [[Lymph_node_pathology#Reactive_follicular_hyperplasia]]

[[Category:Diagnosis]]