Plasma cell neoplasms - Revision history

Michael: /* Dutcher bodies */

2016-12-12T17:22:45Z

Dutcher bodies

← Older revision		Revision as of 17:22, 12 December 2016
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	====Dutcher bodies====		====Dutcher bodies====
	~~=====www=====~~		<gallery>
	*[http:~~//lh5.ggpht.com/--QNP_zV1j1E/SrpPM9rr2PI/AAAAAAAAA2s/ujrF4BYSBts/~~Dutcher-bodies~~-website-arrow~~.jpg Dutcher bodies (~~ggpht.com~~)~~].<ref>URL: [http://picasaweb.google.com/115272207060951660904/HistiocyteDisorders http://picasaweb.google.com/115272207060951660904/HistiocyteDisorders]. Accessed on: 10 August 2011.~~</~~ref~~>		Image: Dutcher and Russell bodies.jpg \| Dutcher bodies and Russell bodies. (WC/Gabriel Caponetti)
			</gallery>

	==IHC==		==IHC==

Michael at 17:11, 8 December 2015

2015-12-08T17:11:30Z

← Older revision		Revision as of 17:11, 8 December 2015
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	\| LMDDx = [[lymphoplasmacytic lymphoma]], [[neuroendocrine carcinoma]], poorly differentiated carcinoma, others		\| LMDDx = [[lymphoplasmacytic lymphoma]], [[neuroendocrine carcinoma]], poorly differentiated carcinoma, others
	\| Stains =		\| Stains =
	\| IHC = CD138 +ve, CD56 +ve, CD45 -ve/+ve, CD79a +ve		\| IHC = [[CD138]] +ve, CD56 +ve, CD45 -ve/+ve, CD79a +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	==IHC==		==IHC==
	*CD138 +ve.		*[[CD138]] +ve.
	*[[CD56]] +ve.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref>		*[[CD56]] +ve.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref>
	**Also +ve in NK/T cell lymphomas.		**Also +ve in NK/T cell lymphomas.

Michael: tweak

2015-11-09T14:00:46Z

tweak

← Older revision		Revision as of 14:00, 9 November 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Plasma cell neoplasm -- very high mag.jpg
			\| Width =
			\| Caption = Plasma cell neoplasm. [[H&E stain]]
			\| Synonyms =
			\| Micro = dyscohesive plasmacytoid cells (abundant cytoplasm, eccentrically placed nucleus), often prominent perinuclear hof, +/-nucleoli, +/-Russell bodies, +/-Dutcher bodies
			\| Subtypes =
			\| LMDDx = [[lymphoplasmacytic lymphoma]], [[neuroendocrine carcinoma]], poorly differentiated carcinoma, others
			\| Stains =
			\| IHC = CD138 +ve, CD56 +ve, CD45 -ve/+ve, CD79a +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[bone]] - [[bone marrow]]
			\| Assdx = [[renal failure]], [[myeloma cast nephropathy]]
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork = +/-[[anemia]], +/-hypercalcemia
			\| Rads = +/-lytic bone lesions
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx = [[metastatic disease]]
			\| Tx =
			}}
	'''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion.		'''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion.

Michael at 13:48, 9 November 2015

2015-11-09T13:48:21Z

← Older revision		Revision as of 13:48, 9 November 2015
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	==IHC==		==IHC==
			*CD138 +ve.
			*[[CD56]] +ve.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref>
			**Also +ve in NK/T cell lymphomas.
	*Kappa -- usu. slightly stronger than lambda.		*Kappa -- usu. slightly stronger than lambda.
	*Lambda.		*Lambda.
	*[[CD56]].<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref>
	**Also +ve in NK/T cell lymphomas.
	*CD57.		*CD57.
	**Also +ve in [[T-cell large granular lymphocytic leukemia]].<ref>URL: [http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html]. Accessed on: 31 August 2010.</ref>		**Also +ve in [[T-cell large granular lymphocytic leukemia]].<ref>URL: [http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html]. Accessed on: 31 August 2010.</ref>
	*~~CD138~~.		*CD38 +ve.<ref>{{Cite journal \| last1 = Tamamori \| first1 = T. \| last2 = Nakayama \| first2 = F. \| last3 = Sugimoto \| first3 = H. \| last4 = Fenxiang \| first4 = J. \| last5 = Iwatsuki \| first5 = K. \| last6 = Takigawa \| first6 = M. \| title = Extramedullary plasmacytoma: cytological and genotypic studies. \| journal = Br J Dermatol \| volume = 129 \| issue = 4 \| pages = 468-72 \| month = Oct \| year = 1993 \| doi = \| PMID = 8217765 }}</ref>
	*~~CD38~~. (~~???~~)
			Others:<ref>URL: [http://e-immunohistochemistry.info/web/Plasmacytoma_plasma_cell_myeloma.htm http://e-immunohistochemistry.info/web/Plasmacytoma_plasma_cell_myeloma.htm]. Accessed on: 9 November 2015.</ref>
			*CD79a +ve.
			*CD45 -ve/+ve.
			*CD10 -ve.
			*CD5 -ve.
			*Cyclin D1 -ve/+ve.

			A panel:<!-- need a good panel - maybe here http://clincancerres.aacrjournals.org/content/15/2/714.full or here http://e-immunohistochemistry.info/web/Plasmacytoma_plasma_cell_myeloma.htm -->
			*CD3, CD20, CD56, CD117, CD138, IG-kappa (plasma), IG-lambda (plasma).

	==Molecular==		==Molecular==

Michael at 18:46, 16 October 2015

2015-10-16T18:46:39Z

← Older revision		Revision as of 18:46, 16 October 2015
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	'''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion.		'''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion.

	~~[[VL]] does not tease apart~~ ''~~plasma~~ cell myeloma'', ''plasmacytoma'' (solitary myeloma)<ref name=Ref_PCPBoD8_324>{{Ref PCPBoD8\|324}}</ref> ~~and ''plasma cell neoplasm''; the first two of these terms~~ redirect to this article.		''Plasma cell myeloma'', and ''plasmacytoma'' (solitary myeloma)<ref name=Ref_PCPBoD8_324>{{Ref PCPBoD8\|324}}</ref> redirect to this article.

	==General==		==General==

Michael: /* Images */

2015-06-13T03:59:57Z

Images

← Older revision		Revision as of 03:59, 13 June 2015
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	===Images===		===Images===
	====Case====		=====Case=====
	<gallery>		<gallery>
	Image: Plasma cell neoplasm -- low mag.jpg \| PCN - low mag.		Image: Plasma cell neoplasm -- low mag.jpg \| PCN - low mag.
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	Image: Plasma cell neoplasm -- very high mag.jpg \| PCN - very high mag.		Image: Plasma cell neoplasm -- very high mag.jpg \| PCN - very high mag.
	</gallery>		</gallery>
	====Other cases====		=====Other cases=====
	<gallery>		<gallery>
	Image:Plasmacytoma1.jpg \| Plasmacytoma. (WC)		Image:Plasmacytoma1.jpg \| Plasmacytoma. (WC)
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	File:Plasmocytoma_smear_mann_x200.jpg \| Leptomeningeal plasmacytoma, frozen section (WC/jensflorian)		File:Plasmocytoma_smear_mann_x200.jpg \| Leptomeningeal plasmacytoma, frozen section (WC/jensflorian)
	</gallery>		</gallery>
	====www====		=====www=====
	*[http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)].		*[http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)].
	*[http://path.upmc.edu/cases/case515/images/fig05.jpg Multiple myeloma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case515.html http://path.upmc.edu/cases/case515.html]. Accessed on: 25 January 2012.</ref>		*[http://path.upmc.edu/cases/case515/images/fig05.jpg Multiple myeloma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case515.html http://path.upmc.edu/cases/case515.html]. Accessed on: 25 January 2012.</ref>
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	Image:Russell_bodies_2_high_mag_mini.jpg \| Russell bodies. (WC)		Image:Russell_bodies_2_high_mag_mini.jpg \| Russell bodies. (WC)
	</gallery>		</gallery>
	www:		=====www=====
	*[http://www.healthsystem.virginia.edu/internet/hematology/hessimages/russell-bodies-website-arrow.jpg Russell bodies (healthsystem.virginia.edu)].		*[http://www.healthsystem.virginia.edu/internet/hematology/hessimages/russell-bodies-website-arrow.jpg Russell bodies (healthsystem.virginia.edu)].
	*[http://www.pathguy.com/lectures/russ2.jpg Russell bodies - several in one cell (pathguy.com)].		*[http://www.pathguy.com/lectures/russ2.jpg Russell bodies - several in one cell (pathguy.com)].

	====Dutcher bodies====		====Dutcher bodies====
	www:		=====www=====
	*[http://lh5.ggpht.com/--QNP_zV1j1E/SrpPM9rr2PI/AAAAAAAAA2s/ujrF4BYSBts/Dutcher-bodies-website-arrow.jpg Dutcher bodies (ggpht.com)].<ref>URL: [http://picasaweb.google.com/115272207060951660904/HistiocyteDisorders http://picasaweb.google.com/115272207060951660904/HistiocyteDisorders]. Accessed on: 10 August 2011.</ref>		*[http://lh5.ggpht.com/--QNP_zV1j1E/SrpPM9rr2PI/AAAAAAAAA2s/ujrF4BYSBts/Dutcher-bodies-website-arrow.jpg Dutcher bodies (ggpht.com)].<ref>URL: [http://picasaweb.google.com/115272207060951660904/HistiocyteDisorders http://picasaweb.google.com/115272207060951660904/HistiocyteDisorders]. Accessed on: 10 August 2011.</ref>

Michael: /* Images */

2015-06-13T03:59:05Z

Images

← Older revision		Revision as of 03:59, 13 June 2015
Line 52:		Line 52:

	===Images===		===Images===
			====Case====
			<gallery>
			Image: Plasma cell neoplasm -- low mag.jpg \| PCN - low mag.
			Image: Plasma cell neoplasm -- intermed mag.jpg \| PCN - intermed. mag.
			Image: Plasma cell neoplasm -- high mag.jpg \| PCN - high mag.
			Image: Plasma cell neoplasm -- very high mag.jpg \| PCN - very high mag.
			</gallery>
			====Other cases====
	<gallery>		<gallery>
	Image:Plasmacytoma1.jpg \| Plasmacytoma. (WC)		Image:Plasmacytoma1.jpg \| Plasmacytoma. (WC)
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	File:Plasmocytoma_smear_mann_x200.jpg \| Leptomeningeal plasmacytoma, frozen section (WC/jensflorian)		File:Plasmocytoma_smear_mann_x200.jpg \| Leptomeningeal plasmacytoma, frozen section (WC/jensflorian)
	</gallery>		</gallery>
	www:		====www====
	*[http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)].		*[http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)].
	*[http://path.upmc.edu/cases/case515/images/fig05.jpg Multiple myeloma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case515.html http://path.upmc.edu/cases/case515.html]. Accessed on: 25 January 2012.</ref>		*[http://path.upmc.edu/cases/case515/images/fig05.jpg Multiple myeloma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case515.html http://path.upmc.edu/cases/case515.html]. Accessed on: 25 January 2012.</ref>

Jensflorian: /* Images */ +pics

2015-06-03T09:51:32Z

Images: +pics

← Older revision		Revision as of 09:51, 3 June 2015
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	<gallery>		<gallery>
	Image:Plasmacytoma1.jpg \| Plasmacytoma. (WC)		Image:Plasmacytoma1.jpg \| Plasmacytoma. (WC)
			File:Plasmocytoma HE high mag.jpg \| Skull base plasmacytoma, higher magnification (WC/jensflorian)
			File:Plasmocytoma_frozen_HE_x200.jpg \| Plasmacytoma smear (WC/jensflorian)
			File:Plasmocytoma_smear_mann_x200.jpg \| Leptomeningeal plasmacytoma, frozen section (WC/jensflorian)
	</gallery>		</gallery>
	www:		www:

Michael: touch

2015-02-09T23:31:26Z

touch

← Older revision		Revision as of 23:31, 9 February 2015
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	'''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion.		'''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion.

	[[VL]] does not tease apart ''plasma cell myeloma'', ''plasmacytoma'' (solitary myeloma)<ref name=Ref_PCPBoD8_324>{{Ref PCPBoD8\|324}}</ref> and ''plasma cell neoplasm''; the first two of these terms redirect to this article.		[[VL]] does not tease apart ''plasma cell myeloma'', ''plasmacytoma'' (solitary myeloma)<ref name=Ref_PCPBoD8_324>{{Ref PCPBoD8\|324}}</ref> and ''plasma cell neoplasm''; the first two of these terms redirect to this article.

Michael: /* IHC */

2014-09-13T08:03:07Z

IHC

← Older revision		Revision as of 08:03, 13 September 2014
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	*Kappa -- usu. slightly stronger than lambda.		*Kappa -- usu. slightly stronger than lambda.
	*Lambda.		*Lambda.
	*CD56.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref>		*[[CD56]].<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref>
	**Also +ve in NK/T cell lymphomas.		**Also +ve in NK/T cell lymphomas.
	*CD57.		*CD57.