Myoepithelial carcinoma - Revision history

Michael at 01:50, 19 March 2019

2019-03-19T01:50:40Z

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	'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal \| last1 = Kong \| first1 = M. \| last2 = Drill \| first2 = EN. \| last3 = Morris \| first3 = L. \| last4 = West \| first4 = L. \| last5 = Klimstra \| first5 = D. \| last6 = Gonen \| first6 = M. \| last7 = Ghossein \| first7 = R. \| last8 = Katabi \| first8 = N. \| title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 7 \| pages = 931-8 \| month = Jul \| year = 2015 \| doi = 10.1097/PAS.0000000000000452 \| PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]].<ref name=pmid9797738>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| last2 = Primrose \| first2 = WJ. \| last3 = Toner \| first3 = PG. \| title = Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma. \| journal = J Clin Pathol \| volume = 51 \| issue = 7 \| pages = 552-6 \| month = Jul \| year = 1998 \| doi = \| PMID = 9797738 }}</ref>		'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal \| last1 = Kong \| first1 = M. \| last2 = Drill \| first2 = EN. \| last3 = Morris \| first3 = L. \| last4 = West \| first4 = L. \| last5 = Klimstra \| first5 = D. \| last6 = Gonen \| first6 = M. \| last7 = Ghossein \| first7 = R. \| last8 = Katabi \| first8 = N. \| title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 7 \| pages = 931-8 \| month = Jul \| year = 2015 \| doi = 10.1097/PAS.0000000000000452 \| PMID = 25970687 }}</ref>

			It is the malignant counterpart of [[myoepithelioma]] and also known as '''malignant myoepithelioma'''.<ref name=pmid9797738>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| last2 = Primrose \| first2 = WJ. \| last3 = Toner \| first3 = PG. \| title = Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma. \| journal = J Clin Pathol \| volume = 51 \| issue = 7 \| pages = 552-6 \| month = Jul \| year = 1998 \| doi = \| PMID = 9797738 }}</ref>

	==General==		==General==

Michael at 01:48, 19 March 2019

2019-03-19T01:48:35Z

← Older revision		Revision as of 01:48, 19 March 2019
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	'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal \| last1 = Kong \| first1 = M. \| last2 = Drill \| first2 = EN. \| last3 = Morris \| first3 = L. \| last4 = West \| first4 = L. \| last5 = Klimstra \| first5 = D. \| last6 = Gonen \| first6 = M. \| last7 = Ghossein \| first7 = R. \| last8 = Katabi \| first8 = N. \| title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 7 \| pages = 931-8 \| month = Jul \| year = 2015 \| doi = 10.1097/PAS.0000000000000452 \| PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]].		'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal \| last1 = Kong \| first1 = M. \| last2 = Drill \| first2 = EN. \| last3 = Morris \| first3 = L. \| last4 = West \| first4 = L. \| last5 = Klimstra \| first5 = D. \| last6 = Gonen \| first6 = M. \| last7 = Ghossein \| first7 = R. \| last8 = Katabi \| first8 = N. \| title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 7 \| pages = 931-8 \| month = Jul \| year = 2015 \| doi = 10.1097/PAS.0000000000000452 \| PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]].<ref name=pmid9797738>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| last2 = Primrose \| first2 = WJ. \| last3 = Toner \| first3 = PG. \| title = Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma. \| journal = J Clin Pathol \| volume = 51 \| issue = 7 \| pages = 552-6 \| month = Jul \| year = 1998 \| doi = \| PMID = 9797738 }}</ref>

	==General==		==General==

Michael: /* General */

2019-03-19T01:45:03Z

General

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	==General==		==General==
	*Rare.		*Rare.
	*Often misdiagnosed as "benign".<ref name=pmid30789358>		*Often misdiagnosed as "benign".<ref name=pmid30789358/>

	==Microscopic==		==Microscopic==

Michael: /* General */

2019-03-19T01:44:54Z

General

← Older revision		Revision as of 01:44, 19 March 2019
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	==General==		==General==
	*Rare.		*Rare.
			*Often misdiagnosed as "benign".<ref name=pmid30789358>

	==Microscopic==		==Microscopic==

Michael: /* Molecular */

2019-03-19T01:43:59Z

Molecular

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	==Molecular==		==Molecular==
	*Fusions with PLAG1.<ref name=pmid29084941>{{Cite journal \| last1 = Dalin \| first1 = MG. \| last2 = Katabi \| first2 = N. \| last3 = Persson \| first3 = M. \| last4 = Lee \| first4 = KW. \| last5 = Makarov \| first5 = V. \| last6 = Desrichard \| first6 = A. \| last7 = Walsh \| first7 = LA. \| last8 = West \| first8 = L. \| last9 = Nadeem \| first9 = Z. \| title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. \| journal = Nat Commun \| volume = 8 \| issue = 1 \| pages = 1197 \| month = 10 \| year = 2017 \| doi = 10.1038/s41467-017-01178-z \| PMID = 29084941 }}</ref>		*+/-Fusions with PLAG1 gene.<ref name=pmid29084941>{{Cite journal \| last1 = Dalin \| first1 = MG. \| last2 = Katabi \| first2 = N. \| last3 = Persson \| first3 = M. \| last4 = Lee \| first4 = KW. \| last5 = Makarov \| first5 = V. \| last6 = Desrichard \| first6 = A. \| last7 = Walsh \| first7 = LA. \| last8 = West \| first8 = L. \| last9 = Nadeem \| first9 = Z. \| title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. \| journal = Nat Commun \| volume = 8 \| issue = 1 \| pages = 1197 \| month = 10 \| year = 2017 \| doi = 10.1038/s41467-017-01178-z \| PMID = 29084941 }}</ref>
			*+/-EWSR1 gene rearrangement.<ref>{{Cite journal \| last1 = Thway \| first1 = K. \| last2 = Bown \| first2 = N. \| last3 = Miah \| first3 = A. \| last4 = Turner \| first4 = R. \| last5 = Fisher \| first5 = C. \| title = Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors. \| journal = Head Neck Pathol \| volume = 9 \| issue = 2 \| pages = 273-9 \| month = Jun \| year = 2015 \| doi = 10.1007/s12105-014-0556-2 \| PMID = 24993038 }}</ref>

	==See also==		==See also==

Michael: /* Microscopic */

2019-03-19T01:40:25Z

Microscopic

← Older revision		Revision as of 01:40, 19 March 2019
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	==Microscopic==		==Microscopic==
	Features:		Features:<ref name=pmid30789358>{{Cite journal \| last1 = Xu \| first1 = B. \| last2 = Mneimneh \| first2 = W. \| last3 = Torrence \| first3 = DE. \| last4 = Higgins \| first4 = K. \| last5 = Klimstra \| first5 = D. \| last6 = Ghossein \| first6 = R. \| last7 = Katabi \| first7 = N. \| title = Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall. \| journal = Am J Surg Pathol \| volume = \| issue = \| pages = \| month = Feb \| year = 2019 \| doi = 10.1097/PAS.0000000000001218 \| PMID = 30789358 }}</ref>
	*Myoepithelial cells - may be cytologically very bland.		*Myoepithelial cells - may be cytologically very bland.
	*+/-Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation).
	*Hypocellular centre (hyaline or myxoid) and hypercellular periphery.		*Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
			*Pushing border ("expansile nodular lobulated pattern").
	*No ductal structures.		*No ductal structures.

			Note:
			*Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent.

	DDx:		DDx:

Michael at 01:33, 19 March 2019

2019-03-19T01:33:28Z

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	'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal \| last1 = Kong \| first1 = M. \| last2 = Drill \| first2 = EN. \| last3 = Morris \| first3 = L. \| last4 = West \| first4 = L. \| last5 = Klimstra \| first5 = D. \| last6 = Gonen \| first6 = M. \| last7 = Ghossein \| first7 = R. \| last8 = Katabi \| first8 = N. \| title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 7 \| pages = 931-8 \| month = Jul \| year = 2015 \| doi = 10.1097/PAS.0000000000000452 \| PMID = 25970687 }}</ref> It is the malignant counterpart of [[~~epithelioma~~]].		'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal \| last1 = Kong \| first1 = M. \| last2 = Drill \| first2 = EN. \| last3 = Morris \| first3 = L. \| last4 = West \| first4 = L. \| last5 = Klimstra \| first5 = D. \| last6 = Gonen \| first6 = M. \| last7 = Ghossein \| first7 = R. \| last8 = Katabi \| first8 = N. \| title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 7 \| pages = 931-8 \| month = Jul \| year = 2015 \| doi = 10.1097/PAS.0000000000000452 \| PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]].

	==General==		==General==

Michael: reate

2019-03-19T01:33:09Z

reate

New page

'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> It is the malignant counterpart of [[epithelioma]].

==General==
*Rare.

==Microscopic==
Features:
*Myoepithelial cells - may be cytologically very bland.
*+/-Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation).
*Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
*No ductal structures.

DDx:
*[[Pleomorphic adenoma]].
*[[Myoepithelioma]].

==IHC==
*CAM5.2 +ve.

==Molecular==
*Fusions with PLAG1.<ref name=pmid29084941>{{Cite journal | last1 = Dalin | first1 = MG. | last2 = Katabi | first2 = N. | last3 = Persson | first3 = M. | last4 = Lee | first4 = KW. | last5 = Makarov | first5 = V. | last6 = Desrichard | first6 = A. | last7 = Walsh | first7 = LA. | last8 = West | first8 = L. | last9 = Nadeem | first9 = Z. | title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. | journal = Nat Commun | volume = 8 | issue = 1 | pages = 1197 | month = 10 | year = 2017 | doi = 10.1038/s41467-017-01178-z | PMID = 29084941 }}</ref>

==See also==
*[[Salivary gland]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]
[[Category:Head and neck pathology]]