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GFAP - Revision history
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<p><b>New page</b></p><div>'''GLIAL FIBRILLARY ACIDIC PROTEIN''', abbreviated '''GFAP''',<ref>{{OMIM|137780 }}</ref> was one of the first delevloped antibodies and is a common [[immunostain]] used in [[neuropathology]]. It's expression is associated with glial differentiation, especially with astrocytes.<br />
<br />
==Positive==<br />
*Astrocytes (upregulated in reactive astrocytes) <ref>{{Cite journal | last1 = Anderson | first1 = MA. | last2 = Ao | first2 = Y. | last3 = Sofroniew | first3 = MV. | title = Heterogeneity of reactive astrocytes. | journal = Neurosci Lett | volume = 565 | issue = | pages = 23-9 | month = Apr | year = 2014 | doi = 10.1016/j.neulet.2013.12.030 | PMID = 24361547 }}</ref><br />
* [[astrocytoma]] and [[glioblastoma]]<ref>{{Cite journal | last1 = Lolait | first1 = SJ. | last2 = Harmer | first2 = JH. | last3 = Auteri | first3 = G. | last4 = Pedersen | first4 = JS. | last5 = Toh | first5 = BH. | title = Expression of glial fibrillary acidic protein, actin, fibronectin and factor VIII antigen in human astrocytomas. | journal = Pathology | volume = 15 | issue = 4 | pages = 373-8 | month = Oct | year = 1983 | doi = | PMID = 6326028 }}</ref><br />
*minigemistcytes in [[oligodendroglioma]]<ref>{{Cite journal | last1 = Herpers | first1 = MJ. | last2 = Budka | first2 = H. | title = Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytoma as subtypes of oligodendroglioma. | journal = Acta Neuropathol | volume = 64 | issue = 4 | pages = 265-72 | month = | year = 1984 | doi = | PMID = 6391068 }}</ref><br />
*[[ependymoma]] <br />
*ocassionally in [[medulloblastoma]], [[plexus apilloma]], [[schwannoma]]<ref>{{Cite journal | last1 = Reifenberger | first1 = G. | last2 = Szymas | first2 = J. | last3 = Wechsler | first3 = W. | title = Differential expression of glial- and neuronal-associated antigens in human tumors of the central and peripheral nervous system. | journal = Acta Neuropathol | volume = 74 | issue = 2 | pages = 105-23 | month = | year = 1987 | doi = | PMID = 3314309 }}</ref><br />
===Images===<br />
<gallery><br />
File:Active Astrocytes1.jpg | GFAP in astrocytes.<br />
File:Ependymoma GFAP.jpg | GFAP in [[ependymoma]]<br />
File:Glioblastoma GFAP.jpg | GFAP in [[glioblastoma]]<br />
File:Neuropathology case IX 04.jpg | GFAP in [[glioblastoma]]<br />
File:PXA GFAP IHC.jpg | GFAP in [[PXA]]<br />
File:Anaplastic astrocytoma - gfap - very high mag.jpg| GFAP in [[astrocytoma]]<br />
File:SEGA GFAP x100.jpg | GFAP in [[SEGA]]<br />
</gallery><br />
<br />
===Negative===<br />
See<ref>{{Cite journal | last1 = Gottschalk | first1 = J. | last2 = Szymaś | first2 = J. | title = [Significance of immunohistochemistry for neuro-oncology. VI. Occurrence, localization and distribution of glial fibrillary acid protein (GFAP) in 820 tumors]. | journal = Zentralbl Allg Pathol | volume = 133 | issue = 4 | pages = 319-30 | month = | year = 1987 | doi = | PMID = 3425011 }}</ref><br />
*Meningioma<br />
*Lymphoma<br />
*Carcinoma<br />
*Melanoma<br />
*Chordoma<br />
*Paraganglioma<br />
<br />
<br />
==See also==<br />
*[[Immunohistochemistry]].<br />
<br />
==References==<br />
{{Reflist|1}}<br />
<br />
[[Category:Immunohistochemistry]]<br />
[[Category:Neuropathology]]</div>
Jensflorian