Electron microscopy - Revision history

Michael: +link to fixation

2014-02-04T15:29:03Z

+link to fixation

← Older revision		Revision as of 15:29, 4 February 2014
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	This article collection ~~stuffs about~~ '''electron microscopy'''. It is commonly abbreviated '''EM'''.		This article is a brief collection things '''electron microscopy'''. It is commonly abbreviated '''EM'''.

			[[Fixation]] for EM is often done with glutaraldehyde.<ref name=pmid8787969>{{Cite journal \| last1 = Prentø \| first1 = P. \| title = Glutaraldehyde for electron microscopy: a practical investigation of commercial glutaraldehydes and glutaraldehyde-storage conditions. \| journal = Histochem J \| volume = 27 \| issue = 11 \| pages = 906-13 \| month = Nov \| year = 1995 \| doi = \| PMID = 8787969 }}</ref>

	=Ultrastructural findings=		=Ultrastructural findings=

Michael: /* General */

2012-06-01T14:16:47Z

General

← Older revision		Revision as of 14:16, 1 June 2012
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	===General===		===General===
	*Seen in [[acinic cell carcinoma]].		*Seen in [[acinic cell carcinoma]].
	*[[Pancreas]].		*[[Pancreas]] - acinar cell.<ref name=pmid11030603>{{Cite journal \| last1 = Gorelick \| first1 = FS. \| last2 = Otani \| first2 = T. \| title = Mechanisms of intracellular zymogen activation. \| journal = Baillieres Best Pract Res Clin Gastroenterol \| volume = 13 \| issue = 2 \| pages = 227-40 \| month = Jul \| year = 1999 \| doi = \| PMID = 11030603 }}
			</ref>

	===Ultrastructure===		===Ultrastructure===

Michael: /* Tonofilaments */ +zymogen granules

2012-06-01T14:13:01Z

Tonofilaments: +zymogen granules

← Older revision		Revision as of 14:13, 1 June 2012
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	===Ultrastructure===		===Ultrastructure===
	~~Feature~~:		Features:
	*Filamentous structures at the cell periphery - vaguely resemble striated muscle.		*Filamentous structures at the cell periphery - vaguely resemble striated muscle.

	Image(s):		Image(s):
	*[http://www.bioscience.org/atlases/tumpath/em/tonofila.htm Tonofilaments (bioscience.org)].		*[http://www.bioscience.org/atlases/tumpath/em/tonofila.htm Tonofilaments (bioscience.org)].

			==Zymogen granules==
			===General===
			*Seen in [[acinic cell carcinoma]].
			*[[Pancreas]].

			===Ultrastructure===
			Features:
			*Round structures ~0.5-1.5 μm.

			Images:
			*[http://db2.photoresearchers.com/preview/9C3411.html Zymogen granules (photoresearchers.com)].
			*[http://www3.mpibpc.mpg.de/groups/em/Gallery/Pnacreas/158wt1.jpg Zymogen granules (mpg.de)].<ref>URL: [http://www3.mpibpc.mpg.de/groups/em/Gallery.htm http://www3.mpibpc.mpg.de/groups/em/Gallery.htm]. Accessed on: 1 June 2012.</ref>

	=Specific diagnoses=		=Specific diagnoses=

Michael: /* Tonofilaments */ +ref

2012-05-05T19:50:52Z

Tonofilaments: +ref

← Older revision		Revision as of 19:50, 5 May 2012
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	*Found in epithelial cells.		*Found in epithelial cells.
	*Part of the cytoskeleton.		*Part of the cytoskeleton.
			*May be found in the epithelioid component of a biphasic [[synovial sarcoma]].<ref name=pmid9930576>{{Cite journal \| last1 = Fisher \| first1 = C. \| title = Synovial sarcoma. \| journal = Ann Diagn Pathol \| volume = 2 \| issue = 6 \| pages = 401-21 \| month = Dec \| year = 1998 \| doi = \| PMID = 9930576 }}</ref>

	===Ultrastructure===		===Ultrastructure===

Michael: /* Birbeck granules */

2012-05-05T19:48:24Z

Birbeck granules

← Older revision		Revision as of 19:48, 5 May 2012
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	*[http://media.photobucket.com/image/birbeck+granules+/cat_at_uw/Annotated%2520Remembrances/BirbeckGranules.jpg Birbeck granules (photobucket.com)].		*[http://media.photobucket.com/image/birbeck+granules+/cat_at_uw/Annotated%2520Remembrances/BirbeckGranules.jpg Birbeck granules (photobucket.com)].
	**Usually... only the handle of the tennis racket is well seen.		**Usually... only the handle of the tennis racket is well seen.

			==Tonofilaments==
			===General===
			*Found in epithelial cells.
			*Part of the cytoskeleton.

			===Ultrastructure===
			Feature:
			*Filamentous structures at the cell periphery - vaguely resemble striated muscle.

			Image(s):
			*[http://www.bioscience.org/atlases/tumpath/em/tonofila.htm Tonofilaments (bioscience.org)].

	=Specific diagnoses=		=Specific diagnoses=

Michael: rework

2012-05-05T02:07:48Z

rework

← Older revision		Revision as of 02:07, 5 May 2012
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	This article collection stuffs about '''electron microscopy'''. It is commonly abbreviated '''EM'''.		This article collection stuffs about '''electron microscopy'''. It is commonly abbreviated '''EM'''.

			=Ultrastructural findings=
	==Glycogen==		==Glycogen==
			===General===
			Seen in:
			*[[Glycogen storage disorders]].
			*[[Ewing sarcoma]].

			===Ultrastructure===
	Appearance:		Appearance:
	*Cytoplasmic, electron dense, not bound by a membrane.		*Cytoplasmic, electron dense, not bound by a membrane.

	~~Seen in:~~
	*[[Glycogen storage disorders]].

	==Tubuloreticular inclusions==		==Tubuloreticular inclusions==
	Abbreviated ''TRIs''.		Abbreviated ''TRIs''.
			===General===
			Seen in:
			*[[Dermatomyositis]].
			*[[Inclusion body myositis]].

			===Ultrastructure===
	Appearance:		Appearance:
	*Undulating tubules in the smooth ER, usu. perinuclear.<ref name=pmid19330338>{{cite journal \|author=Stoltenburg-Didinger G, Genth E \|title=[Dermatomyositis] \|language=German \|journal=Z Rheumatol \|volume=68 \|issue=4 \|pages=287–94 \|year=2009 \|month=June \|pmid=19330338 \|doi=10.1007/s00393-008-0398-y \|url=}}</ref>		*Undulating tubules in the smooth ER, usu. perinuclear.<ref name=pmid19330338>{{cite journal \|author=Stoltenburg-Didinger G, Genth E \|title=[Dermatomyositis] \|language=German \|journal=Z Rheumatol \|volume=68 \|issue=4 \|pages=287–94 \|year=2009 \|month=June \|pmid=19330338 \|doi=10.1007/s00393-008-0398-y \|url=}}</ref>

			==Melanosomes==
			===General===
	Seen in:		Seen in:
	*[[~~Dermatomyositis]].~~		*[[Melanoma]].
	*[[Inclusion body myositis]].

	==~~Melanosomes~~==		===Ultrastructure===
	Appearance:		Appearance:
	*Membrane bound, sausage-like shape.		*Membrane bound, sausage-like shape.
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	Image(s):		Image(s):
	*[http://www.nature.com/nrm/journal/v8/n10/fig_tab/nrm2258_F1.html Melanosomes (nature.com)].		*[http://www.nature.com/nrm/journal/v8/n10/fig_tab/nrm2258_F1.html Melanosomes (nature.com)].

	~~Seen in:~~
	*[[Melanoma]].

	==Neurosecretory granules==		==Neurosecretory granules==
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	==Birbeck granules==		==Birbeck granules==
			===General===
	*Seen in [[Langerhans cell histiocytosis]].		*Seen in [[Langerhans cell histiocytosis]].

			===Ultrastructure===
	Appearance:		Appearance:
	*Electron dense, cytoplasmic tennis racket-like body.		*Electron dense, cytoplasmic tennis racket-like body.
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	**Usually... only the handle of the tennis racket is well seen.		**Usually... only the handle of the tennis racket is well seen.

			=Specific diagnoses=
	==Malignant mesothelioma==		==Malignant mesothelioma==
	{{Main\|Malignant mesothelioma}}		{{Main\|Malignant mesothelioma}}
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	*Quantity of intermediate filaments -- mesothelioma have more.		*Quantity of intermediate filaments -- mesothelioma have more.

	==See also==		=See also=
	*[[Microscope]].		*[[Microscope]].
	*[[Medical kidney diseases]].		*[[Medical kidney diseases]].

	==References==		=References=
	{{reflist\|2}}		{{reflist\|2}}

	==External links==		=External links=
	*[http://www.uni-mainz.de/FB/Medizin/Anatomie/workshop/EM/EMGlykogenE.html Electron microscopy atlas (uni-mainz.de)].		*[http://www.uni-mainz.de/FB/Medizin/Anatomie/workshop/EM/EMGlykogenE.html Electron microscopy atlas (uni-mainz.de)].

	[[Category:Weird stuff]]		[[Category:Weird stuff]]

Michael: /* References */ chg ref list

2012-05-05T02:05:12Z

References: chg ref list

← Older revision		Revision as of 02:05, 5 May 2012
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	==References==		==References==
	{{reflist}}		{{reflist\|2}}

	==External links==		==External links==

Michael: /* General */ +ref

2012-05-05T02:04:53Z

General: +ref

← Older revision		Revision as of 02:04, 5 May 2012
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	Seen in:		Seen in:
	*[[Neuroendocrine carcinoma]].		*[[Neuroendocrine carcinoma]].
	**[[Merkel cell carcinoma]].		**[[Merkel cell carcinoma]].<ref name=pmid9062165>{{Cite journal \| last1 = Gil-Moreno \| first1 = A. \| last2 = Garcia-Jiménez \| first2 = A. \| last3 = González-Bosquet \| first3 = J. \| last4 = Esteller \| first4 = M. \| last5 = Castellví-Vives \| first5 = J. \| last6 = Martínez Palones \| first6 = JM. \| last7 = Xercavins \| first7 = J. \| title = Merkel cell carcinoma of the vulva. \| journal = Gynecol Oncol \| volume = 64 \| issue = 3 \| pages = 526-32 \| month = Mar \| year = 1997 \| doi = \| PMID = 9062165 }}</ref>

	===Ultrastructure===		===Ultrastructure===

Michael: /* Dense-core granule */ rework, rename

2012-05-05T02:03:49Z

Dense-core granule: rework, rename

← Older revision		Revision as of 02:03, 5 May 2012
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	*[[Melanoma]].		*[[Melanoma]].

	==~~Dense-core granule~~==		==Neurosecretory granules==
	*[[AKA]] ''~~neurosecretory~~ granules''.		*[[AKA]] ''dense-core granules''.

			===General===
			Seen in:
			*[[Neuroendocrine carcinoma]].
			**[[Merkel cell carcinoma]].

			===Ultrastructure===
	Appearance:<ref>URL: [http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html]. Accessed on: 11 February 2011.</ref>		Appearance:<ref>URL: [http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html]. Accessed on: 11 February 2011.</ref>
	*Round membrane bound, granular core.		*Round membrane bound, granular core.
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	Image(s):		Image(s):
	*[http://pathhsw5m54.ucsf.edu/case7/image77.html Neuroendocrine tumours (ucsf.edu)].		*[http://pathhsw5m54.ucsf.edu/case7/image77.html Neuroendocrine tumours (ucsf.edu)].

	~~Seen in:~~
	*[[Neuroendocrine carcinoma]]s.

	==Birbeck granules==		==Birbeck granules==

Michael: /* Dense-core granule */

2012-05-05T01:58:33Z

Dense-core granule

← Older revision		Revision as of 01:58, 5 May 2012
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	==Dense-core granule==		==Dense-core granule==
	*[[AKA]] neurosecretory granules		*[[AKA]] ''neurosecretory granules''.

	Appearance:<ref>URL: [http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html]. Accessed on: 11 February 2011.</ref>		Appearance:<ref>URL: [http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html]. Accessed on: 11 February 2011.</ref>