Diffuse large B-cell lymphoma - Revision history

Jensflorian: /* General */ risk factors added

2017-03-29T10:46:25Z

General: risk factors added

← Older revision		Revision as of 10:46, 29 March 2017
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	*Most common form of non-Hodgkin lymphoma (in the USA).<ref name=Ref_PCPBoD8_321>{{Ref PCPBoD8\|321}}</ref>		*Most common form of non-Hodgkin lymphoma (in the USA).<ref name=Ref_PCPBoD8_321>{{Ref PCPBoD8\|321}}</ref>
	*Most common lymphoma of the [[spleen]].<ref name=pmid22924843>{{Cite journal \| last1 = Shimizu-Kohno \| first1 = K. \| last2 = Kimura \| first2 = Y. \| last3 = Kiyasu \| first3 = J. \| last4 = Miyoshi \| first4 = H. \| last5 = Yoshida \| first5 = M. \| last6 = Ichikawa \| first6 = R. \| last7 = Niino \| first7 = D. \| last8 = Ohshima \| first8 = K. \| title = Malignant lymphoma of the spleen in Japan: a clinicopathological analysis of 115 cases. \| journal = Pathol Int \| volume = 62 \| issue = 9 \| pages = 577-82 \| month = Sep \| year = 2012 \| doi = 10.1111/j.1440-1827.2012.02844.x \| PMID = 22924843 }}</ref>		*Most common lymphoma of the [[spleen]].<ref name=pmid22924843>{{Cite journal \| last1 = Shimizu-Kohno \| first1 = K. \| last2 = Kimura \| first2 = Y. \| last3 = Kiyasu \| first3 = J. \| last4 = Miyoshi \| first4 = H. \| last5 = Yoshida \| first5 = M. \| last6 = Ichikawa \| first6 = R. \| last7 = Niino \| first7 = D. \| last8 = Ohshima \| first8 = K. \| title = Malignant lymphoma of the spleen in Japan: a clinicopathological analysis of 115 cases. \| journal = Pathol Int \| volume = 62 \| issue = 9 \| pages = 577-82 \| month = Sep \| year = 2012 \| doi = 10.1111/j.1440-1827.2012.02844.x \| PMID = 22924843 }}</ref>
			*Obesity is a risk factor.<ref>{{Cite journal \| last1 = Castillo \| first1 = JJ. \| last2 = Ingham \| first2 = RR. \| last3 = Reagan \| first3 = JL. \| last4 = Furman \| first4 = M. \| last5 = Dalia \| first5 = S. \| last6 = Mitri \| first6 = J. \| title = Obesity is associated with increased relative risk of diffuse large B-cell lymphoma: a meta-analysis of observational studies. \| journal = Clin Lymphoma Myeloma Leuk \| volume = 14 \| issue = 2 \| pages = 122-30 \| month = Apr \| year = 2014 \| doi = 10.1016/j.clml.2013.10.005 \| PMID = 24360912 }}</ref>
			*Suscepibility loci located on 6p, 2p and 8q.<ref>{{Cite journal \| last1 = Cerhan \| first1 = JR. \| last2 = Berndt \| first2 = SI. \| last3 = Vijai \| first3 = J. \| last4 = Ghesquières \| first4 = H. \| last5 = McKay \| first5 = J. \| last6 = Wang \| first6 = SS. \| last7 = Wang \| first7 = Z. \| last8 = Yeager \| first8 = M. \| last9 = Conde \| first9 = L. \| title = Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. \| journal = Nat Genet \| volume = 46 \| issue = 11 \| pages = 1233-8 \| month = Nov \| year = 2014 \| doi = 10.1038/ng.3105 \| PMID = 25261932 }}</ref>

	==Microscopic==		==Microscopic==

Michael: tweak

2016-10-17T15:34:56Z

tweak

← Older revision		Revision as of 15:34, 17 October 2016
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg		\| Image = Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg
	\| Width =		\| Width =
	\| Caption = DLBCL - cytology.		\| Caption = DLBCL - cytology.

Michael: /* Images */

2016-01-16T04:16:55Z

Images

← Older revision		Revision as of 04:16, 16 January 2016
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	===Images===		===Images===
	~~<gallery>~~
	~~Image:Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg \| DLBCL - cytology (WC)~~
	~~</gallery>~~
	<gallery>		<gallery>
	Image: Diffuse large B cell lymphoma (1) tonsil.jpg \| DLBCL. (WC/KGH)		Image: Diffuse large B cell lymphoma (1) tonsil.jpg \| DLBCL. (WC/KGH)
	Image: Diffuse large B cell lymphoma (2) tonsil.jpg \| DLBCL. (WC/KGH)		Image: Diffuse large B cell lymphoma (2) tonsil.jpg \| DLBCL. (WC/KGH)
	Image: Diffuse large B cell lymphoma (3) tonsil.jpg \| DLBCL. (WC/KGH)		Image: Diffuse large B cell lymphoma (3) tonsil.jpg \| DLBCL. (WC/KGH)
			</gallery>
			<gallery>
			Image: DLBCL of testis - 2 -- intermed mag.jpg \| DLBCL (testis) - intermed. mag. (WC)
			Image: DLBCL of testis - 2 -- high mag.jpg \| DLBCL (testis) - high mag. (WC)
			Image: DLBCL of testis - 2 -- very high mag.jpg \| DLBCL (testis) - very high mag. (WC)
			</gallery>
			<gallery>
			Image:Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg \| DLBCL - cytology (WC)
	</gallery>		</gallery>

Michael at 05:44, 11 June 2015

2015-06-11T05:44:33Z

← Older revision		Revision as of 05:44, 11 June 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg		\| Image = Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg
	\| Width =		\| Width =
	\| Caption = DLBCL - cytology.		\| Caption = DLBCL - cytology.

Michael: /* panel */ clean

2015-05-04T06:33:59Z

panel: clean

← Older revision		Revision as of 06:33, 4 May 2015
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	{{familytree/end}}		{{familytree/end}}

	===~~"UHN~~ panel"===		===A panel===
	*H&E 2 micrometers.		*H&E 2 micrometers.
	*CD20 -- B cells.		*CD20 -- B cells.

Michael: /* Images */

2015-02-22T06:35:58Z

Images

← Older revision		Revision as of 06:35, 22 February 2015
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	<gallery>		<gallery>
	Image:Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg \| DLBCL - cytology (WC)		Image:Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg \| DLBCL - cytology (WC)
			</gallery>
			<gallery>
			Image: Diffuse large B cell lymphoma (1) tonsil.jpg \| DLBCL. (WC/KGH)
			Image: Diffuse large B cell lymphoma (2) tonsil.jpg \| DLBCL. (WC/KGH)
			Image: Diffuse large B cell lymphoma (3) tonsil.jpg \| DLBCL. (WC/KGH)
	</gallery>		</gallery>

Michael: /* Microscopic */ re-arrange, tweak

2014-10-28T04:52:07Z

Microscopic: re-arrange, tweak

← Older revision		Revision as of 04:52, 28 October 2014
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	Notes:		Notes:
	*Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]].		*Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]].

			===Differential diagnosis===
			*[[Carcinoma]] - esp. [[small cell carcinoma]].
			*[[Anaplastic large cell lymphoma]] (ALCL).
			*[[Follicular lymphoma]].
			**If a nodular architecture is present it is follicular lymphoma.
			*[[Post-transplant lymphoproliferative disorder]] (PTLD) - in organ transplant recipients.
			*Primary effusion lymphoma - seen in [[HIV]] infections.
			*Mixed cellularity [[Hodgkin lymphoma]] - esp. for T-cell/histiocyte-rich large B cell lymphoma.
			*B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma.<ref name=pmid22222636>{{Cite journal \| last1 = Gualco \| first1 = G. \| last2 = Natkunam \| first2 = Y. \| last3 = Bacchi \| first3 = CE. \| title = The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases. \| journal = Mod Pathol \| volume = \| issue = \| pages = \| month = Jan \| year = 2012 \| doi = 10.1038/modpathol.2011.200 \| PMID = 22222636 \| URL = http://www.nature.com/modpathol/journal/vaop/ncurrent/full/modpathol2011200a.html }}</ref>
			*Other [[small round cell tumours]].

	===Images===		===Images===
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	*Primary effusion lymphoma - associated with [[human immunodeficiency virus]].		*Primary effusion lymphoma - associated with [[human immunodeficiency virus]].
	*Lymphomatoid granulomatosis.		*Lymphomatoid granulomatosis.

	~~===Differential diagnosis===~~
	*Carcinoma.
	*[[Anaplastic large cell lymphoma]] (ALCL).
	*[[Follicular lymphoma]].
	**If a nodular architecture is present it is follicular lymphoma.
	*[[Post-transplant lymphoproliferative disorder]] (PTLD) - in organ transplant recipients.
	*Primary effusion lymphoma - seen in [[HIV]] infections.
	*Mixed cellularity [[Hodgkin lymphoma]] - esp. for T-cell/histiocyte-rich large B cell lymphoma.
	*B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma.<ref name=pmid22222636>{{Cite journal \| last1 = Gualco \| first1 = G. \| last2 = Natkunam \| first2 = Y. \| last3 = Bacchi \| first3 = CE. \| title = The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases. \| journal = Mod Pathol \| volume = \| issue = \| pages = \| month = Jan \| year = 2012 \| doi = 10.1038/modpathol.2011.200 \| PMID = 22222636 \| URL = http://www.nature.com/modpathol/journal/vaop/ncurrent/full/modpathol2011200a.html }}</ref>

	==IHC==		==IHC==

Michael: tweak

2014-10-28T04:49:35Z

tweak

← Older revision		Revision as of 04:49, 28 October 2014
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	</gallery>		</gallery>

	==Special subtypes of diffuse large B-cell lymphoma==		===Special subtypes of diffuse large B-cell lymphoma===
	*[[Primary mediastinal B-cell lymphoma]] (PMBL) - esp. in young adults.		*[[Primary mediastinal B-cell lymphoma]] (PMBL) - esp. in young adults.
	*T-cell/histiocyte-rich large B cell lymphoma.		*T-cell/histiocyte-rich large B cell lymphoma.
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	*Lymphomatoid granulomatosis.		*Lymphomatoid granulomatosis.

	==Differential diagnosis==		===Differential diagnosis===
	*Carcinoma.		*Carcinoma.
	*[[Anaplastic large cell lymphoma]] (ALCL).		*[[Anaplastic large cell lymphoma]] (ALCL).

Michael: /* Microscopic */

2014-06-17T20:15:16Z

Microscopic

← Older revision		Revision as of 20:15, 17 June 2014
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	**Cytoplasm usually basophilic and moderate in abundance.		**Cytoplasm usually basophilic and moderate in abundance.
	**+/-Prominent nucleoli, may be peripheral and/or multiple.		**+/-Prominent nucleoli, may be peripheral and/or multiple.
	*'''Not''' follicular - nodular arrangement.		*'''Not''' follicular/nodular arrangement.
	**Follicular arrangement = [[follicular lymphoma]].		**Follicular arrangement = [[follicular lymphoma]].

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	*Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]].		*Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in [[Hodgkin lymphoma]].

	Images:		===Images===
	*[http://commons.wikimedia.org/wiki/File:Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg DLBCL - cytology (WC)].		<gallery>
			Image:Diffuse_large_B_cell_lymphoma_-_cytology_low_mag.jpg \| DLBCL - cytology (WC)
			</gallery>

	==Special subtypes of diffuse large B-cell lymphoma==		==Special subtypes of diffuse large B-cell lymphoma==

Michael at 20:14, 27 December 2013

2013-12-27T20:14:16Z

← Older revision		Revision as of 20:14, 27 December 2013
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	*MUM1 -- B cells.		*MUM1 -- B cells.
	*CD21 -- highlight FDC networks if present.		*CD21 -- highlight FDC networks if present.
	*CD23 -- highlight FDC networks if present.		*[[CD23]] -- highlight FDC networks if present.
	*MIB1 -- proliferative rate.		*MIB1 -- proliferative rate.
	*EBER -- [[EBV]].		*EBER -- [[EBV]].