Basics - Revision history

Michael: found by AC - fixed

2016-07-14T03:29:56Z

found by AC - fixed

← Older revision		Revision as of 03:29, 14 July 2016
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	*A collection of PMNs... think about ''necrosis'' and ''abscess''.		*A collection of PMNs... think about ''necrosis'' and ''abscess''.

	===Lymph node ~~metstatsis~~===		===Lymph node metastasis===
	{{Main\|Lymph node metastasis}}		{{Main\|Lymph node metastasis}}
	*Take a good to look at the tumour first.		*Take a good to look at the tumour first.
	*Tumour in a node is often better differentiated than the most poorly differentiated part in the primary site.		*Tumour in a node is often better differentiated than the most poorly differentiated part in the primary site.
	*Subcapsular space - the first place to look for mets.		*Subcapsular space - the first place to look for mets.
	*Lymph node ~~metstasis~~ are usually obvious.		*Lymph node metastasis are usually obvious.
	**There are of course exceptions, e.g. [[small cell carcinoma]], [[invasive lobular carcinoma]].		**There are of course exceptions, e.g. [[small cell carcinoma]], [[invasive lobular carcinoma]].
	*Histiocytes may be difficult to separate from tumour - especially for the novice.		*Histiocytes may be difficult to separate from tumour - especially for the novice.

Michael: /* Morphologic patterns */

2015-10-31T02:50:17Z

Morphologic patterns

← Older revision		Revision as of 02:50, 31 October 2015
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	===Morphologic patterns===		===Morphologic patterns===
	{{Main\|Morphologic patterns}}		{{Main\|Morphologic patterns}}
			This covers things like ''cribriform'', ''hobnail'', ''herring bone'' and many others.

	===Nuclear destruction words===		===Nuclear destruction words===

Michael: /* Morphologic patterns */

2015-10-31T02:49:28Z

Morphologic patterns

← Older revision		Revision as of 02:49, 31 October 2015
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	*''Argyrophilic'' means has an affinity for silver<ref>URL: [http://www.merriam-webster.com/medical/argyrophilic http://www.merriam-webster.com/medical/argyrophilic]. Accessed on: 29 August 2011.</ref><ref>URL: [http://en.wiktionary.org/wiki/argyrophilic http://en.wiktionary.org/wiki/argyrophilic]. Accessed on: 29 August 2011.</ref>/loves silver/stains with silver.		*''Argyrophilic'' means has an affinity for silver<ref>URL: [http://www.merriam-webster.com/medical/argyrophilic http://www.merriam-webster.com/medical/argyrophilic]. Accessed on: 29 August 2011.</ref><ref>URL: [http://en.wiktionary.org/wiki/argyrophilic http://en.wiktionary.org/wiki/argyrophilic]. Accessed on: 29 August 2011.</ref>/loves silver/stains with silver.
	===Morphologic patterns===		===Morphologic patterns===
	{\| ~~class="wikitable sortable" style="margin-left:auto;margin-right:auto"~~		{{Main\|Morphologic patterns}}
	~~! Name of pattern~~
	~~! Meaning~~
	~~! DDx (incomplete/abbrev. list)~~
	~~! Image~~
	\|-
	~~\| Hobnail~~
	~~\| basement membrane area < area exposed to luminal surface~~
	~~\| [[angiosarcoma]], clear cell carcinoma~~
	~~\| [[Image:Epithelioid_angiosarcoma_-_very_high_mag.jpg \|thumb\|center\|150px\| [[Angiosarcoma]] - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Storiform~~
	\| spiral appearance ''or'' cartwhell pattern<ref>Storiform. dictionary.com. URL: [http://dictionary.reference.com/browse/storiform http://dictionary.reference.com/browse/storiform]. Accessed on: April 24, 2009.</ref>
	~~\| [[solitary fibrous tumour]], [[DFSP]], [[dermatofibroma]], [[UPS]]~~
	~~\| [[Image:Storiform_pattern_-_very_high_mag.jpg \| thumb\| center\|150px\| [[DFSP]] - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Fascicular~~
	~~\| the long axis of the (spindle) cells are perpendicular to one another in adjacent bundles of cells~~
	~~\| [[leiomyoma]], [[leiomyosarcoma]]~~
	~~\| [[Image:Cutaneous_leiomyosarcoma_-_very_high_mag.jpg\| thumb \| center \| 150px \| [[Leiomyosarcoma]] - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Plexiform~~
	~~\| web-like formation<ref>URL: [http://www.mondofacto.com/facts/dictionary?plexiform http://www.mondofacto.com/facts/dictionary?plexiform]. Accessed on: March 9, 2010.</ref>~~
	~~\| [[plexiform neurofibroma]], [[MPNST]], plexiform lesion of [[pulmonary hypertension]]~~
	~~\| [http://www.flickr.com/photos/bc_the_path/1715728630/ plexiform lesion of Pulm. HTn (flickr.com)]~~
	\|-
	~~\| Cribriform~~
	~~\| pierced with small holes<ref>URL: [http://dictionary.reference.com/browse/cribriform http://dictionary.reference.com/browse/cribriform]. Accessed on: 8 August 2011.</ref>~~
	~~\| cribriform [[DCIS]], cribriform [[HGPIN]], cribriforming in a [[tubular adenoma of the gastrointestinal tract\|tubular adenoma]] with high-grade dysplasia, endometrioid endometrial carcinoma~~
	~~\| [[Image:Atypical_ductal_hyperplasia_-_very_high_mag.jpg\|thumb\|center\|150px\|Cribriform architecure ([[ADH]]) - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Solid ''or'' Sheeting~~
	~~\| no architecture - back-to-back cells with no pattern apparent / no spaces between cells~~
	~~\| solid DCIS, poorly-differentiated malignancy (carcinoma, sarcoma, lymphoma)~~
	~~\| [[Image:Merkel_cell_carcinoma_-_high_mag.jpg\|thumb\|center\|150px\|Sheeting in a [[Merkel cell carcinoma]] - high mag. (WC/Nephron)]]~~
	\|-
	~~\| Micropapillary~~
	\| nipple like projections without a fibrovascular core (papillary = nipple-like<ref>URL: [http://dictionary.reference.com/browse/papillary http://dictionary.reference.com/browse/papillary]. Accessed on: 8 August 2011.</ref>)
	~~\| micropapillary [[DCIS]], micropapillary [[HGPIN]]~~
	~~\| [[File:Invasive_micropapillary_carcinoma_of_the_breast.jpg\|thumb\|center\|150px\|Micropapillary carcinoma. (WC)]]~~
	\|-
	~~\| Papillary~~
	~~\| nipple-like projection with a fibrovascular core~~
	~~\| [[papillary thyroid carcinoma]]~~
	~~\| [[Image:Papillary_renal_cell_carcinoma_high_mag.jpg\| thumb\|center\|150px\|[[Papillary RCC]] - high mag. (WC/Nephron)]]~~
	\|-
	~~\| Flat~~
	~~\| board-like, does not have a projection above the surface~~
	~~\| flat DCIS~~
	\| [http://www.breastpathology.info/Sloane/Images/dcis/flat1-400.jpg flat DCIS 1 (breastpathology.info)],<ref name=sloane/> [http://www.breastpathology.info/Sloane/Images/dcis/flat2-400.jpg flat DCIS 2 (breastpathology.info)]<ref name=sloane>URL: [http://www.breastpathology.info/Sloane/dcis.html http://www.breastpathology.info/Sloane/dcis.html]. Accessed on: 8 August 2011.</ref>
	\|-
	~~\| Herring bone~~
	~~\| like herring bone (technique) for climbing a hill in cross country skiing; books on a shelf, where they have partially fallen over -- on the one shelf to the left and the one below to the right~~
	~~\| [[fibrosarcoma]], [[synovial sarcoma]], [[MPNST]]~~
	~~\| [[Image:Malignant_peripheral_nerve_sheath_tumour_-_high_mag.jpg\|thumb\|center\|150px\| [[MPNST]] - high mag.(WC/Nephron)]]~~
	\|-
	~~\| [[Trabecular]] ''or'' cords~~
	\| trabecula = ''little beam''<ref>URL: [http://dictionary.reference.com/browse/trabecula http://dictionary.reference.com/browse/trabecula]. Accessed on: 26 December 2010.</ref>; quasi-linear arrangement of cells
	~~\| normal liver lobule, [[Sertoli cell tumour]]~~
	~~\| [[Image:Papillary thyroid carcinoma tall cell var high mag.jpg\|thumb\|center\|150px\|[[PTC]] tall cell variant - high mag. (WC/Nephron)]]~~
	\|-
	~~\| Nested (nesting)~~
	~~\| islands of cells with a circular outline~~
	~~\| neuroendocrine tumours~~
	~~\| [[Image:Small_intestine_neuroendocrine_tumour_high_mag_cropped.jpg \|thumb\|center\|150px\|[[Neuroendocrine tumour]] - low mag. (WC/Nephron)]]~~
	\|-
	~~\| Biphasic / multiple patterns~~
	~~\| multiple~~ patterns ~~or cell types; e.g. spindle cells and epithelioid cells~~
	~~\| [[synovial sarcoma]], [[malignant melanoma]], [[pleomorphic adenoma]], [[angiomyolipoma]], [[chondroid syringoma]]~~
	~~\| [[Image:Desmoplastic_small_round_cell_tumour_-_high_mag.jpg \|thumb\|center\|150px\| [[DSRCT]] - high mag. (WC/Nephron)]]~~
	\|}

	===Nuclear destruction words===		===Nuclear destruction words===

Michael: /* Estimating field of view */

2015-09-25T17:49:15Z

Estimating field of view

← Older revision		Revision as of 17:49, 25 September 2015
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	Note:		Note:
	Most ~~of the resident~~ [[microscope]]s~~, at U of T~~, have an eye piece diameter of 22 mm. Therefore, the field diameter at 40 X is approximately 22 mm / 40 X ~= 0.55 mm and the field of view is pi/4(0.55 mm)^2 = 0.2376 mm^2.		Most modern [[microscope]]s, have an eye piece diameter of 22 mm. Therefore, the field diameter at 40 X is approximately 22 mm / 40 X ~= 0.55 mm and the field of view is pi/4(0.55 mm)^2 = 0.2376 mm^2.

	==Pathology reports==		==Pathology reports==

Sarah: /* Factors to consider */

2015-04-03T06:15:07Z

Factors to consider

← Older revision		Revision as of 06:15, 3 April 2015
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	#Cytoplasm - abundance (scant, moderate, abundant).		#Cytoplasm - abundance (scant, moderate, abundant).
	#*Eosinophilic cytoplasm disfavours lymphoma.		#*Eosinophilic cytoplasm disfavours lymphoma.
			#*Oncocytic - possessing copious eosinophilic granular cytoplasm.
			#**Benign lesions composed of oncocytes - oncocytoma
			#**Oncocytic metaplasia (alteration of cytoplasm) can effect all or a part of a lesion.
			#**Oncocytic neoplasms are common in the kidneys, thyroid and salivary glands.
			#**Oncocytic change increases with age
			#**May represent senescent accumulation of mitochondria in secretory epithelial.
	#Chromatin - coarseness (fine, granular).		#Chromatin - coarseness (fine, granular).
	#Nucleoli - number (absent, present, multiple).		#Nucleoli - number (absent, present, multiple).

Michael: /* Granulomas */ split out

2015-03-01T03:07:52Z

Granulomas: split out

← Older revision		Revision as of 03:07, 1 March 2015
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	==Granulomas==		==Granulomas==
	*Granulomas can be elusive to the novice.		{{Main\|Granuloma}}
	*Plural of ''granuloma'' was ''granulomata''; ''granulomas'' (an anglicized version) is, however, now generally accepted.

	~~===Definition of granuloma===~~
	*Many definitions exist.
	*The term is used rather loosely by clinicans.
	**Radiologists occasionally call small lung nodules "granulomas".

	~~====Strict pathologic definition====~~
	~~Robbins definition:~~
	*Chronic inflammatory reaction characterized by the focal accumulation of activated macrophages, often with an epithelioid appearance.<ref name=Ref_PBoD82>{{~~Ref PBoD\|82}}</ref>~~
	**"Epithelioid" cells = cells whose morphology resembles that of epithelial cells; the cells appear to adhere to one another.

	~~Adams definition - it's short & sweet:~~
	*A compact collection of macrophages.<ref name=pmid937513>{{cite journal \|author=Adams DO \|title=The granulomatous inflammatory response. A review. \|journal=American Journal of Pathology \|volume=84 \|issue=1 \|pages=164–191 \|year=1976 \|pmid=937513 \|doi= \|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032357/?tool=pubmed}}</ref>
	**The macrophages must form a small ball/cluster of cells, i.e. touch one another.

	~~Other pathologic definitions include the presence of:<ref name=pmid937513/>~~
	*Plasma cells.
	*Lymphocytes.
	*Epithelioid macrophages.

	~~Notes:~~
	*The textbook answer for what is a granuloma is: "A collection of epithelioid macrophages."
	**Granulomas are often associated with lymphocytes.

	~~===Features that assist one in finding granulomas===~~
	~~#Collection of cells that have abundant bubbly cytoplasm - '''most useful feature'''.~~
	~~#'''Multinucleated [[giant cells]]''' - these are easy to identify if you've seen some before.~~
	~~#*Individual/singular multinucleated giant cells are not diagnostic of a granuloma... but should raise one's suspicion of one being present.~~
	~~#Necrosis - too much pink (on H&E stained sections).~~

	~~Notes:~~
	*Small round collection of lymphocytes - without a capsule (as seen in lymph nodes).
	**If there are no macrophages... it's a ''lymphoid nodule''.

	~~Images:~~
	~~<gallery>~~
	~~Image:Granuloma_20x.jpg \|Granulomas showing abundant bubbly cytoplasm. (WC)~~
	~~Image:Asteroid_body_intermed_mag.jpg \|Granulomas with multinucleated giant cells in sarcoidosis. (WC)~~
	~~Image:Necrogran10x.jpg~~\|Granuloma ~~with necrosis. (WC)~~
	~~</gallery>~~
	~~====As a list====~~
	~~Features:<ref>Santos, G. 26 January 2010.</ref>~~
	~~#Foamy/bubbly cytoplasm, abundant - '''low power'''.~~
	~~#Epithelioid morphology - cell borders ''near'' indistinct - '''key feature'''.~~
	~~#"Footprint" pattern nuclei/bean-shaped nuclei - '''key feature'''.~~
	~~#*Macrophages usu. have an ovoid nucleus.~~
	~~#+/-Nucleoli, small.~~
	~~#+/-Fibrosis.~~
	~~#+/-Palisading at edge.~~

	~~====DDx====~~
	*Reactive germinal centre - especially if there are abundant surrounding lymphocytes.<ref name=Ref_GLP170>{{Ref GLP\|170}}</ref>

	~~===Classification of granuloma===~~
	~~====Histologic classification====~~
	~~#Necrosing (also ''caseating'').~~
	~~#*More likely to be infectious.~~
	~~#*Examples: [[Tuberculosis]] (TB).~~
	~~#Non-necrosing.~~
	~~#*Less likely to be infectious.~~
	~~#*Examples: Crohn's disease, sarcoidosis, drug reaction.~~

	~~Whether necrosis is present in a granuloma is affected by the immune function, e.g. a [[HIV]]/AIDS patient may have non-necrosing granulomata due to TB.~~

	~~Notes:~~
	*A few people differentiate between ''caseating'' (fragments of recognizable tissue) and ''necrosing'' (dead debris only).<ref name=pmid17257125>{{Cite journal \| last1 = El-Zammar \| first1 = OA. \| last2 = Katzenstein \| first2 = AL. \| title = Pathological diagnosis of granulomatous lung disease: a review. \| journal = Histopathology \| volume = 50 \| issue = 3 \| pages = 289-310 \| month = Feb \| year = 2007 \| doi = 10.1111/j.1365-2559.2006.02546.x \| PMID = 17257125 }}</ref>
	*Infectious non-necrosing infections: [[Mycobacterium avium complex]] (MAC), [[cryptococcus]], infections in immunosuppressed individuals.<ref name=pmid17257125/>

	~~====Etiologic classification====~~
	~~#Infectious, e.g. [[tuberculosis]], [[MAC]], [[leprosy]], [[syphilis]], [[cat-scratch disease]], schistosomiasis,<ref name=Ref_PCPBoD8_47>{{Ref PCPBoD8\|47}}</ref> fungal infection.~~
	#Neoplastic, e.g. [[seminoma]], Lennert lymphoma,<ref name=pmid19775391>{{Cite journal \| last1 = Summers \| first1 = TA. \| last2 = Rush \| first2 = W. \| last3 = Aguilera \| first3 = N. \| last4 = Lupton \| first4 = G. \| title = Cutaneous involvement in the lymphoepithelioid variant of peripheral T-cell lymphoma, unspecified (Lennert lymphoma). Report of a case and review of the literature. \| journal = J Cutan Pathol \| volume = 36 Suppl 1 \| issue = \| pages = 25-30 \| month = Oct \| year = 2009 \| doi = 10.1111/j.1600-0560.2008.01203.x \| PMID = 19775391 }}</ref> ruptured ovarian teratoma.<ref name=pmid15526210>{{Cite journal \| last1 = Phupong \| first1 = V. \| last2 = Sueblinvong \| first2 = T. \| last3 = Triratanachat \| first3 = S. \| title = Ovarian teratoma with diffused peritoneal reactions mimicking advanced ovarian malignancy. \| journal = Arch Gynecol Obstet \| volume = 270 \| issue = 3 \| pages = 189-91 \| month = Nov \| year = 2004 \| doi = 10.1007/s00404-003-0479-8 \| PMID = 15526210 }}</ref>
	~~#Autoimmune/inflammatory, e.g. [[Wegener's granulomatosis]], [[Churg-Strauss syndrome]].~~
	~~#Allergic, e.g. [[hypersensitivity pneumonitis]].~~
	~~#Foreign body, e.g. [[pulmonary talcosis]], silicosis, berylliosis,<ref name=Ref_PCPBoD8_47>{{Ref PCPBoD8\|47}}</ref> [[suture material]].~~
	~~#Drug reaction.~~
	~~#Idiopathic, e.g. [[sarcoidosis]].~~

	~~Notes:~~
	*Memory device: ''DNF AAII'' = drug reaction, neoplasm, foreign body, allergy, autoimmune, idiopathic, infection.
	*A long [[DDx]] for granulomas is complied by ''James''.<ref name=pmid10908370>{{Cite journal \| last1 = James \| first1 = DG. \| title = A clinicopathological classification of granulomatous disorders. \| journal = Postgrad Med J \| volume = 76 \| issue = 898 \| pages = 457-65 \| month = Aug \| year = 2000 \| doi = \| PMID = 10908370 }}</ref>

	~~===Lung granulomata===~~
	~~There are many causes.<ref name=pmid17257125/>~~

	~~Infectious:~~
	*Myocbacterial: [[Tuberculosis]], [[MAC]], other.
	*Fungal: [[Histoplasmosis]], [[Cryptococcosis]], [[Blastomycosis]], [[Coccidioidomycosis]].
	*[[Aspiration pneumonia]].
	~~Non-infectious:~~
	*Pneumoconioses/[[hypersensitivity pneumonitis]]: Talcosis, Berylliosis.
	~~Idiopathic/autoimmune:~~
	*[[Sarcoidosis]].
	*[[Wegener's granulomatosis]].
	*[[Churg-Strauss disease]].
	*[[Rheumatoid nodules]].

	~~===Special granulomas===~~
	~~====Fibrin ring granuloma====~~
	*Classically associated with ''[[Q fever]]''.
	**DDx:<ref name=pmid11881318>{{cite journal \|author=Tjwa M, De Hertogh G, Neuville B, Roskams T, Nevens F, Van Steenbergen W \|title=Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature \|journal=Acta Clin Belg \|volume=56 \|issue=6 \|pages=341–8 \|year=2001 \|pmid=11881318 \|doi= \|url=}}</ref> infections (Coxiella burnetii (causes [[Q fever]]), [[CMV]], [[EBV]] + others), drug reaction, malignancy (e.g. Hodgkin lymphoma<ref name=pmid8514044>{{cite journal \|author=de Bayser L, Roblot P, Ramassamy A, Silvain C, Levillain P, Becq-Giraudon B \|title=Hepatic fibrin-ring granulomas in giant cell arteritis \|journal=Gastroenterology \|volume=105 \|issue=1 \|pages=272–3 \|year=1993 \|month=July \|pmid=8514044 \|doi= \|url=}}</ref>).
	*Appearance:
	**Epithelioid macrophages (i.e. a granuloma) surrounding a fibrin ring with a clear (lipid-filled) vacuole at its center.
	***Images:
	****[http://en.gooword.com/picture/864449/ FRG (gooword.com)].
	~~====Naked granuloma====~~
	*Minimal (lymphoid) inflammation.
	**Classically [[sarcoidosis]] <ref name=pmid18948765>{{Cite journal \| last1 = Brinster \| first1 = NK. \| title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). \| journal = Adv Anat Pathol \| volume = 15 \| issue = 6 \| pages = 350-69 \| month = Nov \| year = 2008 \| doi = 10.1097/PAP.0b013e31818b1ac6 \| PMID = 18948765 }}</ref><ref name=pmid24138972>{{Cite journal \| last1 = Noiles \| first1 = K. \| last2 = Beleznay \| first2 = K. \| last3 = Crawford \| first3 = RI. \| last4 = Au \| first4 = S. \| title = Sarcoidosis can present with necrotizing granulomas histologically: two cases of ulcerated sarcoidosis and review of the literature. \| journal = J Cutan Med Surg \| volume = 17 \| issue = 6 \| pages = 377-83 \| month = \| year = \| doi = \| PMID = 24138972 }}~~</ref> - DDx large.~~

	==Common morphologic problems==		==Common morphologic problems==

Michael: /* Lab talk */

2015-01-20T17:50:59Z

Lab talk

← Older revision		Revision as of 17:50, 20 January 2015
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	==Lab talk==		==Lab talk==
			{{Main\|Cutting}}
	Tissue cutting terms - these often vary from lab-to-lab:<ref>URL: [http://www.mailman.srv.ualberta.ca/pipermail/patho-l/2002-July/016955.html http://www.mailman.srv.ualberta.ca/pipermail/patho-l/2002-July/016955.html]. Accessed on: 18 October 2011.</ref>		Tissue cutting terms - these often vary from lab-to-lab:<ref>URL: [http://www.mailman.srv.ualberta.ca/pipermail/patho-l/2002-July/016955.html http://www.mailman.srv.ualberta.ca/pipermail/patho-l/2002-July/016955.html]. Accessed on: 18 October 2011.</ref>
	*Recut = cut off the top of the block.		*Recut = cut off the top of the block.

Laura: /* Strict pathologic definition */

2014-11-19T22:41:32Z

Strict pathologic definition

← Older revision		Revision as of 22:41, 19 November 2014
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	Notes:		Notes:
	*The textbook answer for what is a granuloma is: "A collection of ~~epitheliod~~ macrophages."		*The textbook answer for what is a granuloma is: "A collection of epithelioid macrophages."
	**Granulomas are often associated with lymphocytes.		**Granulomas are often associated with lymphocytes.

Michael: /* Three questions */

2014-09-13T16:50:36Z

Three questions

← Older revision		Revision as of 16:50, 13 September 2014
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	Pathology can be boiled down to:		Pathology can be boiled down to:
	#What is it?		#What is it?
			#*Biopsies.
	#Did I get it all?		#Did I get it all?
	#*Resections.		#*Resections.

Michael: /* Three questions */

2014-09-13T16:46:21Z

Three questions

← Older revision		Revision as of 16:46, 13 September 2014
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	#What is it?		#What is it?
	#Did I get it all?		#Did I get it all?
			#*Resections.
	#Did I get the right thing?		#Did I get the right thing?
			#*Most other things.

	==Terms==		==Terms==

← Older revision		Revision as of 02:49, 31 October 2015
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	*''Argyrophilic'' means has an affinity for silver<ref>URL: [http://www.merriam-webster.com/medical/argyrophilic http://www.merriam-webster.com/medical/argyrophilic]. Accessed on: 29 August 2011.</ref><ref>URL: [http://en.wiktionary.org/wiki/argyrophilic http://en.wiktionary.org/wiki/argyrophilic]. Accessed on: 29 August 2011.</ref>/loves silver/stains with silver.		*''Argyrophilic'' means has an affinity for silver<ref>URL: [http://www.merriam-webster.com/medical/argyrophilic http://www.merriam-webster.com/medical/argyrophilic]. Accessed on: 29 August 2011.</ref><ref>URL: [http://en.wiktionary.org/wiki/argyrophilic http://en.wiktionary.org/wiki/argyrophilic]. Accessed on: 29 August 2011.</ref>/loves silver/stains with silver.
	===Morphologic patterns===		===Morphologic patterns===
	{\| ~~class="wikitable sortable" style="margin-left:auto;margin-right:auto"~~		{{Main\|Morphologic patterns}}
	~~! Name of pattern~~
	~~! Meaning~~
	~~! DDx (incomplete/abbrev. list)~~
	~~! Image~~
	\|-
	~~\| Hobnail~~
	~~\| basement membrane area < area exposed to luminal surface~~
	~~\| [[angiosarcoma]], clear cell carcinoma~~
	~~\| [[Image:Epithelioid_angiosarcoma_-_very_high_mag.jpg \|thumb\|center\|150px\| [[Angiosarcoma]] - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Storiform~~
	\| spiral appearance ''or'' cartwhell pattern<ref>Storiform. dictionary.com. URL: [http://dictionary.reference.com/browse/storiform http://dictionary.reference.com/browse/storiform]. Accessed on: April 24, 2009.</ref>
	~~\| [[solitary fibrous tumour]], [[DFSP]], [[dermatofibroma]], [[UPS]]~~
	~~\| [[Image:Storiform_pattern_-_very_high_mag.jpg \| thumb\| center\|150px\| [[DFSP]] - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Fascicular~~
	~~\| the long axis of the (spindle) cells are perpendicular to one another in adjacent bundles of cells~~
	~~\| [[leiomyoma]], [[leiomyosarcoma]]~~
	~~\| [[Image:Cutaneous_leiomyosarcoma_-_very_high_mag.jpg\| thumb \| center \| 150px \| [[Leiomyosarcoma]] - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Plexiform~~
	~~\| web-like formation<ref>URL: [http://www.mondofacto.com/facts/dictionary?plexiform http://www.mondofacto.com/facts/dictionary?plexiform]. Accessed on: March 9, 2010.</ref>~~
	~~\| [[plexiform neurofibroma]], [[MPNST]], plexiform lesion of [[pulmonary hypertension]]~~
	~~\| [http://www.flickr.com/photos/bc_the_path/1715728630/ plexiform lesion of Pulm. HTn (flickr.com)]~~
	\|-
	~~\| Cribriform~~
	~~\| pierced with small holes<ref>URL: [http://dictionary.reference.com/browse/cribriform http://dictionary.reference.com/browse/cribriform]. Accessed on: 8 August 2011.</ref>~~
	~~\| cribriform [[DCIS]], cribriform [[HGPIN]], cribriforming in a [[tubular adenoma of the gastrointestinal tract\|tubular adenoma]] with high-grade dysplasia, endometrioid endometrial carcinoma~~
	~~\| [[Image:Atypical_ductal_hyperplasia_-_very_high_mag.jpg\|thumb\|center\|150px\|Cribriform architecure ([[ADH]]) - very high mag. (WC/Nephron)]]~~
	\|-
	~~\| Solid ''or'' Sheeting~~
	~~\| no architecture - back-to-back cells with no pattern apparent / no spaces between cells~~
	~~\| solid DCIS, poorly-differentiated malignancy (carcinoma, sarcoma, lymphoma)~~
	~~\| [[Image:Merkel_cell_carcinoma_-_high_mag.jpg\|thumb\|center\|150px\|Sheeting in a [[Merkel cell carcinoma]] - high mag. (WC/Nephron)]]~~
	\|-
	~~\| Micropapillary~~
	\| nipple like projections without a fibrovascular core (papillary = nipple-like<ref>URL: [http://dictionary.reference.com/browse/papillary http://dictionary.reference.com/browse/papillary]. Accessed on: 8 August 2011.</ref>)
	~~\| micropapillary [[DCIS]], micropapillary [[HGPIN]]~~
	~~\| [[File:Invasive_micropapillary_carcinoma_of_the_breast.jpg\|thumb\|center\|150px\|Micropapillary carcinoma. (WC)]]~~
	\|-
	~~\| Papillary~~
	~~\| nipple-like projection with a fibrovascular core~~
	~~\| [[papillary thyroid carcinoma]]~~
	~~\| [[Image:Papillary_renal_cell_carcinoma_high_mag.jpg\| thumb\|center\|150px\|[[Papillary RCC]] - high mag. (WC/Nephron)]]~~
	\|-
	~~\| Flat~~
	~~\| board-like, does not have a projection above the surface~~
	~~\| flat DCIS~~
	\| [http://www.breastpathology.info/Sloane/Images/dcis/flat1-400.jpg flat DCIS 1 (breastpathology.info)],<ref name=sloane/> [http://www.breastpathology.info/Sloane/Images/dcis/flat2-400.jpg flat DCIS 2 (breastpathology.info)]<ref name=sloane>URL: [http://www.breastpathology.info/Sloane/dcis.html http://www.breastpathology.info/Sloane/dcis.html]. Accessed on: 8 August 2011.</ref>
	\|-
	~~\| Herring bone~~
	~~\| like herring bone (technique) for climbing a hill in cross country skiing; books on a shelf, where they have partially fallen over -- on the one shelf to the left and the one below to the right~~
	~~\| [[fibrosarcoma]], [[synovial sarcoma]], [[MPNST]]~~
	~~\| [[Image:Malignant_peripheral_nerve_sheath_tumour_-_high_mag.jpg\|thumb\|center\|150px\| [[MPNST]] - high mag.(WC/Nephron)]]~~
	\|-
	~~\| [[Trabecular]] ''or'' cords~~
	\| trabecula = ''little beam''<ref>URL: [http://dictionary.reference.com/browse/trabecula http://dictionary.reference.com/browse/trabecula]. Accessed on: 26 December 2010.</ref>; quasi-linear arrangement of cells
	~~\| normal liver lobule, [[Sertoli cell tumour]]~~
	~~\| [[Image:Papillary thyroid carcinoma tall cell var high mag.jpg\|thumb\|center\|150px\|[[PTC]] tall cell variant - high mag. (WC/Nephron)]]~~
	\|-
	~~\| Nested (nesting)~~
	~~\| islands of cells with a circular outline~~
	~~\| neuroendocrine tumours~~
	~~\| [[Image:Small_intestine_neuroendocrine_tumour_high_mag_cropped.jpg \|thumb\|center\|150px\|[[Neuroendocrine tumour]] - low mag. (WC/Nephron)]]~~
	\|-
	~~\| Biphasic / multiple patterns~~
	~~\| multiple~~ patterns ~~or cell types; e.g. spindle cells and epithelioid cells~~
	~~\| [[synovial sarcoma]], [[malignant melanoma]], [[pleomorphic adenoma]], [[angiomyolipoma]], [[chondroid syringoma]]~~
	~~\| [[Image:Desmoplastic_small_round_cell_tumour_-_high_mag.jpg \|thumb\|center\|150px\| [[DSRCT]] - high mag. (WC/Nephron)]]~~
	\|}

	===Nuclear destruction words===		===Nuclear destruction words===