Atypical fibroxanthoma - Revision history

Michael at 14:51, 4 August 2022

2022-08-04T14:51:17Z

← Older revision		Revision as of 14:51, 4 August 2022
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	Features:<ref name=Ref_Derm521>{{Ref Derm\|521}}</ref>		Features:<ref name=Ref_Derm521>{{Ref Derm\|521}}</ref>
	*S100 -ve (done to r/o melanoma).		*S100 -ve (done to r/o melanoma).
	*CK34betaE12 -ve.		*[[CK34betaE12]] -ve.
	*p63 -ve (done to exclude [[squamous cell carcinoma of the skin\|SCC]]).		*[[p63]] -ve (done to exclude [[squamous cell carcinoma of the skin\|SCC]]).
	**Scant staining not considered +ve.		**Scant staining not considered +ve.
	*Desmin -ve (done to r/o leiomyosarcoma).		*Desmin -ve (done to r/o leiomyosarcoma).

Mitchell: /* Images */ added a case of an important, albeit rare, diagnosis that can mimic AFX

2017-04-27T14:42:29Z

Images: added a case of an important, albeit rare, diagnosis that can mimic AFX

← Older revision		Revision as of 14:42, 27 April 2017
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	</gallery>		</gallery>
	www:		www:
	*[http://dermatology.cdlib.org/141/case_reports/afx/1.jpg AFX (cdlib.org)].<ref name=pmid18319023>{{Cite journal \| last1 = Vandergriff \| first1 = TW. \| last2 = Reed \| first2 = JA. \| last3 = Orengo \| first3 = IF. \| title = An unusual presentation of atypical fibroxanthoma. \| journal = Dermatol Online J \| volume = 14 \| issue = 1 \| pages = 6 \| month = \| year = 2008 \| doi = \| PMID = 18319023 }}</ref>		*[http://dermatology.cdlib.org/141/case_reports/afx/1.jpg AFX (cdlib.org)].<ref name=pmid18319023>{{Cite journal \| last1 = Vandergriff \| first1 = TW. \| last2 = Reed \| first2 = JA. \| last3 = Orengo \| first3 = IF. \| title = An unusual presentation of atypical fibroxanthoma. \| journal = Dermatol Online J \| volume = 14 \| issue = 1 \| pages = 6 \| month = \| year = 2008 \| doi = \| PMID = 18319023 }}</ref>

			A markedly atypical lesion of far less worrisome significance is the pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis).
			[[File:DP27AP17 sl1.png\| Pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis).]]
			[[File:DP27AP17 sl2.png\| Pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis).]]
			[[File:DP27AP17 sl3.png\| Pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis).]]
			[[File:DP27AP17 sl4.png\| Pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis).]]
			[[File:DP27AP17 sl5.png\| Pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis).]]
			[[File:DP27AP17 sl6.png\| Pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis).]]
			<br>
			Pleomorphic hyalinizing angioectatic tumor of soft parts (subcutis). A. The key distinction is at low power, wherein cluters of thin-walled, indented (ectatic) blood vessels are seen. B. The ectatic vessels have a thin endothelial lining and a thick subjacent rim of amorphous eosinophilia. Note the multinucleated cells in the stroma. C. Hyaline material extends beyond vessels to entrap stromal cells. D. Cellularity in part raises the possibility of a sarcoma. E. High power further raises the suspicion of malignancy, given the aberrant nuclei with prominent nucleoli. F. Reassurance occurs because 1) there are virtually no mitoses, 2) there is no necrosis, and 3) there are readily identifiable nuclear inclusions as seen in these tumor cells.

	==IHC==		==IHC==

Michael at 20:47, 5 May 2016

2016-05-05T20:47:10Z

← Older revision		Revision as of 20:47, 5 May 2016
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	A panel:		A panel:
	*Vimentin, SMA, CD68, CK18, EMA, CAM5.2, CK34betaE12, CK5/6, p63, desmin, CD99, CD10, S100, CD34.		*Vimentin, SMA, CD68, CK18, [[EMA]], [[CAM5.2]], CK34betaE12, [[CK5/6]], [[p63]], desmin, CD99, CD10, S100, CD34.

	==Sign out==		==Sign out==

Michael: /* IHC */

2015-10-14T18:01:41Z

IHC

← Older revision		Revision as of 18:01, 14 October 2015
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	**Scant staining not considered +ve.		**Scant staining not considered +ve.
	*Desmin -ve (done to r/o leiomyosarcoma).		*Desmin -ve (done to r/o leiomyosarcoma).
			*[[CD99]] +ve.<ref name=pmid11789717>{{Cite journal \| last1 = Monteagudo \| first1 = C. \| last2 = Calduch \| first2 = L. \| last3 = Navarro \| first3 = S. \| last4 = Joan-Figueroa \| first4 = A. \| last5 = Llombart-Bosch \| first5 = A. \| title = CD99 immunoreactivity in atypical fibroxanthoma: a common feature of diagnostic value. \| journal = Am J Clin Pathol \| volume = 117 \| issue = 1 \| pages = 126-31 \| month = Jan \| year = 2002 \| doi = 10.1309/2EXB-70CW-3U6P-VQ6H \| PMID = 11789717 }}</ref>
			**Usually +ve in [[melanoma]]... but negative in [[squamous carcinoma]].

	Others:		Others:

Michael: /* IHC */

2015-10-14T17:49:08Z

IHC

← Older revision		Revision as of 17:49, 14 October 2015
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	New ''et al.'' suggests:<ref name=pmid20713774>{{Cite journal \| last1 = New \| first1 = D. \| last2 = Bahrami \| first2 = S. \| last3 = Malone \| first3 = J. \| last4 = Callen \| first4 = JP. \| title = Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature. \| journal = Arch Dermatol \| volume = 146 \| issue = 12 \| pages = 1399-404 \| month = Dec \| year = 2010 \| doi = 10.1001/archdermatol.2010.206 \| PMID = 20713774 }}</ref>		New ''et al.'' suggests:<ref name=pmid20713774>{{Cite journal \| last1 = New \| first1 = D. \| last2 = Bahrami \| first2 = S. \| last3 = Malone \| first3 = J. \| last4 = Callen \| first4 = JP. \| title = Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature. \| journal = Arch Dermatol \| volume = 146 \| issue = 12 \| pages = 1399-404 \| month = Dec \| year = 2010 \| doi = 10.1001/archdermatol.2010.206 \| PMID = 20713774 }}</ref>
	*Vimentin, SMA, CD68, cytokeratins, p63, desmin, CD99, CD10, ~~S-100~~, CD117, LN-2, procollagen I.		*Vimentin, SMA, CD68, cytokeratins, p63, desmin, CD99, CD10, S100, CD117, LN-2, procollagen I.

	A panel:		A panel:

Michael: /* IHC */

2015-10-14T17:48:41Z

IHC

← Older revision		Revision as of 17:48, 14 October 2015
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	**Scant staining not considered +ve.		**Scant staining not considered +ve.
	*Desmin -ve (done to r/o leiomyosarcoma).		*Desmin -ve (done to r/o leiomyosarcoma).

			Others:
			*Vimentin +ve.
			*SMA +ve.{{fact}}

			New ''et al.'' suggests:<ref name=pmid20713774>{{Cite journal \| last1 = New \| first1 = D. \| last2 = Bahrami \| first2 = S. \| last3 = Malone \| first3 = J. \| last4 = Callen \| first4 = JP. \| title = Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature. \| journal = Arch Dermatol \| volume = 146 \| issue = 12 \| pages = 1399-404 \| month = Dec \| year = 2010 \| doi = 10.1001/archdermatol.2010.206 \| PMID = 20713774 }}</ref>
			*Vimentin, SMA, CD68, cytokeratins, p63, desmin, CD99, CD10, S-100, CD117, LN-2, procollagen I.

			A panel:
			*Vimentin, SMA, CD68, CK18, EMA, CAM5.2, CK34betaE12, CK5/6, p63, desmin, CD99, CD10, S100, CD34.

	==Sign out==		==Sign out==

Michael: +images

2014-02-04T03:38:24Z

+images

← Older revision		Revision as of 03:38, 4 February 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = SkinTumors-P9280874.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Atypical fibroxanthoma. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = dermal lesion with marked nuclear atypia, mitoses, mulitnucleated cells, cell have foamy cytoplasm		\| Micro = dermal lesion with marked nuclear atypia, mitoses, mulitnucleated cells, cell have foamy cytoplasm
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	*No Grenz zone. (???)		*No Grenz zone. (???)

	Image:		===Images===
			<gallery>
			Image: SkinTumors-P9280873.jpg \| AFX. (WC)
			Image: SkinTumors-P9280874.jpg \| AFX. (WC)
			Image: SkinTumors-P9280875.jpg \| AFX. (WC)
			</gallery>
			www:
	*[http://dermatology.cdlib.org/141/case_reports/afx/1.jpg AFX (cdlib.org)].<ref name=pmid18319023>{{Cite journal \| last1 = Vandergriff \| first1 = TW. \| last2 = Reed \| first2 = JA. \| last3 = Orengo \| first3 = IF. \| title = An unusual presentation of atypical fibroxanthoma. \| journal = Dermatol Online J \| volume = 14 \| issue = 1 \| pages = 6 \| month = \| year = 2008 \| doi = \| PMID = 18319023 }}</ref>		*[http://dermatology.cdlib.org/141/case_reports/afx/1.jpg AFX (cdlib.org)].<ref name=pmid18319023>{{Cite journal \| last1 = Vandergriff \| first1 = TW. \| last2 = Reed \| first2 = JA. \| last3 = Orengo \| first3 = IF. \| title = An unusual presentation of atypical fibroxanthoma. \| journal = Dermatol Online J \| volume = 14 \| issue = 1 \| pages = 6 \| month = \| year = 2008 \| doi = \| PMID = 18319023 }}</ref>

Michael at 02:56, 22 December 2013

2013-12-22T02:56:46Z

← Older revision		Revision as of 02:56, 22 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro = dermal lesion with marked nuclear atypia, mitoses, mulitnucleated cells, cell have foamy cytoplasm
			\| Subtypes =
			\| LMDDx = [[malignant melanoma]], [[pleomorphic undifferentiated sarcoma]], [[leiomyosarcoma]], sarcomatoid [[squamous carcinoma]]
			\| Stains =
			\| IHC = S-100 -ve, CK34betaE12 -ve, p63 -ve, desmin -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[skin]] - see [[skin tumours]], usu. head & neck
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = rapid growth, elderly
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good
			\| Other =
			\| ClinDDx = malignant [[skin tumours]]
			\| Tx = complete excision
			}}
	'''Atypical fibroxanthoma''', abbreviated '''AFX''', is poorly differentiated [[skin tumour]] with likeness to [[undifferentiated pleomorphic sarcoma]].		'''Atypical fibroxanthoma''', abbreviated '''AFX''', is poorly differentiated [[skin tumour]] with likeness to [[undifferentiated pleomorphic sarcoma]].

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	DDx:		DDx:
	*[[~~Melanoma~~]].		*[[Malignant melanoma]].
	*[[Pleomorphic undifferentiated sarcoma]] (MFH) - deeper than the dermis.		*[[Pleomorphic undifferentiated sarcoma]] (MFH) - deeper than the dermis.
	*[[Leiomyosarcoma]].		*[[Leiomyosarcoma]].
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	Features:<ref name=Ref_Derm521>{{Ref Derm\|521}}</ref>		Features:<ref name=Ref_Derm521>{{Ref Derm\|521}}</ref>
	*S100 -ve (done to r/o melanoma).		*S100 -ve (done to r/o melanoma).
	*~~34betaE12~~ -ve.		*CK34betaE12 -ve.
	*p63 -ve (done to exclude SCC)		*p63 -ve (done to exclude [[squamous cell carcinoma of the skin\|SCC]]).
	**Scant staining not considered +ve.		**Scant staining not considered +ve.
	*Desmin -ve (done to r/o leiomyosarcoma).		*Desmin -ve (done to r/o leiomyosarcoma).

Michael: split out

2013-12-22T02:51:26Z

split out

← Older revision		Revision as of 02:51, 22 December 2013
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	~~#redirect~~ [[Dermatologic neoplasms~~#Atypical_fibroxanthoma~~]]		'''Atypical fibroxanthoma''', abbreviated '''AFX''', is poorly differentiated [[skin tumour]] with likeness to [[undifferentiated pleomorphic sarcoma]].

			==General==
			*Typically head & neck region.<ref>URL: [http://emedicine.medscape.com/article/1056204-overview http://emedicine.medscape.com/article/1056204-overview]. Accessed on 2 September 2011.</ref>
			*Thought to be related to [[pleomorphic undifferentiated sarcoma]];<ref name=pmid21664889>{{Cite journal \| last1 = Withers \| first1 = AH. \| last2 = Brougham \| first2 = ND. \| last3 = Barber \| first3 = RM. \| last4 = Tan \| first4 = ST. \| title = Atypical fibroxanthoma and malignant fibrous histiocytoma. \| journal = J Plast Reconstr Aesthet Surg \| volume = \| issue = \| pages = \| month = Jun \| year = 2011 \| doi = 10.1016/j.bjps.2011.05.004 \| PMID = 21664889 }}</ref><ref name=pmid23319144>{{Cite journal \| last1 = Tchernev \| first1 = G. \| last2 = Tronnier \| first2 = M. \| last3 = Ananiev \| first3 = J. \| last4 = Taneva \| first4 = T. \| last5 = Patterson \| first5 = JW. \| last6 = Gulubova \| first6 = M. \| last7 = Trafeli \| first7 = JP. \| last8 = Gegova \| first8 = A. \| last9 = Harrell \| first9 = M. \| title = Atypical fibroxanthoma-a diagnosis of exclusion! \| journal = Wien Med Wochenschr \| volume = 163 \| issue = 15-16 \| pages = 380-386 \| month = Aug \| year = 2013 \| doi = 10.1007/s10354-012-0173-1 \| PMID = 23319144 }}</ref> some say it is the same thing.<ref name=danny>Ghazarian, Danny; 16 September 2011.</ref>
			*Usually benign.
			**May metastasize - case report-type of occurrence.<ref>{{Cite journal \| last1 = New \| first1 = D. \| last2 = Bahrami \| first2 = S. \| last3 = Malone \| first3 = J. \| last4 = Callen \| first4 = JP. \| title = Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature. \| journal = Arch Dermatol \| volume = 146 \| issue = 12 \| pages = 1399-404 \| month = Dec \| year = 2010 \| doi = 10.1001/archdermatol.2010.206 \| PMID = 20713774 \| URL = http://archderm.jamanetwork.com/article.aspx?articleid=422416 }}</ref>

			Clinical:
			*Rapid growth.
			*Elderly.
			*Good prognosis.<ref name=pmid20526171>{{Cite journal \| last1 = Beer \| first1 = TW. \| last2 = Drury \| first2 = P. \| last3 = Heenan \| first3 = PJ. \| title = Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases. \| journal = Am J Dermatopathol \| volume = 32 \| issue = 6 \| pages = 533-40 \| month = Aug \| year = 2010 \| doi = 10.1097/DAD.0b013e3181c80b97 \| PMID = 20526171 }}</ref>

			==Microscopic==
			Features:<ref name=Ref_Derm521>{{Ref Derm\|521}}</ref>
			*Dermal lesion - '''key point'''.
			*Marked nuclear atypia.
			*Mitoses.
			*Mulitnucleated cells.
			*Foamy cytoplasm - '''key feature'''.

			DDx:
			*[[Melanoma]].
			*[[Pleomorphic undifferentiated sarcoma]] (MFH) - deeper than the dermis.
			*[[Leiomyosarcoma]].
			*Sarcomatoid [[squamous carcinoma]].

			Notes:
			*No Grenz zone. (???)

			Image:
			*[http://dermatology.cdlib.org/141/case_reports/afx/1.jpg AFX (cdlib.org)].<ref name=pmid18319023>{{Cite journal \| last1 = Vandergriff \| first1 = TW. \| last2 = Reed \| first2 = JA. \| last3 = Orengo \| first3 = IF. \| title = An unusual presentation of atypical fibroxanthoma. \| journal = Dermatol Online J \| volume = 14 \| issue = 1 \| pages = 6 \| month = \| year = 2008 \| doi = \| PMID = 18319023 }}</ref>

			==IHC==
			Features:<ref name=Ref_Derm521>{{Ref Derm\|521}}</ref>
			*S100 -ve (done to r/o melanoma).
			*34betaE12 -ve.
			*p63 -ve (done to exclude SCC)
			**Scant staining not considered +ve.
			*Desmin -ve (done to r/o leiomyosarcoma).

			==Sign out==
			===Incompletely excised===
			<pre>
			SKIN LESION, MID BACK, SHAVE BIOPSY:
			- ATYPICAL SPINDLE CELL NEOPLASM, SEE MICRO AND COMMENT.

			COMMENT:
			The diagnosis of atypical fibroxanthoma (AFX) is favoured. The main differential
			diagnosis is pleomorphic undifferentiated sarcoma.

			The extent of the lesion cannot be determined, as it is present at the deep margin.

			This lesion should be re-excised, as it could represent an aggressive malignancy.
			</pre>

			==See also==
			*[[Dermatologic neoplasms]].
			*[[Undifferentiated pleomorphic sarcoma]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Dermatologic neoplasms]]

Michael: +cat.

2011-10-18T03:24:05Z

+cat.

← Older revision		Revision as of 03:24, 18 October 2011
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	#redirect [[Dermatologic neoplasms#Atypical_fibroxanthoma]]		#redirect [[Dermatologic neoplasms#Atypical_fibroxanthoma]]

			[[Category:Diagnosis]]