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Difference between revisions of "Zoon vulvitis"
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**"Lozenge"-shaped (diamond-like shape). | **"Lozenge"-shaped (diamond-like shape). | ||
*Abundant plasma cells - esp. superficial dermis. | *Abundant plasma cells - esp. superficial dermis. | ||
**Keep in mind that plasma cells are a common component of mucosal infiltrates, much more so than for skin. | |||
**A plasma cell component has to be relatively prominent to be relevant in this location (the same can be said for eosinophils). | |||
*Hemosiderin deposits.<ref name=pmid6833541>{{Cite journal | last1 = Davis | first1 = J. | last2 = Shapiro | first2 = L. | last3 = Baral | first3 = J. | title = Vulvitis circumscripta plasmacellularis. | journal = J Am Acad Dermatol | volume = 8 | issue = 3 | pages = 413-6 | month = Mar | year = 1983 | doi = | PMID = 6833541 }}</ref> | *Hemosiderin deposits.<ref name=pmid6833541>{{Cite journal | last1 = Davis | first1 = J. | last2 = Shapiro | first2 = L. | last3 = Baral | first3 = J. | title = Vulvitis circumscripta plasmacellularis. | journal = J Am Acad Dermatol | volume = 8 | issue = 3 | pages = 413-6 | month = Mar | year = 1983 | doi = | PMID = 6833541 }}</ref> | ||
DDx: | DDx: | ||
*[[Syphilis]]. | *[[Syphilis]] - Spirochete immunostain (in red) is helpful. | ||
*Lichenoid drug reaction. | *Spongiotic vulvitis. | ||
**Might look very similar. | |||
**Usually wont show iron deposition. | |||
**Clinical correlation important. | |||
*Superficial fungal vulvitis (usually Candida). | |||
*Lichenoid vulvitis (lichen planus/lichenoid drug reaction). | |||
**Both can be very plasmocellular on mucosal surfaces. | |||
**Zoon vulvitis won't show prominent lichenoid destruction of the epithelium. | |||
====Images==== | ====Images==== | ||
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A CD138 immunostain demonstrates clusters of plasma cells. A p16 immunostain | A CD138 immunostain demonstrates clusters of plasma cells. A p16 immunostain | ||
is negative. Ki-67 positive cells are basal. No microorganisms are apparent | is negative. Ki-67 positive cells are basal. No microorganisms are apparent | ||
with a PASF stain. | with a PASF stain. Perls stain positive iron is admixed with the inflammatory infiltrate. | ||
</pre> | </pre> | ||