653
edits
Difference between revisions of "Papillary thyroid carcinoma"
Jump to navigation
Jump to search
Papillary thyroid carcinoma (view source)
Revision as of 12:17, 30 March 2015
, 12:17, 30 March 2015→Microscopic
| Line 166: | Line 166: | ||
*Circumscribed or even encapsulated neoplasm. | *Circumscribed or even encapsulated neoplasm. | ||
*Morules - interspersed balls of squamoid cells | *Morules - interspersed balls of squamoid cells | ||
** | **No keritinization or intercellular bridges. | ||
**Homogenous, lightly eosinophilic glassy nuclei. | **Homogenous, lightly eosinophilic glassy nuclei (biotin accumulation). | ||
*Follicles | *Follicles | ||
**Cribriform, papillary, trabecular and solid patterns. | **Cribriform, papillary, trabecular and solid patterns. | ||
| Line 187: | Line 187: | ||
IHC: | IHC: | ||
CDX2 - Highlights the morules (CDX2 is positive in the biotin rich nuclei associated with morule formation in a variety of situations)<ref>{{Cite journal | last1 = Wani | first1 = Y. | last2 = Notohara | first2 = K. | last3 = Nakatani | first3 = Y. | last4 = Matsuzaki | first4 = A. | title = Aberrant nuclear Cdx2 expression in morule-forming tumours in different organs, accompanied by cytoplasmic reactivity. | journal = Histopathology | volume = 55 | issue = 4 | pages = 465-8 | month = Oct | year = 2009 | doi = 10.1111/j.1365-2559.2009.03382.x | PMID = 19817898 }}</ref> | CDX2 - Highlights the morules (CDX2 is positive in the biotin rich nuclei associated with morule formation in a variety of situations)<ref>{{Cite journal | last1 = Wani | first1 = Y. | last2 = Notohara | first2 = K. | last3 = Nakatani | first3 = Y. | last4 = Matsuzaki | first4 = A. | title = Aberrant nuclear Cdx2 expression in morule-forming tumours in different organs, accompanied by cytoplasmic reactivity. | journal = Histopathology | volume = 55 | issue = 4 | pages = 465-8 | month = Oct | year = 2009 | doi = 10.1111/j.1365-2559.2009.03382.x | PMID = 19817898 }}</ref> | ||
CD10 - Highlights the morules | |||
Beta-catenin - nuclear and cytoplasmic - all tumour cells. | |||
TTF-1 - positive | |||
DDX: | DDX: | ||