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Difference between revisions of "Paget's disease of the breast"
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Paget's disease of the breast (view source)
Revision as of 15:49, 23 February 2023
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| LMDDx = benign Toker cell hyperplasia, [[malignant melanoma]], [[Bowen's disease]], [[apocrine carcinoma of the skin]] | | LMDDx = benign Toker cell hyperplasia, [[malignant melanoma]], [[Bowen's disease]], [[apocrine carcinoma of the skin]] | ||
| Stains = | | Stains = | ||
| IHC = CK7 +ve, CEA +ve, S-100 -ve, CK5/6 -ve, HER2 +ve | | IHC = CK7 +ve, CEA +ve, S-100 -ve, [[CK5/6]] -ve, HER2 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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Additional: | Additional: | ||
*HER2/neu - usually +ve. | *HER2/neu - usually +ve. | ||
*CK5/6 -ve.<ref>RS. May 2010.</ref> | *[[CK5/6]] -ve.<ref>RS. May 2010.</ref> | ||
**Usu. +ve in squamous cell carcinoma.<ref name=pmid19170169>{{Cite journal | last1 = Khayyata | first1 = S. | last2 = Yun | first2 = S. | last3 = Pasha | first3 = T. | last4 = Jian | first4 = B. | last5 = McGrath | first5 = C. | last6 = Yu | first6 = G. | last7 = Gupta | first7 = P. | last8 = Baloch | first8 = Z. | title = Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. | journal = Diagn Cytopathol | volume = 37 | issue = 3 | pages = 178-83 | month = Mar | year = 2009 | doi = 10.1002/dc.20975 | PMID = 19170169 }}</ref> | **Usu. +ve in squamous cell carcinoma.<ref name=pmid19170169>{{Cite journal | last1 = Khayyata | first1 = S. | last2 = Yun | first2 = S. | last3 = Pasha | first3 = T. | last4 = Jian | first4 = B. | last5 = McGrath | first5 = C. | last6 = Yu | first6 = G. | last7 = Gupta | first7 = P. | last8 = Baloch | first8 = Z. | title = Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. | journal = Diagn Cytopathol | volume = 37 | issue = 3 | pages = 178-83 | month = Mar | year = 2009 | doi = 10.1002/dc.20975 | PMID = 19170169 }}</ref> | ||
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==Sign out== | |||
<pre> | |||
Right Nipple, Biopsy: | |||
- Paget's disease. | |||
Comment: | |||
The Paget-like cells stain as follows: | |||
POSITIVE: CK7 (moderate, diffuse), HER2 (complete membranous, moderate/strong). | |||
NEGATIVE: S-100, HMB-45, CK5, CEA-mono. | |||
The morphologic and immunohistochemical findings are in keeping with Paget's disease of the breast. | |||
The breast imaging findings are noted. | |||
</pre> | |||
==See also== | ==See also== | ||