Granular cell tumour

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The granular cell tumour is a rare beast.

General

  • Rare.
  • Usually benign.
  • May mimic (well-differentiated) squamous cell carcinoma - histopathologically.
    • There is a well-described phenomenon called pseudoepitheliomatous hyperplasia.[1]

Aside:

Gross

  • Yellow nodule.

Note:

  • DDx of yellow nodule: granular cell tumour, lipoma, xanthoma.

Microscopic

Features:

  • Abundant eosinophilic granular cytoplasm.
    • Granules:
      • Size: 1-3 micrometers.
      • Poorly demarcated.

Special stains

  • PAS +ve.

IHC

Features:[2]

  • S100 +ve.
  • CD68 +ve (cytoplasmic).
  • Vimentin +ve (membranous).
  • Calretinin +ve (90-95%).[3]

Images:

See also

References

  1. Abu-Eid R, Landini G (March 2006). "Morphometrical differences between pseudoepitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas". Histopathology 48 (4): 407–16. doi:10.1111/j.1365-2559.2006.02350.x. PMID 16487362.
  2. Rekhi, B.; Jambhekar, NA. (Jun 2010). "Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center.". Ann Diagn Pathol 14 (3): 162-7. doi:10.1016/j.anndiagpath.2010.01.005. PMID 20471560.
  3. Fine, SW.; Li, M. (Feb 2003). "Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors.". Am J Clin Pathol 119 (2): 259-64. doi:10.1309/GRH4-JWX6-J9J7-QQTA. PMID 12579997.