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Difference between revisions of "Embryonal carcinoma"
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| Width = | | Width = | ||
| Caption = Embryonal carcinoma. [[H&E stain]]. | | Caption = Embryonal carcinoma. [[H&E stain]]. | ||
| Micro = vesicular nuclei, nuclear overlap, necrosis (common), mitoses, variable architecture (tubulopapillary, glandular, solid, embryoid bodies) | | Micro = [[vesicular nuclei]], nuclear overlap, necrosis (common), mitoses, variable architecture (tubulopapillary, glandular, solid, embryoid bodies) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[seminoma]], [[mixed germ cell tumour]], [[yolk sac tumour]], other carcinomas | | LMDDx = [[seminoma]], [[mixed germ cell tumour]], [[yolk sac tumour]], other carcinomas | ||
| Line 14: | Line 14: | ||
| Gross = | | Gross = | ||
| Grossing = [[orchiectomy grossing]] | | Grossing = [[orchiectomy grossing]] | ||
| Staging = [[testicular cancer staging]] | |||
| Site = [[testis]], [[ovary]], [[mediastinum]] | | Site = [[testis]], [[ovary]], [[mediastinum]] | ||
| Assdx = | | Assdx = | ||
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Features:<ref name=Ref_GUP549>{{Ref GUP|549}}</ref> | Features:<ref name=Ref_GUP549>{{Ref GUP|549}}</ref> | ||
#Nucleoli - '''key feature'''. | #Nucleoli - '''key feature'''. | ||
#Vesicular nuclei (clear, empty appearing nuclei) - '''key feature'''. | #[[Vesicular nuclei]] (clear, empty appearing nuclei) - '''key feature'''. | ||
#Nuclei overlap. | #Nuclei overlap. | ||
#[[Necrosis]] - common. | #[[Necrosis]] - common. | ||
| Line 91: | Line 92: | ||
===Additional notes=== | ===Additional notes=== | ||
*CK19 -ve.<ref>{{Cite journal | last1 = Bremmer | first1 = F. | last2 = Ströbel | first2 = P. | last3 = Hubertus | first3 = H. | last4 = Strecker | first4 = J. | last5 = Gaisa | first5 = N. | last6 = Strauß | first6 = A. | last7 = Schweyer | first7 = S. | last8 = Radzun | first8 = H-J. | last9 = Behnes | first9 = C-L | title = CK19 is a sensitive marker for yolk sac tumours of the testis. | journal = Diagnostic Pathology | volume = 10 | issue = 7 | pages = | month = | year = 2015 | doi = 10.1186/s13000-015-0243-y | PMID = | url = www.diagnosticpathology.org/content/10/1/7Cached }}</ref> | |||
**[[Yolk sac tumour]] +ve, seminoma -ve, [[GCNIS]] (ITGCN) -ve, normal testis -ve. | |||
*AE1/AE3 +ve. | *AE1/AE3 +ve. | ||
*OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal | last1 = Iczkowski | first1 = KA. | last2 = Butler | first2 = SL. | last3 = Shanks | first3 = JH. | last4 = Hossain | first4 = D. | last5 = Schall | first5 = A. | last6 = Meiers | first6 = I. | last7 = Zhou | first7 = M. | last8 = Torkko | first8 = KC. | last9 = Kim | first9 = SJ. | title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. | journal = Hum Pathol | volume = 39 | issue = 2 | pages = 275-81 | month = Feb | year = 2008 | doi = 10.1016/j.humpath.2007.07.002 | PMID = 18045648 }}</ref> | *OCT3/4 +ve.<ref name=pmid18045648>{{Cite journal | last1 = Iczkowski | first1 = KA. | last2 = Butler | first2 = SL. | last3 = Shanks | first3 = JH. | last4 = Hossain | first4 = D. | last5 = Schall | first5 = A. | last6 = Meiers | first6 = I. | last7 = Zhou | first7 = M. | last8 = Torkko | first8 = KC. | last9 = Kim | first9 = SJ. | title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. | journal = Hum Pathol | volume = 39 | issue = 2 | pages = 275-81 | month = Feb | year = 2008 | doi = 10.1016/j.humpath.2007.07.002 | PMID = 18045648 }}</ref> | ||