Difference between revisions of "Embryonal carcinoma"

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| Gross      =
| Gross      =
| Grossing  =
| Grossing  =
| Site      = [[testis]], [[ovary]]
| Site      = [[testis]], [[ovary]], [[mediastinum]]
| Assdx      =
| Assdx      =
| Syndromes  =
| Syndromes  =
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*Affects young adults.
*Affects young adults.
**May be seen in women.
**May be seen in women.
==Gross==
*Typically a [[testis|testicular mass]].
*May be seen in the [[mediastinum]].<ref name=pmid22877235>PMID 22877235.</ref>


==Microscopic==
==Microscopic==

Revision as of 07:31, 3 July 2013

Embryonal carcinoma
Diagnosis in short

Embryonal carcinoma. H&E stain.

LM vesicular nuclei, nuclear overlap, necrosis (common), mitoses, variable architecture (tubulopapillary, glandular, solid, embryoid bodies)
LM DDx seminoma, mixed germ cell tumour, other carcinomas
IHC CD30 +ve, AE1/AE3 +ve
Site testis, ovary, mediastinum

Signs testicular mass, pelvic mass

Embryonal carcinoma is a type of germ cell tumour. It is commonly as a component of mixed germ cell tumours.

General

  • Affects young adults.
    • May be seen in women.

Gross

Microscopic

Features:[2]

  1. Nucleoli - key feature.
  2. Vesicular nuclei (clear, empty appearing nuclei) - key feature.
  3. Nuclei overlap.
  4. Necrosis - common.
    • Not commonly present in seminoma.
  5. Indistinct cell borders
  6. Mitoses - common.
  7. Variable architecture:
    • Tubulopapillary.
    • Glandular.
    • Solid.
    • Embryoid bodies - ball of cells in surrounded by empty space on three sides.

Notes:

  • Cytoplasmic staining variable (eosinophilic to basophilic).

DDx:

Images

IHC

  • AE1/AE3 +ve.
  • CD30 +ve.

See also

References

  1. PMID 22877235.
  2. Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 549. ISBN 978-0443066771.