Brain metastasis

From Libre Pathology
Revision as of 05:02, 29 October 2014 by Michael (talk | contribs) (split out)
Jump to navigation Jump to search

Brain metastasis, also metastatic brain tumour, is a brain tumour that arose elsewhere and spread to the brain.

General

  • Most common brain tumour in adults.[1][2]
  • Common metastases (in order): lung, breast, kidney, gastrointestinal, melanoma.[3]
  • Percentage of previously diagnosed cancers with brain metastases - by primary site: lung cancer 19.9%, melanoma 6.9%, breast cancer 5.1%, renal cancer 6.5%, colorectal cancer 1.8%.[4]
    • Lung followed by kidney is the order in a smaller series.[5]

Microscopic

Appearance varies by subtype.

Features of metastatic carcinoma:

  • Tubule formation/glands.
  • Usually well-circumscribed/sharply demarcated from surrounding tissue.
  • Usually nuclear atypia including:
    • Nuclear hyperchromasia.
    • Variation of nuclear size.
    • Variation of nuclear shape.
  • Mitoses - common.

DDx:

Images

IHC

  • Carcinoma: pankeratin +ve.
    • Lung adenocarcinoma and SCLC: TTF-1 +ve, CK7 +ve, CK20 -ve.
    • Breast carcinoma: CK7 +ve, ER +ve, PR +ve, BRST2 +ve/-ve.
    • Colorectal carcinoma: CK7 -ve, CK20 +ve, CDX2 +ve, TTF-1 -ve.
    • Clear cell renal cell carcinoma: PAX8 +ve, CK7 -ve, CK20 -ve, vimentin +ve, CD10 +ve.
  • Melanoma: S-100 +ve, HMB-45 +ve, Melan A +ve.

See also

References

  1. Pekmezci, M.; Perry, A. (2013). "Neuropathology of brain metastases.". Surg Neurol Int 4 (Suppl 4): S245-55. doi:10.4103/2152-7806.111302. PMID 23717796.
  2. Suki, D.; Khoury Abdulla, R.; Ding, M.; Khatua, S.; Sawaya, R. (Oct 2014). "Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center.". J Neurosurg Pediatr 14 (4): 372-85. doi:10.3171/2014.7.PEDS13318. PMID 25127097.
  3. Greenwald, J.; Heng, M. (2007). Toronto Notes for Medical Students 2007 (2007 ed.). The Toronto Notes Inc. for Medical Students Inc.. pp. NS9. ISBN 978-0968592878.
  4. Barnholtz-Sloan, JS.; Sloan, AE.; Davis, FG.; Vigneau, FD.; Lai, P.; Sawaya, RE. (Jul 2004). "Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System.". J Clin Oncol 22 (14): 2865-72. doi:10.1200/JCO.2004.12.149. PMID 15254054.
  5. Schouten, LJ.; Rutten, J.; Huveneers, HA.; Twijnstra, A. (May 2002). "Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma.". Cancer 94 (10): 2698-705. PMID 12173339.