Difference between revisions of "Adenocarcinoma of the urinary bladder"

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*CK7 +ve.
*CK7 +ve.
*CK20 +ve.
*CK20 +ve.
*CDX2 +ve (strong, diffuse).
*Beta-catenin +ve (membranous, not nuclear).
**[[Colorectal adenocarcinoma]] usu. has nuclear staining.
*Thrombomodulin +ve/-ve (~60% of cases).
**[[Colorectal adenocarcinoma]] -ve.
**[[Urothelial carcinoma]] +ve (~90% of cases).


==See also==
==See also==

Revision as of 12:16, 15 April 2014

Adenocarcinoma of the urinary bladder, also primary adenocarcinoma of the urinary bladder, is a very uncommon malignant bladder tumour.

General

Clinical:

Microscopic

Features:

  • Nuclear pleomorphism.
  • Glandular differentiation.
  • No urothelial differentiation - important.[2]

DDx:

IHC

Features - variable:[3]

See also

References

  1. 1.0 1.1 Ranadive, NU.; Trivedi, VD.; Gadgil, NM. (Oct 1999). "Primary adenocarcinoma of the urinary bladder: a study of 6 cases from the pathologist's point of view.". Arch Esp Urol 52 (8): 906-11. PMID 11762445.
  2. Zhong, M.; Gersbach, E.; Rohan, SM.; Yang, XJ. (Mar 2013). "Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.". Arch Pathol Lab Med 137 (3): 371-81. doi:10.5858/arpa.2012-0076-RA. PMID 23451748.
  3. Roy, S.; Parwani, AV. (Dec 2011). "Adenocarcinoma of the urinary bladder.". Arch Pathol Lab Med 135 (12): 1601-5. doi:10.5858/arpa.2009-0713-RS. PMID 22129192.