Rheumatoid arthritis

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Rheumatoid arthritis, commonly abbreviated RA, is an autoimmune disorder.

Skin

General

  • May manifest as rheumatoid neutrophilic dermatitis - super rare.[1]

Microscopic

Features:

Joints

Microscopic

Features:

  • Chronic inflammation (e.g. lymphocytes).

Images:

Rheumatoid nodule

General

  • Usually only in seropositive cases.[3]

Microscopic

Features:[3]

  • Necrotic collagen bundles with mucin surrounded by:
  • +/-Eosinophils.

Notes:

Images:

Lung disease

See Medical lung disease.

RA may involve the lung.

Amyloidosis

See Amyloidosis.

Amyloidosis may be due to RA.

Felty syndrome

RA may occur in Felty syndrome -- the triad:[6]

Felty syndrome is assoc. with large granular lymphocytic leukemia.[6]

See also

References

  1. Mashek, HA.; Pham, CT.; Helm, TN.; Klaus, M. (Jun 1997). "Rheumatoid neutrophilic dermatitis.". Arch Dermatol 133 (6): 757-60. PMID 9197831.
  2. URL: http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html. Accessed on: 5 December 2010.
  3. 3.0 3.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 299. ISBN 978-0470519035.
  4. 4.0 4.1 URL: http://granuloma.homestead.com/palisading.html. Accessed on: 1 November 2010.
  5. URL: http://www.pathguy.com/lectures/joints.htm. Accessed on: 1 November 2010.
  6. 6.0 6.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 328. ISBN 978-1416054542.

External links