Panniculitis
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Panniculitis is inflammation of the adipose tissue. It is encountered in dermatopathology specimens.
General DDx
- Erythema nodosum.
- Erythema induratum.
- Self-inflicted trauma.
- Systemic lupus erythematosus.
- Weird stuff.
Specific conditions
Erythema nodosum
- Most common from of panniculitis.[1]
Causes - mnemonic NODOSUM:[1]
- NO cause (idiopathic) ~ 55% of cases.
- Drugs (sulfonamides, amoxicillin, oral contraceptives) ~ 5% of cases.
- Other infections - group A streptococci (streptococcal pharyngitis), Yersinia, chlamydia, mycobacteria, others ~ 30% of cases.
- Sarcoidosis ~ 7% of cases.
- Ulcerative colitis & Crohn's disease ~ 2% of cases.
- Malignancy (leukemia, Hodgkin's lymphoma) ~ 1% of cases
Microscopic
Features:[2]
- Expanded (inter-adipocyte cluster) septa.
- Neutrophils.
- Fibrin.
Notes:
- No vasculitis.
Erythema induratum
General
Features:[2]
- Not common.
- Etiology: unknown.
Microscopic
Features:[2]
- Necrotizing granulomatous inflammation.
- Necrotizing vasculitis of small/medium sized vessels (early).
DDx:
- Infection.
See also
References
- ↑ 1.0 1.1 Schwartz, RA.; Nervi, SJ. (Mar 2007). "Erythema nodosum: a sign of systemic disease.". Am Fam Physician 75 (5): 695-700. PMID 17375516.
- ↑ 2.0 2.1 2.2 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1199. ISBN 978-1416031215.