Difference between revisions of "NUT carcinoma"
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==Molecular== | ==Molecular== | ||
*Rearrangement of the ''NUT'' gene.<ref name=pmid20951314/> | *Rearrangement of the ''NUT'' gene.<ref name=pmid20951314/> | ||
**Most common: t(15;19)( | **Most common: t(15;19)(q13;p13.1) ''BRD4/NUT''.<ref>{{OMIM|608749}}</ref> | ||
***One source suggests it is: ''t(15;19)(q14;p13.1)''.<ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 01:41, 17 November 2011
NUT midline carcinoma is a super rare tumour.
General
- Not specific to any tissue type or organ.[1]
- Defined by mutation in NUT gene.
- NUT = Nuclear protein in testis.[2]
Clinical:
- Usually midline - as the name of the tumour suggests.
- Head, neck and mediastinum.[3]
- Poor prognosis.
Microscopic
- Poorly differentiated carcinoma.
- Cohesive malignant cells.
- Islands of well-differentiated squamous epithelium - key feature.
DDx:
- Carcinoma ex pleomorphic adenoma.
- Poorly differentiated carcinoma.
Molecular
- Rearrangement of the NUT gene.[1]
See also
References
- ↑ 1.0 1.1 1.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ 3.0 3.1 3.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749