Difference between revisions of "Leiomyosarcoma"
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*Poor prognosis. | *Poor prognosis. | ||
*Do not (generally) arise from leiomyomas. | *Do not (generally) arise from leiomyomas. | ||
*Often singular, i.e. one tumour; unlike | *Often singular, i.e. one tumour; unlike [[leiomyoma]]s (which are often multiple). | ||
==Gross== | ==Gross== | ||
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*[[Soft tissue lesions]]. | *[[Soft tissue lesions]]. | ||
*[[Uterine tumours]]. | *[[Uterine tumours]]. | ||
*[[Leiomyoma]]. | |||
==References== | ==References== | ||
Revision as of 04:47, 3 June 2011
Leiomyosarcoma is a malignant tumour of smooth muscle. It is seen in various places including the uterus and skin.
General
- Poor prognosis.
- Do not (generally) arise from leiomyomas.
- Often singular, i.e. one tumour; unlike leiomyomas (which are often multiple).
Gross
Features:
- "Fleshy" appearance.
- Necrosis.
- Large size.
- Often singular, i.e. one lesion; leiomyomata are often multiple.
Microscopic
Features:
- Cellular lesion.
- Fasicular arrangement:
- Whorled look at low power.
- Groups of spindle cells cut peripendicular to their long axis adjacent to groups of spindle cells cut in the plane of their long axis.
- Features of malignancy (need all three):
IHC
- CD10 -ve (important in the context of uterine lesions -- +ve in endometrial stromal sarcoma).
- Positive for SMC markers.
- Desmin - present in all three types of muscle.
- Caldesmon.
- Smooth muscle myosin.
See also
References
- ↑ Kraft S, Fletcher CD (April 2011). "Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma"". Am. J. Surg. Pathol. 35 (4): 599–607. doi:10.1097/PAS.0b013e31820e6093. PMID 21358302.