48,470
edits
Difference between revisions of "Nodular hyperplasia of the prostate gland"
Jump to navigation
Jump to search
Nodular hyperplasia of the prostate gland (view source)
Revision as of 20:42, 24 April 2024
, 24 Aprilcreate
(create) |
|||
| (12 intermediate revisions by the same user not shown) | |||
| Line 7: | Line 7: | ||
| Micro = stromal and/or glandular hyperplasia | | Micro = stromal and/or glandular hyperplasia | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[smooth muscle tumour of uncertain malignant potential]], subtle [[prostate carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 18: | Line 18: | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = old man | ||
| Signs = hematuria, weak urine stream, incomplete urinary emptying, post-void dribbling, prolonged voiding, intermittency, hesitancy | | Signs = hematuria, weak urine stream, incomplete urinary emptying, post-void dribbling, prolonged voiding, intermittency, hesitancy | ||
| Symptoms = increased frequency of urination, straining | | Symptoms = increased frequency of urination, straining | ||
| Line 28: | Line 28: | ||
| Other = | | Other = | ||
| ClinDDx = other causes of hematuria ([[urothelial carcinoma]], [[renal cell carcinoma]], cystitis), other causes of obstruction ([[prostate carcinoma]], [[urothelial carcinoma]]) | | ClinDDx = other causes of hematuria ([[urothelial carcinoma]], [[renal cell carcinoma]], cystitis), other causes of obstruction ([[prostate carcinoma]], [[urothelial carcinoma]]) | ||
| Tx = medical, TURP | | Tx = medical, [[TURP]], others | ||
}} | }} | ||
'''Nodular hyperplasia of the prostate gland''', also '''benign prostatic hyperplasia''' (abbreviated '''BPH'''), is a common benign pathology of the [[prostate gland]]. | '''Nodular hyperplasia of the prostate gland''', also '''benign prostatic hyperplasia''' (abbreviated '''BPH'''), is a common benign pathology of the [[prostate gland]]. | ||
| Line 54: | Line 54: | ||
*Medications. | *Medications. | ||
*Transurethral resection of the prostate (TURP). | *Transurethral resection of the prostate (TURP). | ||
*[[Rezum]].<ref>{{cite journal |authors=Westwood J, Geraghty R, Jones P, Rai BP, Somani BK |title=Rezum: a new transurethral water vapour therapy for benign prostatic hyperplasia |journal=Ther Adv Urol |volume=10 |issue=11 |pages=327–333 |date=November 2018 |pmid=30344644 |pmc=6180381 |doi=10.1177/1756287218793084 |url=}}</ref> | |||
*Laser treatment ([[GreenLight]]).<ref name=pmid31617419>{{cite journal |authors=Campobasso D, Marchioni M, Altieri V, Greco F, De Nunzio C, Destefanis P, Ricciardulli S, Bergamaschi F, Fasolis G, Varvello F, Voce S, Palmieri F, Divan C, Malossini G, Oriti R, Tuccio A, Ruggera L, Tubaro A, Delicato G, Laganà A, Dadone C, De Rienzo G, Frattini A, Pucci L, Carrino M, Montefiore F, Germani S, Miano R, Schips L, Rabito S, Ferrari G, Cindolo L |title=GreenLight Photoselective Vaporization of the Prostate: One Laser for Different Prostate Sizes |journal=J Endourol |volume=34 |issue=1 |pages=54–62 |date=January 2020 |pmid=31617419 |doi=10.1089/end.2019.0478 |url=}}</ref> | |||
==Gross== | ==Gross== | ||
| Line 62: | Line 64: | ||
Features: | Features: | ||
*Stromal and/or glandular hyperplasia. | *Stromal and/or glandular hyperplasia. | ||
**Stromal component has small blood vessels. | |||
Notes: | |||
*Should '''not''' be diagnosed on core biopsy! | *Should '''not''' be diagnosed on core biopsy! | ||
*One series suggests clinically relevant prostate cancer is seen in ~1.5% of resections for BPH.<ref>{{Cite journal | last1 = Skrzypczyk | first1 = MA. | last2 = Dobruch | first2 = J. | last3 = Nyk | first3 = L. | last4 = Szostek | first4 = P. | last5 = Szempliński | first5 = S. | last6 = Borówka | first6 = A. | title = Should all specimens taken during surgical treatment of patients with benign prostatic hyperplasia be assessed by a pathologist? | journal = Cent European J Urol | volume = 67 | issue = 3 | pages = 227-32 | month = | year = 2014 | doi = 10.5173/ceju.2014.03.art2 | PMID = 25247076 }}</ref> | |||
DDx: | DDx: | ||
*[[Urothelial carcinoma]] - significant nuclear atypia. | *[[Urothelial carcinoma]] - significant nuclear atypia. | ||
*[[Prostate carcinoma]] - especially low-grade. | *[[Prostate carcinoma]] - especially low-grade. | ||
*[[Prostatic stromal tumour of uncertain malignant potential]] - lacks small vessels.<ref name=pmid17170745>{{Cite journal | last1 = Hansel | first1 = DE. | last2 = Herawi | first2 = M. | last3 = Montgomery | first3 = E. | last4 = Epstein | first4 = JI. | title = Spindle cell lesions of the adult prostate. | journal = Mod Pathol | volume = 20 | issue = 1 | pages = 148-58 | month = Jan | year = 2007 | doi = 10.1038/modpathol.3800676 | PMID = 17170745 }}</ref> | |||
===Images=== | ===Images=== | ||
| Line 77: | Line 82: | ||
==Sign out== | ==Sign out== | ||
===Urothelium present=== | ===Urothelium present=== | ||
<pre> | |||
Prostate Tissue, Transurethral Resection of Prostate (TURP): | |||
- Benign prostatic tissue with glandular and stromal proliferation. | |||
- Benign urothelial mucosa with inflammation. | |||
- NEGATIVE for malignancy. | |||
</pre> | |||
<pre> | |||
Prostate Tissue, Transurethral Resection of Prostate (TURP): | |||
- Benign prostatic tissue. | |||
- Benign urothelial mucosa with mild inflammation and calcification. | |||
- NEGATIVE for malignancy. | |||
</pre> | |||
====Block letters==== | |||
<pre> | <pre> | ||
PROSTATE TISSUE, TRANSURETHRAL RESECTION OF THE PROSTATE (TURP): | PROSTATE TISSUE, TRANSURETHRAL RESECTION OF THE PROSTATE (TURP): | ||