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Difference between revisions of "Hibernoma"
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'''Hibernoma''' | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Hibernoma1.jpg | |||
| Width = | |||
| Caption = Hibernoma. [[H&E stain]]. | |||
| Micro = large polygonal/oval cells with central & small nucleus; nucleoli typically prominent; cytoplasm multivacuolated, oval, eosinophilic, granular | |||
| Subtypes = | |||
| LMDDx = reaction to silicone implant | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = lobulated lesion, light-brown, usually extremities | |||
| Grossing = | |||
| Site = cervical-supraclavicular, periaortic - both thorax and the abdomen, perirenal; see ''[[soft tissue lesions|soft tissue]]'' - [[adipocytic lesions]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = typically young adults | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = [[Lipoma]] | |||
}} | |||
'''Hibernoma''', also '''tumour of [[brown fat]]''',<ref>{{Cite journal | last1 = SHUTE | first1 = D. | title = Tumours of brown fat. | journal = Can Med Assoc J | volume = 71 | issue = 5 | pages = 484-5 | month = Nov | year = 1954 | doi = | PMID = 13209434 }}</ref> is an uncommon [[adipocytic tumour]]. | |||
==General== | ==General== | ||
| Line 7: | Line 36: | ||
Epidemiology: | Epidemiology: | ||
*Young adults. | *Young adults - disappears with age.<ref name=pmid31281288>{{cite journal |authors=Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, Rossi A, Zamboni M |title=Brown and Beige Adipose Tissue and Aging |journal=Front Endocrinol (Lausanne) |volume=10 |issue= |pages=368 |date=2019 |pmid=31281288 |pmc=6595248 |doi=10.3389/fendo.2019.00368 |url=}}</ref> | ||
==Gross== | ==Gross== | ||
*Well-circumscribed. | *Well-circumscribed. | ||
*Lobulated and light-brown on sectioning. | *Lobulated and light-brown on sectioning. | ||
Locations:<ref name=pmid31281288/> | |||
*Cervical-supraclavicular. | |||
*Periaortic - both thorax and the abdomen. | |||
*Perirenal. | |||
==Microscopic== | ==Microscopic== | ||
| Line 24: | Line 58: | ||
*Reaction to silicone implant. | *Reaction to silicone implant. | ||
=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Hibernoma1.jpg | Hibernoma - high mag. (WC) | Image:Hibernoma1.jpg | Hibernoma - high mag. (WC) | ||
Image: | Image:Hibernoma2.jpg | Hibernoma - intermed mag. (WC) | ||
Image:Hibernoma3.jpg | Hibernoma - low mag. (WC) | Image:Hibernoma3.jpg | Hibernoma - low mag. (WC) | ||
</gallery> | </gallery> | ||
| Line 34: | Line 68: | ||
*[[Adipocytic tumours]]. | *[[Adipocytic tumours]]. | ||
*[[Lipoma]]. | *[[Lipoma]]. | ||
*[[Brown tumour]]. | |||
==References== | ==References== | ||