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Difference between revisions of "Squamous cell carcinoma of the head and neck"
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Squamous cell carcinoma of the head and neck (view source)
Revision as of 18:09, 5 March 2024
, 5 Marchno edit summary
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| Micro = | | Micro = | ||
| Subtypes = keratinizing type, undifferentiated type, nonkeratinizing type | | Subtypes = keratinizing type, undifferentiated type, nonkeratinizing type | ||
| LMDDx = [[squamous dysplasia of the head and neck]], [[HPV-associated head and neck squamous cell carcinoma]], [[nasopharyngeal carcinoma]], [[malignant melanoma]], metastatic [[squamous cell carcinoma]] | | LMDDx = [[squamous dysplasia of the head and neck]], [[HPV-associated head and neck squamous cell carcinoma]], [[nasopharyngeal carcinoma]], [[malignant melanoma]], metastatic [[squamous cell carcinoma]] (esp. [[skin SCC]] of lateral head), [[NUT carcinoma]], [[pseudoepitheliomatous hyperplasia]] | ||
| Stains = | | Stains = | ||
| IHC = p63 +ve, CK5/6, p16 -ve, EBER -ve | | IHC = p63 +ve, CK5/6, p16 -ve, EBER -ve | ||
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==Microscopic== | ==Microscopic== | ||
Features based on classification:<ref name=Ref_Sternberg4_975>{{Ref Sternberg4|975}}</ref> | Features based on classification:<ref name=Ref_Sternberg4_975>{{Ref Sternberg4|975}}</ref> | ||
*KT subtype: | *Keratinizing type (KT) subtype: | ||
**Keratinization & intercellular bridges through-out most of the malignant lesion. | **Keratinization & intercellular bridges through-out most of the malignant lesion. | ||
*UT: | *Undifferentiated type (UT): | ||
**Non-distinct borders/syncytial pattern. | **Non-distinct borders/syncytial pattern. | ||
**Nucleoli. | **Nucleoli. | ||
*NT: | *Nonkeratinizing (NT): | ||
**Well-defined cell borders. | **Well-defined cell borders. | ||
DDx: | |||
*[[SMARCB1-deficient sinonasal carcinoma]]. | |||
*[[Sinonasal undifferentiated carcinoma]]. | |||
*[[Human papillomavirus-related multiphenotypic sinonasal carcinoma]] - previously known as ''HPV-related carcinoma with adenoid cystic-like features''. | |||
*[[NUT carcinoma]] - has well-differentiated squamous "islands" that are sharply demarcated from poorly differentiated surrounding tumour. | |||
*[[Neuroendocrine tumour]]. | |||
*Metastatic [[skin SCC|squamous cell carcinoma of skin]] - esp. parotid lesions, history of skin SCC (esp. lateral aspect of head).<ref name=pmid16783833>{{cite journal |authors=Vauterin TJ, Veness MJ, Morgan GJ, Poulsen MG, O'Brien CJ |title=Patterns of lymph node spread of cutaneous squamous cell carcinoma of the head and neck |journal=Head Neck |volume=28 |issue=9 |pages=785–91 |date=September 2006 |pmid=16783833 |doi=10.1002/hed.20417 |url=}}</ref> | |||
*[[Pseudoepitheliomatous hyperplasia]]. | |||
====Invasion==== | ====Invasion==== | ||
| Line 126: | Line 135: | ||
*Need keratinization. (???) | *Need keratinization. (???) | ||
====Lymphoepithelial (squamous cell) carcinoma==== | ====Lymphoepithelial (squamous cell) carcinoma==== | ||
| Line 135: | Line 140: | ||
==IHC== | ==IHC== | ||
*[[p63]] +ve. | |||
*[[ | *[[p16]] -ve. | ||
* | |||
**Positive suggests [[HPV-associated head and neck squamous cell carcinoma]]. | **Positive suggests [[HPV-associated head and neck squamous cell carcinoma]]. | ||
*Bcl2 +ve/-ve. | *Bcl2 +ve/-ve. | ||
**Positive = poor prognosis.<ref name=pmid20233885>{{cite journal |author=Nichols AC, Finkelstein DM, Faquin WC, ''et al.'' |title=Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer |journal=Clin. Cancer Res. |volume=16 |issue=7 |pages=2138–46 |year=2010 |month=April |pmid=20233885 |doi=10.1158/1078-0432.CCR-09-3185 |url=}}</ref> | **Positive = poor prognosis.<ref name=pmid20233885>{{cite journal |author=Nichols AC, Finkelstein DM, Faquin WC, ''et al.'' |title=Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer |journal=Clin. Cancer Res. |volume=16 |issue=7 |pages=2138–46 |year=2010 |month=April |pmid=20233885 |doi=10.1158/1078-0432.CCR-09-3185 |url=}}</ref> | ||
==Molecular== | |||
*[[EBER]] -ve. | |||
**Positive suggests [[nasopharyngeal carcinoma]]. | |||
==Sign out== | ==Sign out== | ||