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Difference between revisions of "Irritable bowel syndrome"
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'''Irritable bowel syndrome''', abbreviated '''IBS''', is a diagnosis exclusion that | '''Irritable bowel syndrome''', abbreviated '''IBS''', is a diagnosis exclusion that is considered to have no histopathologic abnormalities on routine histologic examination.<ref name=pmid17013373>{{cite journal |author=Kirsch R, Kirsch RH, Riddell RH, Riddell R |title=Histopathological alterations in irritable bowel syndrome |journal=Mod. Pathol. |volume=19 |issue=12 |pages=1638–45 |year=2006 |month=December |pmid=17013373 |doi=10.1038/modpathol.3800704 |url=http://www.nature.com/modpathol/journal/v19/n12/full/3800704a.html}}</ref> | ||
==General== | |||
*[[Clinical diagnosis]] - different criteria exist ''Manning'' and ''Rome''.<ref name=pmid1415096>{{Cite journal | last1 = MacIntosh | first1 = DG. | last2 = Thompson | first2 = WG. | last3 = Patel | first3 = DG. | last4 = Barr | first4 = R. | last5 = Guindi | first5 = M. | title = Is rectal biopsy necessary in irritable bowel syndrome? | journal = Am J Gastroenterol | volume = 87 | issue = 10 | pages = 1407-9 | month = Oct | year = 1992 | doi = | PMID = 1415096 }}</ref> | |||
*[[Fecal calprotectin]] negative.<ref name=pmid30407259>{{Cite journal | last1 = Nemakayala | first1 = DR. | last2 = Cash | first2 = BD. | title = Excluding irritable bowel syndrome in the inflammatory bowel disease patient: how far to go? | journal = Curr Opin Gastroenterol | volume = 35 | issue = 1 | pages = 58-62 | month = Jan | year = 2019 | doi = 10.1097/MOG.0000000000000493 | PMID = 30407259 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*No abnormalities - see ''[[normal colon]]''. | |||
DDx - subtle pathologies: | |||
*[[Lymphocytic colitis]]. | |||
*[[Cryptosporidiosis]]. | |||
*[[Intestinal spirochetes]].<ref>{{cite journal |authors=Walker MM, Talley NJ, Inganäs L, Engstrand L, Jones MP, Nyhlin H, Agréus L, Kjellstrom L, Öst Å, Andreasson A |title=Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden |journal=Hum Pathol |volume=46 |issue=2 |pages=277–83 |date=February 2015 |pmid=25540866 |doi=10.1016/j.humpath.2014.10.026 |url=}}</ref> . | |||
Note: | |||
*No significant association with other endoscopically subtle pathology, e.g. [[melanosis coli]] and [[microscopic colitis]], when clinical criteria are fulfilled.<ref name=pmid1415096/> | |||
==See also== | |||
*[[Colon]]. | |||
*[[Inflammatory bowel disease]]. | |||
==References== | ==References== | ||