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Difference between revisions of "Esophageal adenocarcinoma"
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| LMDDx = [[high-grade columnar dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]],[[gastric adenocarcinoma]] | | LMDDx = [[high-grade columnar dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]],[[gastric adenocarcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CK7 +ve, CK20 | | IHC = CK7 +ve, CK20 -ve, p63 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 15: | Line 15: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[esophagus]] | | Site = [[esophagus]] - classically distal esophagus | ||
| Assdx = [[Barrett's esophagus]], [[high-grade columnar dysplasia of the esophagus]] | | Assdx = [[Barrett's esophagus]], [[high-grade columnar dysplasia of the esophagus]] | ||
| Syndromes = | | Syndromes = | ||
| Line 91: | Line 91: | ||
*M3 = submucosa. | *M3 = submucosa. | ||
*M4 = muscularis propria. | *M4 = muscularis propria. | ||
<!-- | |||
Comment: | Comment: | ||
*Different staging systems exist | *Different staging systems exist; confusingly, they use the same terms (M1, M2, M3).<ref name=pmid15557945>{{Cite journal | last1 = Buskens | first1 = CJ. | last2 = Westerterp | first2 = M. | last3 = Lagarde | first3 = SM. | last4 = Bergman | first4 = JJ. | last5 = ten Kate | first5 = FJ. | last6 = van Lanschot | first6 = JJ. | title = Prediction of appropriateness of local endoscopic treatment for high-grade dysplasia and early adenocarcinoma by EUS and histopathologic features. | journal = Gastrointest Endosc | volume = 60 | issue = 5 | pages = 703-10 | month = Nov | year = 2004 | doi = | PMID = 15557945 }}</ref> --> | ||
==IHC== | ==IHC== | ||
*CK7 +ve. | Features:<ref name=pmid14631371>{{cite journal |authors=Driessen A, Nafteux P, Lerut T, Van Raemdonck D, De Leyn P, Filez L, Penninckx F, Geboes K, Ectors N |title=Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications |journal=Mod Pathol |volume=17 |issue=1 |pages=49–55 |date=January 2004 |pmid=14631371 |doi=10.1038/modpathol.3800011 |url=}}</ref> | ||
*CK20 +ve. | *CK7 +ve (54 of 66 cases). | ||
*CK20 -ve (14 of 66 cases). | |||
Note: | |||
*CK7 +ve and CK20 -ve is seen in ~67% cases (44/66).<ref name=pmid14631371/> | |||
To rule-out SCC: | To rule-out SCC: | ||